scholarly journals ZnO Nanoparticles: A Promising Anticancer Agent

10.5772/63437 ◽  
2016 ◽  
Vol 3 ◽  
pp. 9 ◽  
Author(s):  
Gunjan Bisht ◽  
Sagar Rayamajhi
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Zno Nanoparticles ◽  
Cell Cycle Progression ◽  
Anticancer Agent ◽  
Zinc Concentration ◽  
Cancer Therapies ◽  
Protein Activity ◽  
High Zinc ◽  
High Zinc Concentration

Nanoparticles, with their selective targeting capabilities and superior efficacy, are becoming increasingly important in modern cancer therapy and starting to overshadow traditional cancer therapies such as chemotherapy radiation and surgery. ZnO nanoparticles, with their unique properties such as biocompatibility, high selectivity, enhanced cytotoxicity and easy synthesis, may be a promising anticancer agent. Zinc, as one of the major trace elements of the human body and co-factor of more than 300 mammalian enzymes, plays an important role in maintaining crucial cellular processes including oxidative stress, DNA replication, DNA repair, cell cycle progression and apoptosis. Thus, it is evident that an alteration in zinc levels in cancer cells can cause a deleterious effect. Research has shown that low zinc concentration in cells leads to the initiation and progression of cancer and high zinc concentration shows toxic effects. Zinc-mediated protein activity disequilibrium and oxidative stress through reactive oxygen species (ROS) may be the probable mechanism of this cytotoxic effect. The selective localization of ZnO nanoparticles towards cancer cells due to enhanced permeability and retention (EPR) effect and electrostatic interaction and selective cytotoxicity due to increased ROS present in cancer cells show that ZnO nanoparticles can selectively target and kill cancer cells, making them a promising anticancer agent.

scholarly journals Characterization and Identification of Cryptic Biopeptides inCarya illinoinensis(Wangenh K. Koch) Storage Proteins

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Everardo Mares-Mares ◽  
Santiago Gutiérrez-Vargas ◽  
Luis Pérez-Moreno ◽  
Leandro G. Ordoñez-Acevedo ◽  
José E. Barboza-Corona ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Bioactive Peptides ◽  
Storage Proteins ◽  
Biological Activities ◽  
Cancer Therapies ◽  
In Silico Prediction ◽  
Major Fraction ◽  
Cycle Progression ◽  
Cervical Cancer Cells

The objective of this research was to identify and characterize the encoded peptides present in nut storage proteins ofCarya illinoinensis. It was found, through in silico prediction, proteomic analysis, and MS spectrometry, that bioactive peptides were mainly found in albumin and glutelin fractions. Glutelin was the major fraction with ~53% of the nut storage proteins containing at least 21 peptides with different putative biological activities, including antihypertensives, antioxidants, immunomodulators, protease inhibitors, and inhibitors of cell cycle progression in cancer cells. Data showed that using 50 μg/mL tryptic digests of enriched peptides obtained from nut glutelins is able to induce up to 19% of apoptosis in both HeLa and CasKi cervical cancer cells. To our knowledge, this is the first report that shows the potential value of the nut-encoded peptides to be considered as adjuvants in cancer therapies.

scholarly journals High Zinc Concentration in Common Carp Viscera

1974 ◽  
Vol 40 (5) ◽  
pp. 509-509 ◽  
Author(s):  
Sen Shyong JENG ◽  
Hsiu Wan Lo
Keyword(s):  
Common Carp ◽  
Zinc Concentration ◽  
High Zinc ◽  
High Zinc Concentration

EMPIRICAL ESTIMATES OF PHYSICAL PARAMETERS FROM ELECTRICAL RESISTIVITY MEASUREMENTS ON FERRITES

1996 ◽  
Vol 10 (07) ◽  
pp. 299-303
Author(s):  
MISBAH UL ISLAM ◽  
M. SHAKEEL BILAL ◽  
T. ABBAS ◽  
M.U. RANA ◽  
S. MOHSIN RAZA
Keyword(s):  
Electrical Resistivity ◽  
High Temperatures ◽  
Zinc Concentration ◽  
Physical Parameters ◽  
Resistivity Measurements ◽  
Temperature Range ◽  
Octahedral Sites ◽  
Empirical Estimates ◽  
High Zinc ◽  
High Zinc Concentration

Measurements on the electrical resistivity of Mn 1−x Zn x Fe 2 O 4 ferrites with 0<x< 0.15 in the temperature range 300 K <T<450 K , have been carried out. Analysis of the normalised electrical resistivity of these ferrites shows deviations from linearity both at low and high temperatures. There exists a deviation in the electrical resistivity at 300 K at high zinc concentration which may be due to hopping of electrons between Fe +2 and Fe +3 ions at octahedral sites.

Effects of high zinc concentration on poplar leaves: A morphological and biochemical study

2011 ◽  
Vol 71 (1) ◽  
pp. 50-56 ◽  
Author(s):  
V. Todeschini ◽  
G. Lingua ◽  
G. D’Agostino ◽  
F. Carniato ◽  
E. Roccotiello ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Biochemical Study ◽  
High Zinc ◽  
High Zinc Concentration ◽  
Poplar Leaves

ZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7 cancer cells and their antibacterial activity

2014 ◽  
Vol 117 ◽  
pp. 267-276 ◽  
Author(s):  
Rizwan Wahab ◽  
Maqsood A. Siddiqui ◽  
Quaiser Saquib ◽  
Sourabh Dwivedi ◽  
Javed Ahmad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antibacterial Activity ◽  
Cancer Cells ◽  
Zno Nanoparticles ◽  
Mcf 7

scholarly journals Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells

2019 ◽  
Author(s):  
Yousef Alharbi ◽  
Arvinder Kapur ◽  
Mildred Felder ◽  
Lisa Barroilhet ◽  
Timothy Stein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Oxygen Radicals ◽  
Outward Current ◽  
Radical Scavenger ◽  
Cancer Therapies ◽  
Drug Induced ◽  
Whole Cell Patch Clamp ◽  
Short Term Exposure ◽  
Canine Cancer

AbstractThe Na+/K+-ATPase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapies. Here, we investigate the effect of drug-induced oxidative stress on NKA activity. The natural product, plumbagin increases oxygen radicals through inhibition of oxidative phosphorylation. As a result, plumbagin treatment results in decreased production of ATP and a rapid increase in intracellular oxygen radicals. We show that plumbagin induces apoptosis in canine cancer cells via oxidative stress. We use this model to test the effect of oxidative stress on NKA activity. Using whole-cell patch-clamp electrophysiology we demonstrate that short-term exposure (4 min) to plumbagin results in 48% decrease in outward current at +50 mV. Even when exogenous ATP was supplied to the cells, plumbagin treatment resulted in 46% inhibition outward current through NKA at +50 mV. In contrast, when the canine cancer cells were pre-treated with the oxygen radical scavenger, N-acetylcysteine, the NKA inhibitory activity of plumbagin was abrogated. These experiments demonstrate that the oxidative stress-causing agents such as plumbagin and its analogues, are a novel avenue to regulate NKA activity in tumors.

scholarly journals Distinctive expression of a zinc-binding protein in rice callus grown in medium with high zinc concentration

2000 ◽  
Vol 46 (1) ◽  
pp. 209-216 ◽  
Author(s):  
Yuichi Saeki ◽  
Ayako Yasukouchi ◽  
Yoshitaka Nagatomo ◽  
Hiroshi Takaki
Keyword(s):  
Zinc Concentration ◽  
Binding Protein ◽  
Zinc Binding ◽  
Rice Callus ◽  
High Zinc ◽  
High Zinc Concentration

Anoxia survival in common carp and crucian carp is related to high zinc concentration in tissues

2008 ◽  
Vol 74 (3) ◽  
pp. 627-634 ◽  
Author(s):  
Sen Shyong JENG ◽  
Tzu Yung LIN ◽  
Ming Shyong WANG ◽  
Yu Yin CHANG ◽  
Chao Yi CHEN ◽  
...  
Keyword(s):  
Common Carp ◽  
Crucian Carp ◽  
Zinc Concentration ◽  
High Zinc ◽  
High Zinc Concentration
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