scholarly journals Genetic Resistance to Prion Diseases

10.5772/66916 ◽  
2017 ◽  
Author(s):  
Yalçin Yaman ◽  
Cemal Ün
Keyword(s):  
Prion Diseases ◽  
Genetic Resistance

scholarly journals Genetic variation in disease resistance among farm animals

2009 ◽  
Vol 25 (5-6-1) ◽  
pp. 339-347 ◽  
Author(s):  
S. Jovanovic ◽  
M. Savic ◽  
D. Zivkovic
Keyword(s):  
Genetic Variation ◽  
Prion Diseases ◽  
Genetic Resistance ◽  
Local Environment ◽  
Pathogen Resistance ◽  
Vital Role ◽  
Farm Animals ◽  
Control Mechanisms ◽  
High Level ◽  
Selection Of

This background study paper reviews the results of scientific investigations involving genetic control mechanisms for resistance/tolerance in farm animals to specific viral, bacterial, parasitic and prion diseases. The paper presents the most prominent documented examples for resistance/tolerance in cows, sheep and goats, pigs and poultry. The importance of genetically heterogeneous populations is highlighted, particularly as they impact response to epidemics, their duration, lower mortality rates, etc. Genetic studies on resistance in farm animals to a variety of etiological infectious agents can be determined at three genetic levels of variation: species, breed and unique genetic variation among individual animals. Depending upon the etiology of disease and the available animal resources, strategies for developing genetic disease management can be developed at the following levels: selection of breeds that are particularly well adapted to the local environment, breeding methods which include the introduction of genes exhibiting genetic resistance/tolerance towards pathogenic organisms, and the selection of individual animals with a high level of specific pathogen resistance. The most recent epidemic zoonoses illustrate how important it has become to develop global mechanisms for control of zoonoses and consequently the vital role of veterinary services in disease control.

Rapid Quantification of Prion Proteins

2019 ◽  
Author(s):  
Matthew Healey ◽  
Muttuswamy Sivakumaran ◽  
Mark Platt
Keyword(s):  
Prion Proteins ◽  
Prion Diseases ◽  
Sample Volume ◽  
Cellular Prion Protein ◽  
Dna Aptamer ◽  
Superparamagnetic Beads ◽  
Resistive Pulse ◽  
Large Sample Volume ◽  
Complex Sample ◽  
Neurological Conditions

<p>Prion diseases are a group of fatal transmissible neurological conditions caused by the change in conformation of the normal intrinsic cellular prion protein (PrP<sup>C</sup>) in to the highly ordered insoluble amyloid state conformer (PrP<sup>SC</sup>). We present a rapid assay using Aptamers and Resistive Pulse Sensing, RPS, to extract and quantify proteins from complex sample matrices, demonstrate with the quantification of PrP<sup>c</sup>. We functionalise the surface of superparamagnetic beads, SPBs, with a DNA aptamer. First SPB’s termed P-Beads, are used to pre-concentrate the analyte from a large sample volume. The PrP<sup>c</sup> protein is then eluted from the P-Beads before aptamer modified sensing beads, S-Beads, are added. The velocity of the S-Beads through the nanopore reveals the concentration of the PrP<sup>c</sup> protein. The process is done in under an hour and allows the detection of picomol’s of protein. The technique could be easily adopted to the mutated version of the protein and integrated into clinical workflows for the screening of blood donations and transfusions. </p>

Genetic Resistance to Boll Weevil Oviposition in Primitive Cotton 1

Crop Science ◽  
1987 ◽  
Vol 27 (2) ◽  
pp. 263-264 ◽  
Author(s):  
J. C. McCarty ◽  
J. N. Jenkins ◽  
W. L. Parrott
Keyword(s):  
Genetic Resistance ◽  
Boll Weevil
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