scholarly journals Regenerative Medicine: A New Paradigm in Bone Regeneration

10.5772/62523 ◽  
2016 ◽  
Author(s):  
Orlando Chaparro ◽  
Itali Linero
Keyword(s):  
Regenerative Medicine ◽  
Bone Regeneration ◽  
New Paradigm

Aerogels for Biomedical Applications

2021 ◽  
pp. 23-42
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Biomedical Applications ◽  
Implantable Devices ◽  
Strategic Development ◽  
The World ◽  
Biomedical Field ◽  
Materials Used

The researchers across the world are actively engaged in strategic development of new porous aerogel materials for possible application of these extraordinary materials in the biomedical field. Due to their excellent porosity and established biocompatibility, aerogels are now emerging as viable solutions for drug delivery and other biomedical applications. This chapter aims to cover the diverse aerogel materials used across the globe for different biomedical applications including drug delivery, implantable devices, regenerative medicine encompassing tissue engineering and bone regeneration, and biosensing.

The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

2019 ◽  
Vol 46 ◽  
pp. 1-9 ◽  
Author(s):  
Praveen Kumar L. ◽  
Sangeetha Kandoi ◽  
Ranjita Misra ◽  
Vijayalakshmi S. ◽  
Rajagopal K. ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Mesenchymal Stem Cell ◽  
New Paradigm

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

Nanoscale ◽  
2019 ◽  
Vol 11 (37) ◽  
pp. 17230-17234
Author(s):  
Aijun Li ◽  
Yu Fan ◽  
Xueyan Cao ◽  
Liang Chen ◽  
Le Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Potential Applications

Morpholino-functionalized phosphorus dendrimers strongly promote the transformation of mesenchymal stem cells into osteoblasts for potential applications in bone regeneration.

Current technological platforms of translational and regenerative medicine as new paradigm of post-MI patients management

2015 ◽  
Vol 8 (6) ◽  
pp. 98
Author(s):  
D. Cherepakhin ◽  
Yu. Belov ◽  
P. Shved ◽  
Yu. Bukina ◽  
A. Lichtenberg ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
New Paradigm ◽  
Technological Platforms

Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair

2018 ◽  
Vol 6 (1) ◽  
pp. 60-78 ◽  
Author(s):  
I. M. Bjørge ◽  
S. Y. Kim ◽  
J. F. Mano ◽  
B. Kalionis ◽  
W. Chrzanowski
Keyword(s):  
Regenerative Medicine ◽  
Extracellular Vesicles ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
New Paradigm ◽  
Ribonucleic Acids ◽  
Biological Signals

Extracellular vesicles are highly specialized messengers that deliver vital biological signals including ribonucleic acids – key modulators in tissue regeneration.

scholarly journals Autobionics: a new paradigm in regenerative medicine and surgery

2010 ◽  
Vol 5 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Hutan Ashrafian ◽  
Ara Darzi ◽  
Thanos Athanasiou
Keyword(s):  
Regenerative Medicine ◽  
New Paradigm

Multiscale osteointegration as a new paradigm for the design of calcium phosphate scaffolds for bone regeneration

Biomaterials ◽  
2010 ◽  
Vol 31 (13) ◽  
pp. 3552-3563 ◽  
Author(s):  
Sheeny K. Lan Levengood ◽  
Samantha J. Polak ◽  
Matthew B. Wheeler ◽  
Aaron J. Maki ◽  
Sherrie G. Clark ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
New Paradigm

Regenerative medicine of oral tissue: clinical trial of alveolar bone regeneration and regeneration of blood vessels and peripheral nerves

Toukeibu Gan ◽  
2007 ◽  
Vol 33 (3) ◽  
pp. 238-243
Author(s):  
Hideaki Kagami ◽  
Izumi Asahina ◽  
Hideki Agata ◽  
Yuji Narita ◽  
Noriyuki Yamamoto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Blood Vessels ◽  
Peripheral Nerves ◽  
Alveolar Bone ◽  
Oral Tissue

scholarly journals Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling

2020 ◽  
Vol 6 (24) ◽  
pp. eaba7602
Author(s):  
Ziad Julier ◽  
Rezvan Karami ◽  
Bhavana Nayer ◽  
Yen-Zhen Lu ◽  
Anthony J. Park ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factors ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Interleukin 1 ◽  
Delivery Systems ◽  
Regenerative Capacity ◽  
Local Inhibition ◽  
Signaling Dynamics ◽  
Regenerative Activity

Although growth factors (GFs) are key molecules for regenerative medicine, their use has been limited by issues associated with suboptimal delivery systems and incomplete understanding of their signaling dynamics. Here, we explored how proinflammatory signals affect GF regenerative potential. Using bone regeneration in mouse, we found that the regenerative capacity of two clinically relevant GFs (BMP-2 and PDGF-BB) is impaired by interleukin-1 receptor (IL-1R1). Mechanistically, IL-1R1 activation in bone-forming cells desensitizes them to GFs and accelerates senescence. Moreover, administration of the GFs triggers IL-1 release by macrophages. To provide localized and sustained IL-1R1 inhibition, we engineered IL-1R antagonist (IL-1Ra) to bind the extracellular matrix (ECM) very strongly and demonstrate that codelivering GFs with ECM-binding IL-1Ra induces superior regeneration. Thus, we highlight that GF regenerative activity is hindered by proinflammatory signals, and GF-based therapies should integrate immunomodulation. Particularly, ECM-binding IL-1Ra holds clinical translational potential by enhancing efficacy of GF therapies.

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