scholarly journals Ischemic Postconditioning after Stroke: Another Concept for the Trigeminocardiac Reflex?

10.5772/65201 ◽  
2016 ◽  
Author(s):  
Nora Sandu ◽  
Bernhard Schaller
Keyword(s):  
Ischemic Postconditioning ◽  
Trigeminocardiac Reflex

scholarly journals Remote Ischemic Postconditioning vs. Physical Exercise After Stroke: an Alternative Rehabilitation Strategy?

2021 ◽  
Author(s):  
Xiaokun Geng ◽  
Qingzhu Wang ◽  
Hangil Lee ◽  
Christian Huber ◽  
Melissa Wills ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Treadmill Exercise ◽  
Infarct Volume ◽  
Ischemic Postconditioning ◽  
Synaptic Proteins ◽  
Neurological Deficits ◽  
Sprague Dawley ◽  
Neurobehavioral Function ◽  
Remote Ischemic Postconditioning ◽  
Function Tests

AbstractThere remain debates on neuroprotection and rehabilitation techniques for acute ischemic stroke patients. Therapeutic physical exercise following stroke has shown promise but is challenging to apply clinically. Ischemic conditioning, which has several clinical advantages, is a potential neuroprotective method for stroke rehabilitation that is less understood. In the present study, the rehabilitative properties and mechanisms of physical exercise and remote ischemic postconditioning (RIPostC) after stroke were compared and determined. A total of 248 adult male Sprague-Dawley rats were divided into five groups: (1) sham, (2) stroke, (3) stroke with intense treadmill exercise, (4) stroke with mild treadmill exercise, and (5) stroke with RIPostC. Focal ischemia was evaluated by infarct volume and neurological deficit. Long-term functional outcomes were represented through neurobehavioral function tests: adhesive removal, beam balance, forelimb placing, grid walk, rota-rod, and Morris water maze. To further understand the mechanisms underlying neurorehabilitation and verify the presence thereof, we measured mRNA and protein levels of neuroplasticity factors, synaptic proteins, angiogenesis factors, and regulation molecules, including HIF-1α, BDNF, TrkB, and CREB. The key role of HIF-1α was elucidated by using the inhibitor, YC-1. Both exercise intensities and RIPostC significantly decreased infarct volumes and neurological deficits and outperformed the stroke group in the neurobehavioral function tests. All treatment groups showed significant increases in mRNA and protein expression levels of the target molecules for neurogenesis, synaptogenesis, and angiogenesis, with intermittent further increases in the RIPostC group. HIF-1α inhibition nullified most beneficial effects and indicative molecule expressions, including HIF-1α, BDNF, TrkB, and CREB, in both procedures. RIPostC is equally, or superiorly, effective in inducing neuroprotection and rehabilitation compared to exercise in ischemic rats. HIF-1α likely plays an important role in the efficacy of neuroplasticity conditioning, possibly through HIF-1α/BDNF/TrkB/CREB regulation.

scholarly journals Acute administration of the olive constituent, oleuropein, combined with ischemic postconditioning increases myocardial protection by modulating oxidative defense

2021 ◽  
Vol 166 ◽  
pp. 18-32
Author(s):  
Maria Tsoumani ◽  
Anastasios Georgoulis ◽  
Panagiota-Efstathia Nikolaou ◽  
Ioannis V. Kostopoulos ◽  
Theano Dermintzoglou ◽  
...  
Keyword(s):  
Myocardial Protection ◽  
Ischemic Postconditioning ◽  
Acute Administration ◽  
Oxidative Defense

Critical role of age, strain and number of cycles in ischemic postconditioning

2007 ◽  
Vol 42 (6) ◽  
pp. S186-S187 ◽  
Author(s):  
Sarin Somers ◽  
Lydia Lacerda ◽  
Naushaad Suleman ◽  
Lionel Opie ◽  
Sandrine Lecour
Keyword(s):  
Critical Role ◽  
Ischemic Postconditioning ◽  
Number Of Cycles

Ischemic postconditioning in cerebral ischemia: Differences between the immature and mature brain?

2015 ◽  
Vol 45 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Pierre‐Louis Leger ◽  
Philippe Bonnin ◽  
Sylvain Renolleau ◽  
Olivier Baud ◽  
Christiane Charriaut‐Marlangue
Keyword(s):  
Cerebral Ischemia ◽  
Ischemic Postconditioning ◽  
Mature Brain

scholarly journals GW26-e2184 The short- and long-term effects of ischemic postconditioning in STEMI patients:a meta-analysis

2015 ◽  
Vol 66 (16) ◽  
pp. C141-C142
Author(s):  
Jing Gao ◽  
Fen Liu ◽  
Yingying Zheng ◽  
Bangdang Chen ◽  
Qingjie Chen ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Ischemic Postconditioning ◽  
Long Term Effects ◽  
Short And Long Term

scholarly journals F006 Critical role of ERK1/2 in erythropoietin-mediated cardioprotection compared with ischemic postconditioning

2009 ◽  
Vol 102 ◽  
pp. S55
Author(s):  
N. Ghaboura ◽  
S. Tamareille ◽  
F. Treguer ◽  
D. Khachman ◽  
D. Henrion ◽  
...  
Keyword(s):  
Critical Role ◽  
Ischemic Postconditioning
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