scholarly journals The Impact of Graphene Oxide on Bone Regeneration Therapies

10.5772/63333 ◽  
2016 ◽  
Author(s):  
Anca Hermenean ◽  
Sorina Dinescu ◽  
Mariana Ionita ◽  
Marieta Costache
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
The Impact

Effects of pH shock on microaerobic activated sludge system with a graphene oxide/nano-magnetic powder composite

2020 ◽  
Vol 35 (3) ◽  
pp. 457-463
Author(s):  
Huixia Lan ◽  
Xiangzhi Wang ◽  
Shixin Qi ◽  
Da Yang ◽  
Hao Zhang
Keyword(s):  
Graphene Oxide ◽  
Activated Sludge ◽  
High Throughput Sequencing ◽  
Impact Resistance ◽  
Magnetic Powder ◽  
Blank Group ◽  
Activated Sludge System ◽  
Ph Shock ◽  
Dominant Bacteria ◽  
The Impact

AbstractUsing the acclimated activated sludge from the pulping middle-stage effluent, the effect of pH shock on the micro-oxygen activated sludge system with a nano-magnetic powder/graphene oxide composite was studied. The results showed that the removal rates of chemical oxygen demand (CODCr) and ultraviolet adsorption at 254 nm (UV254) decreased. Also, the sludge settling performance was poor due to the impact of pH, but the impact resistance of nano-magnetic powder/graphene oxide group (MGO group) was higher and the recovery was faster. Results of high throughput sequencing indicated that the diversity of microbial community was reduced by the impact of pH, but it was significantly higher in MGO group than in the blank group. The dominant bacteria after pH shock or recovery in both of the system had a large difference. The percentage of the dominant bacteria in the MGO group was higher than that in the blank group. The MGO group had higher electron transfer system (ETS) activity which made the system having a strong pH impact resistance.

Preparation and properties of novel sulfonic graphene oxide–epoxy resin nanocomposites by resin transfer molding process

2016 ◽  
Vol 51 (9) ◽  
pp. 1197-1208 ◽  
Author(s):  
Wei Li ◽  
Hongyu Li ◽  
Xinguo Yang ◽  
Wei Feng ◽  
Hongyun Huang
Keyword(s):  
Graphene Oxide ◽  
Impact Strength ◽  
Epoxy Resin ◽  
Curing Temperature ◽  
Flexural Property ◽  
Oxide Content ◽  
Molding Process ◽  
One Pot ◽  
Epoxy Resin Nanocomposites ◽  
The Impact

This paper reported a facile one-pot strategy for fabrication of sulfonic graphene oxide–epoxy resin nanocomposites. The rheological and thermal properties were employed to characterize the viscosity and the curing temperature of epoxy resin. Fourier transform infrared spectra for sulfonic graphene oxide and nanocomposites indicated that the sulfonic graphene oxide contains chemical cross-linking responsible for better interactions with the epoxy resin. The state of dispersion was evaluated at different scales by still picture camera and scanning electron microscopy (SEM). Tensile property tests indicated that the tensile strength and elasticity modulus of sulfonic graphene oxide–epoxy resin nanocomposites decreased slowly with increasing of sulfonic graphene oxide content. The critical flexural property and impact strength of epoxy resin filled with sulfonic graphene oxide nanocomposites were measured. The content, size, and dispersion state of sulfonic graphene oxide were examined. It was found that the content of sulfonic graphene oxide has greater impact on both flexural property and impact strength of nanocomposites compared with other conditions. For instance, the impact strength increased by 113.0% and the flexural strength and modulus increased by 39.3% and 55.7% using 1 wt.% sulfonic graphene oxide as compared to neat epoxy resin.

Graphene: Insights on Biological, Radiochemical and Ecotoxicological Aspects

2021 ◽  
Vol 17 (1) ◽  
pp. 131-148
Author(s):  
Xing Haixia ◽  
Aline Oliveira da Silva de Barros ◽  
Francisco do Vale Chaves e Mello ◽  
Fan Sozzi-Guo ◽  
Cristina Müller ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Graphene Quantum Dots ◽  
Covalent Bonds ◽  
Cell Internalization ◽  
Functional Density Theory ◽  
Ecotoxicological Evaluation ◽  
Plasmatic Membrane ◽  
Low Toxicity ◽  
The Impact

Graphene, including graphene quantum dots, its oxide and unoxidized forms (pure graphene) have several properties, like fluorescence, electrical conductivity, theoretical surface area, low toxicity, and high biocompatibility. In this study, we evaluated genotoxicity (in silico analysis using the functional density theory-FDT), cytotoxicity (human glioblastoma cell line), in vivo pharmacokinetics, in vivo impact on microcirculation and cell internalization assay. It was also radiolabeled with lutetium 177 (177Lu), a beta emitter radioisotope to explore its therapeutic use as nanodrug. Finally, the impact of its disposal in the environment was analyzed using ecotoxicological evaluation. FDT analysis demonstrated that graphene can construct covalent and non-covalent bonds with different nucleobases, and graphene oxide is responsible for generation of reactive oxygen species (ROS), corroborating its genotoxicity. On the other hand, non-cytotoxic effect on glioblastoma cells could be demonstrated. The pharmacokinetics analysis showed high plasmatic concentration and clearance. Topical application of 0.1 and 1 mg/kg of graphene nanoparticles on the hamster skinfold preparation did not show inflammatory effect. The cell internalization assay showed that 1-hour post contact with cells, graphene can cross the plasmatic membrane and accumulate in the cytoplasm. Radio labeling with 177Lu is possible and its use as therapeutic nanosystem is viable. Finally, the ecotoxicity analysis showed that A. silina exposed to graphene showed pronounced uptake and absorption in the nauplii gut and formation of ROS. The data obtained showed that although being formed exclusively of carbon and carbon-oxygen, graphene and graphene oxide respectively generate somewhat contradictory results and more studies should be performed to certify the safety use of this nanoplatform.

COMPUTATIONAL MODELING OF EPOXY-BASED HYBRID COMPOSITES REINFORCED WITH CARBON FIBERS AND FUNCTIONALIZED GRAPHENE NANOPLATELETS

2021 ◽  
Author(s):  
HASHIM AL MAHMUD ◽  
, MATTHEW RADUE ◽  
WILLIAM PISANI ◽  
GREGORY ODEGARD
Keyword(s):  
Mechanical Properties ◽  
Graphene Oxide ◽  
Hybrid Composites ◽  
Graphene Nanoplatelets ◽  
Pristine Graphene ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Aspect Ratios ◽  
The Impact ◽  
Nanoscale Level

The impact on the mechanical properties of unidirectional carbon fiber (CF)/epoxy composites reinforced with pristine graphene nanoplatelets (GNP), highly concentrated graphene oxide (GO), and Functionalized Graphene Oxide (FGO) are investigated in this study. The localized reinforcing effect of each of the graphene nanoplatelet types on the epoxy matrix is predicted at the nanoscale-level by molecular dynamics. The bulk-level mechanical properties of unidirectional CF/epoxy hybrid composites are predicted using micromechanics techniques considering the reinforcing function, content, and aspect ratios for each of the graphene nanoplatelets. In addition, the effect of nanoplatelets dispersion level is also investigated for the pristine graphene nanoplatelets considering a lower dispersion level with four layers of graphene nanoplatelets (4GNP). The results indicate that the shear and transverse properties are significantly affected by the nanoplatelet type, loading and aspect ratio. The results of this study can be used in the design of hybrid composites to tailor specific laminate properties by adjusting nanoplatelet parameters.

scholarly journals Cisplatin-Loaded Graphene Oxide/Chitosan/Hydroxyapatite Composite as a Promising Tool for Osteosarcoma-Affected Bone Regeneration

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 14620-14633 ◽  
Author(s):  
Murugan Sumathra ◽  
Kishor Kumar Sadasivuni ◽  
S. Suresh Kumar ◽  
Mariappan Rajan
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
Promising Tool ◽  
Hydroxyapatite Composite

scholarly journals Effects of Co-Culture of Graphene Oxide Scaffolds with Different Concentrations and Umbilical Mesenchymal Stem Cells on the Proliferation and Differentiation of Stem Cells

2021 ◽  
Author(s):  
Aifeng Liu ◽  
Jixin Chen ◽  
Shuwei Gong ◽  
Qiang Wei ◽  
Ye Yuan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Umbilical Cord ◽  
High Porosity ◽  
Proliferation And Differentiation ◽  
Scaffold Materials ◽  
The Impact

Abstract The main role of the scaffold materials is to enable cells to survive in the scaffold binding as while as to further promote their proliferation and differentiation ability. For mesenchymal stem cell, the scaffold could provide an environment for them to maintain their phenotype, and synthesize all necessary molecules and proteins. Generally, scaffold materials for stem cell need to possess basic characteristics such as high porosity, large surface area, surface rigidity and biodegradability. Thus, the two-dimensional graphene oxide (GO) with oxygen-containing functional groups may be suitable scaffold materials for mesenchymal stem cell culture.MethodsIn this study, the effect of GO on the value-added differentiation activity of mesenchymal stem cell was systematically investigated. ResultsIt was found that low concentration of GO and sufficient concentration of umbilical cord mesenchymal stem cells are suitable for the second Co-culture. Furthermore, the addition of hyaluronic acid will make this culture more evenly distributed. ConclusionsThe adsorption of GO on umbilical cord mesenchymal stem cells can also make the two closely linked, which avoids the impact of animal joint activities on cells.

The impact of immobilization of BMP-2 on PDO membrane for bone regeneration

2012 ◽  
Vol 100A (6) ◽  
pp. 1488-1493 ◽  
Author(s):  
Ji-Eun Kim ◽  
Eun-Jung Lee ◽  
Hyoun-Ee Kim ◽  
Young-Hag Koh ◽  
Jun-Hyeog Jang
Keyword(s):  
Bone Regeneration ◽  
The Impact

scholarly journals Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGA/Graphene Oxide Hybrid Fiber Matrices and Electrical Stimulation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Jiaqi Zhu ◽  
Zhiping Qi ◽  
Changjun Zheng ◽  
Pan Xue ◽  
Chuan Fu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Graphene Oxide ◽  
Electrical Stimulation ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Cellular Response ◽  
Hybrid Fiber ◽  
Fiber Matrices

Bone tissue engineering scaffold provides an effective treatment for bone defect repair. Biodegradable bone scaffold made of various synthetic and natural materials can be used as bone substitutes and grafts for defect site, which has great potential to support bone regeneration. Regulation of cell-scaffold material interactions is an important factor for modulating the cellular activity in bone tissue engineering scaffold applications. Thus, the hydrophilic, mechanical, and chemical properties of scaffold materials directly affect the results of bone regeneration and functional recovery. In this study, a poly-L-lysine (PLL) surface-modified poly(lactic-co-glycolic acid) (PLGA)/graphene oxide (GO) (PLL-PLGA/GO) hybrid fiber matrix was fabricated for bone tissue regeneration. Characterization of the resultant hybrid fiber matrices was done using scanning electron microscopy (SEM), contact angle, and a material testing machine. According to the results obtained from the test above, the PLL-PLGA/GO hybrid fiber matrices exhibited high wettability and mechanical strength. The special surface characteristics of PLL-PLGA/GO hybrid fiber matrices were more beneficial for protein adsorption and inhibit the proliferation of pathogens. Moreover, the enhanced regulation of MC3T3-E1 cell proliferation and differentiation was observed, when the resultant hybrid fiber matrices were combined with electrical stimulation (ES). The cellular response of MC3T3-E1 cells including cell adhesion, proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and osteogenesis-related gene expression was significantly enhanced with the synergistic effect of resultant hybrid fiber matrices and ES. These data indicate that the PLL-PLGA/GO hybrid fiber matrices supported the cellular response in terms of cell proliferation and osteogenesis differentiation in the presence of electrical stimulation, which could be a potential treatment for bone defect.

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