scholarly journals Genetic variation in disease resistance among farm animals

2009 ◽  
Vol 25 (5-6-1) ◽  
pp. 339-347 ◽  
Author(s):  
S. Jovanovic ◽  
M. Savic ◽  
D. Zivkovic
Keyword(s):  
Genetic Variation ◽  
Prion Diseases ◽  
Genetic Resistance ◽  
Local Environment ◽  
Pathogen Resistance ◽  
Vital Role ◽  
Farm Animals ◽  
Control Mechanisms ◽  
High Level ◽  
Selection Of

This background study paper reviews the results of scientific investigations involving genetic control mechanisms for resistance/tolerance in farm animals to specific viral, bacterial, parasitic and prion diseases. The paper presents the most prominent documented examples for resistance/tolerance in cows, sheep and goats, pigs and poultry. The importance of genetically heterogeneous populations is highlighted, particularly as they impact response to epidemics, their duration, lower mortality rates, etc. Genetic studies on resistance in farm animals to a variety of etiological infectious agents can be determined at three genetic levels of variation: species, breed and unique genetic variation among individual animals. Depending upon the etiology of disease and the available animal resources, strategies for developing genetic disease management can be developed at the following levels: selection of breeds that are particularly well adapted to the local environment, breeding methods which include the introduction of genes exhibiting genetic resistance/tolerance towards pathogenic organisms, and the selection of individual animals with a high level of specific pathogen resistance. The most recent epidemic zoonoses illustrate how important it has become to develop global mechanisms for control of zoonoses and consequently the vital role of veterinary services in disease control.

Energy Efficiency Analysis in ERA using NFL-BA Algorithm

2020 ◽  
pp. 340-348
Author(s):  
Palky Mehta ◽  
H. L. Sharma
Keyword(s):  
Cluster Head ◽  
Vital Role ◽  
Wireless Sensor ◽  
Energy Usage ◽  
Cluster Heads ◽  
Comparison Results ◽  
Current Scenario ◽  
Energy Efficiency Analysis ◽  
Selection Of

In the current scenario of Wireless Sensor Network (WSN), power consumption is the major issue associated with nodes in WSN. LEACH technique plays a vital role of clustering in WSN and reduces the energy usage effectively. But LEACH has its own limitation in order to search cluster head nodes which are randomly distributed over the network. In this paper, ERA-NFL- BA algorithm is being proposed for selects the cluster heads in WSN. This algorithm help in selection of cluster heads can freely transform from global search to local search. At the end, a comparison has been done with earlier researcher using protocol ERA-NFL, which clearly shown that proposed Algorithm is best suited and from comparison results that ERA-NFL-BA has given better performance.

CONNECTION g.307 G > A SNP POLYMORPHISM OF THE ALPHA-FUKOZYLTRASFERAZA 1 GENE WITH ECONOMIC-USEFUL TRAITS IN THE LARGE WHITE PIG BREED

2017 ◽  
Vol 54 ◽  
pp. 134-140
Author(s):  
H. S. Rudoman ◽  
V. M. Balatsky ◽  
V. Y. Nor ◽  
V. O. Vovk
Keyword(s):  
Genetic Structure ◽  
Information Content ◽  
Analysis Of Variance ◽  
Farm Animals ◽  
Daily Weight Gain ◽  
Fixation Index ◽  
Its Sequencing ◽  
Large White ◽  
Stage Of Development ◽  
High Level

One of the top priorities at the present stage of development of pig breeding remains the development of a set of measures aimed at increasing the resistance animals to various diseases, especially – to colibacteriosis .One of the recent and effective approaches to prevent colibacillosis is using markers of selection; it involves pig genotyping by genome locuses. Chosen locuses are associated with animal sensitivity to the disease and selection of the results of genotyping of animals with increased resistance. Due to researches, one of such locuses is alpha-fukozyltrasferаza 1 gene (FUT1). Gene FUT1 is located in chromosome 6. As a result of its sequencing in the swine breeds of Large White and Swedish Landrace, single-nucleotide polymorphism (g.307 G > A SNP) has been detected. AA genotype determines the resistance of animals to colibacteriosis, while AG and GG genotypes are susceptible to this disease. According to the results of previous studies, the positive effect of allele A was determined not only on the resistance of pigs to colibacteriosis, but also on indicators of fattening and meat productivity and on reproductive performance. In Ukraine, the studies of polymorphism FUT1 g.307 G > A SNP were held fragmentedly and only on certain populations of Ukrainian Meat and Large White breed but without establishing its association with the indicators of productivity of pigs. The aim of our work was to study the genetic structure of Ukrainian Large White breeds, type 1 and the establishment of association. g. 307 G > A SNP FUT1 gene with pigs indicators of productivity. For research the 96 samples of hair were used. DNA isolation from samples with biomaterial were carried out using ion exchange resin Chelex-100. Genotyping was performed by PCR-RFLP by method of Jorgensen et al. (2006). Using DNA analysis of this breeds locus FUT1 was determined by genetic structure. Allele frequency of allele G (0,573) and allele A (0,427) was established The distribution of genotype frequencies was not statistically significantly different from the theoretically expected, calculated by the Hardy-Weinberg criterion. Thus, according to the locus of FUT1 g.307 G > A, the breeds investigated are in a state close to the genetic equilibrium. The negative value of the fixation index by the locus FUT1 g.307 G > A indicates an excess of heterozygotes in the population, and hence the lack of targeted selection for this marker. The valuation was performed by calculating the PIC (polymorphic information content) – information content of polymorphism marker. In the analyzed pig herd for this marker, the PIC has an average value (0,367), which indicates the high level of polymorphism of the given locus and is favorable for the possibility of conducting a search for links between individual genotypes and indicators of productivity. To establish the association g.307 G > A SNP FUT1 gene with indicators of animal productivity, a one-way analysis of variance of the experimental data was used. Based on the results of a one-way analysis of variance, a significant effect of the genotypes of the FUT1gene (g.1849 G > C) on the indicator of the average daily weight gain (р ≤ 0,001), the thickness of the bacon at the level of the VI-VII vertebrae (p ≤ 0.01), reaching live weight of 100 kg (р ≤ 0,001) and breeding index of fattening qualities (р ≤ 0,01) was found. The parameter of the influence of the genetic factor on the test feature was 28,54%, 10,4%, 33,4% and 8,8% respectively. According to the investigated indicators of productivity, animals with genotype AA, which determines resistance to colibacteriosis, dominated the animals with genotypes GG and AG. Based on the results of our research and pre-published data, the multiple effect of the g.307 G > A SNP FUT1 gene is observed, which is associated with the indicators of productivity, which again confirms the polygenicity of the quantitative trait loci of farm animals. Taking into account a high level of polymorphism of the investigated gene and reliable associations of genotypes with indicators of productivity found, it can be recommended to carry out breeding of pigs using genetic information of the g.307 G > A SNP gene FUT1.

SBA MCQs for the MRCS Part A

2012 ◽  
Author(s):  
Sri G. Thrumurthy ◽  
Tania Samantha De Silva ◽  
Zia Moinuddin ◽  
Stuart Enoch
Keyword(s):  
Clinical Case ◽  
Multiple Choice ◽  
Surgical Anatomy ◽  
Surgical Patients ◽  
Multiple Choice Questions ◽  
Basic Sciences ◽  
Self Assessment ◽  
High Level ◽  
Factual Recall ◽  
Selection Of

Specifically designed to help candidates revise for the MRCS exam, this book features 350 Single Best Answer multiple choice questions, covering the whole syllabus. Containing everything candidates need to pass the MRCS Part A SBA section of the exam, it focuses intensively on the application of basic sciences (applied surgical anatomy, physiology, and pathology) to the management of surgical patients. The high level of detail included within the questions and their explanations allows effective self-assessment of knowledge and quick identification of key areas requiring further attention. Varying approaches to Single Best Answer multiple choice questions are used, giving effective exam practice and guidance through revision and exam technique. This includes clinical case questions, 'positively-worded' questions, requiring selection of the most appropriate of relatively correct answers; 'two-step' or 'double-jump' questions, requiring several cognitive steps to arrive at the correct answer; as well as 'factual recall' questions, prompting basic recall of facts.

scholarly journals POPULATION GENETICS OF ALLOZYME VARIATION IN NEUROSPORA INTERMEDIA

Genetics ◽  
1975 ◽  
Vol 80 (4) ◽  
pp. 785-805
Author(s):  
P T Spieth
Keyword(s):  
Genetic Variation ◽  
Vegetative Reproduction ◽  
Vascular Plant ◽  
Natural Populations ◽  
Allozyme Variation ◽  
Regular Feature ◽  
Local Populations ◽  
Neurospora Intermedia ◽  
Pattern Of Variation ◽  
High Level

ABSTRACT Electrophoretically detectable variation in the fungus Neurospora intermedia has been surveyed among isolates from natural populations in Malaya, Papua, Australia and Florida. The principal result is a pattern of genetic variation within and between populations that is qualitatively no different than the well documented patterns for Drosophila and humans. In particular, there is a high level of genetic variation, the majority of which occurs at the level of local populations. Evidence is presented which argues that N. intermedia has a population structure analogous to that of an annual vascular plant with a high level of vegetative reproduction. Sexual reproduction appears to be a regular feature in the biology of the species. Substantial heterokaryon function seems unlikely in natural populations of N. intermedia. Theoretical considerations concerning the mechanisms underlying the observed pattern of variation most likely should be consistent with haploid selection theory. The implications of this constraint upon the theory are discussed in detail, leading to the presentation of a model based upon the concept of environmental heterogeneity. The essence of the model, which is equally applicable to haploid and diploid situations, is a shifting distribution of multiple adaptive niches among local populations such that a given population has a small net selective pressure in favor of one allele or another, depending upon its particular distribution of niches. Gene flow among neighboring populations with differing net selective pressures is postulated as the principal factor underlying intrapopulational allozyme variation.

scholarly journals Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

2021 ◽  
Vol 14 (7) ◽  
pp. 603
Author(s):  
Vanesa Pérez-Laguna ◽  
Isabel García-Luque ◽  
Sofía Ballesta ◽  
Antonio Rezusta ◽  
Yolanda Gilaberte
Keyword(s):  
Photodynamic Therapy ◽  
Soft Tissues ◽  
Combined Treatment ◽  
Resistance Pattern ◽  
Antimicrobial Photodynamic Therapy ◽  
Antimicrobial Drugs ◽  
Bacteria And Fungi ◽  
High Level ◽  
Selection Of

The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.

scholarly journals Genetic variation in the dietary sucrose modulation of enzyme activities in Drosophila melanogaster

1984 ◽  
Vol 43 (3) ◽  
pp. 307-321 ◽  
Author(s):  
Billy W. Geer ◽  
Cathy C. Laurie-Ahlberg
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Variation ◽  
Enzyme Activities ◽  
Glycogen Synthesis ◽  
Krebs Cycle ◽  
Natural Populations ◽  
Substitution Lines ◽  
Chromosome Substitution Lines ◽  
High Sucrose Diet ◽  
Selection Of

SUMMARYGenetic variation in the modulating effect of dietary sucrose was assessed in Drosophila melanogaster by examining 27 chromosome substitution lines coisogenic for the X and second chromosomes and possessing different third isogenic chromosomes derived from natural populations. An increase in the concentration of sucrose from 0·1% to 5% in modified Sang's medium C significantly altered the activities of 11 of 15 enzyme activities in third instar larvae, indicating that dietary sucrose modulates many, but not all, of the enzymes of D. melanogaster. A high sucrose diet promoted high activities of enzymes associated with lipid and glycogen synthesis and low activities of enzymes of the glycolytic and Krebs cycle pathways, reflecting the physiological requirements of the animal. Analyses of variance revealed significant genetic variation in the degrees to which sucrose modulated several enzyme activities. Analysis of correlations revealed some relationships between enzymes in the genetic effects on the modulation process. These observations suggest that adaptive evolutionary change may depend in part on the selection of enzyme activity modifiers that are distributed throughout the genome.

Clarifying Institutional and Organizational Conditions Promoting Principals' Quality Leadership and Reform Design for Japan

Impact ◽  
2021 ◽  
Vol 2021 (7) ◽  
pp. 15-17
Author(s):  
Hirofumi Hamada
Keyword(s):  
Education Reform ◽  
Developed Countries ◽  
Vital Role ◽  
Quality Of Education ◽  
Organizational Conditions ◽  
Problem Situations ◽  
Distributed Approach ◽  
Area Of Interest ◽  
High Level

Education reform helps ensure that the education in a given country is of the highest possible quality and is a key area of focus for many developed countries. Japan's education system rates highly and the evolution of education reform is key to ensuring this high level is sustained. School principals play a key role in delivering high-quality education and, indeed, a school principal's leadership correlates with the quality of education available. This is an area of interest for Professor Hirofumi Hamada, School Management Laboratory in the Faculty of Human Sciences, University of Tsukuba, Japan, who is currently exploring the institutional and organisational conditions that affect the leadership of principals. The goal of this research is to help shape education reform in Japan. Hamada believes it is necessary to create an environment of independent and collaborative learning and to value the individuality of children. In addition, problem situations among children are diverse and complex and how schools respond influences the quality of education. Given that the principal is in charge of how a school is run, they play a vital role in assuring the quality of education. Key to Hamada's work is the idea that principals can share their knowledge and leadership with teachers and this creates an environment of shared leadership. He believes that empowering teachers and encouraging them to take on leadership duties is essential. He is working to inform educators that schools require the leadership of principals and for principals to promote a distributed approach to leadership.

GIS Based Multi-Criteria decision support system and machine learning for Hospital Site Selection case study Oran - Algeria

2022 ◽  
Vol 14 (1) ◽  
pp. 0-0
Keyword(s):  
Site Selection ◽  
Decision Makers ◽  
Analysis Method ◽  
Automatic Learning ◽  
Hospital Site ◽  
Set Up ◽  
High Level ◽  
Selection Of ◽  
The Ideal

The selection of hospital sites is one of the most important choice a decision maker has to take so as to resist the pandemic. The decision may considerably affect the outbreak transmission in terms of efficiency , budget, etc. The main targeted objective of this study is to find the ideal location where to set up a hospital in the willaya of Oran Alg. For this reason, we have used a geographic information system coupled to the multi-criteria analysis method AHP in order to evaluate diverse criteria of physiological positioning , environmental and economical. Another objective of this study is to evaluate the advanced techniques of the automatic learning . the method of the random forest (RF) for the patterning of the hospital site selection in the willaya of Oran. The result of our study may be useful to decision makers to know the suitability of the sites as it provides a high level of confidence and consequently accelerate the power to control the COVID19 pandemic.

Genetic variation in an orchardgrass population promises successful direct or indirect selection of superior drought tolerant genotypes

2018 ◽  
Vol 137 (6) ◽  
pp. 928-935 ◽  
Author(s):  
Mozhgan Abtahi ◽  
Mohammad Mahdi Majidi ◽  
Behnam Hoseini ◽  
Aghafakhr Mirlohi ◽  
Bahram Araghi ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Indirect Selection ◽  
Drought Tolerant ◽  
Selection Of

Fern speciation and biogeography

1985 ◽  
Vol 86 ◽  
pp. 353-360 ◽  
Author(s):  
Rolla Tryon
Keyword(s):  
New Species ◽  
Parental Species ◽  
Local Environment ◽  
Limited Range ◽  
Ecological Adaptation ◽  
Species Selection ◽  
Potential Range ◽  
Small Range ◽  
Extensive Range ◽  
Selection Of

SynopsisThe most common kinds of speciation result in new species that initially have a small range. These will develop a limited or an extensive range depending upon the geographic extent of the environment to which they are adapted. A significant element in the extent of the potential range of a new species is the adaptation inherited from the parental species. Selection of a parental species for a local environment at one site can lead to a narrow ecological adaptation and often to a limited potential range. These species are likely to produce derived ones that also have a limited range, and these derivates will increase the regional species endemism and diversity. Selection of a parental species for migration to other sites can lead to a broader ecological adaptation and often to a broad potential range. These species are more likely to produce derived ones that also have an extensive range, and these derivates will increase regional species diversity.

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