scholarly journals Green Tea Catechins for Prostate Cancer Chemoprevention

Author(s):  
Ganna Chornokur ◽  
Nagi B. Kumar
2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Nagi B. Kumar ◽  
Julio Pow-Sang ◽  
Kathleen Egan ◽  
Philippe E. Spiess ◽  
Shohreh I Dickinson ◽  
...  

Author(s):  
S Bettuzzi ◽  
F Rizzi

Clinical progression of Prostate Cancer (CaP) is variable: some tumours are indolent, others rapidly progress. Because, diagnosis is usually in elderly men, CaP is an ideal target for chemoprevention. We showed that Green Tea Catechins (GTC) possess anti-tumour activity, suggesting that it might be beneficial in the early stages of cell transformation. But an experimental confirmation in a real clinical setting was needed. High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) is a pre-invasive stage of CaP for which no treatment options are available until CaP is diagnosed.


Author(s):  
Gianpaolo Perletti ◽  
Vittorio Magri ◽  
Anne Vral ◽  
Konstantinos Stamatiou ◽  
Alberto Trinchieri

A focused, single outcome meta-analysis on the protective role of extracts of green tea catechins against prostate cancer. Randomized, placebo-controlled studies enrolling patients with a histologically confirmed diagnosis of high-grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar proliferation but no prostate cancer were included. Meta-analysis for binary data was performed using Mantel-Haenszel statistics, using a random-effects model. Heterogeneity was investigated by calculating the I2. Four studies matched the inclusion criteria for the review. The pooled population was 223 patients; 114 and 109 patients were randomized to catechin and placebo groups, respectively. Nine cases of prstate cancer occurred in the catechin arm (7.9%), and 24 cases were reported in the placebo arm (22%). Pooled analysis resulted in a significant reduction of cancer risk in favor of the catechin arm (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0). In conclusion, our data suggest that the intake of concentrated green tea catechin preparations may confer a significant protective effect to carriers of early neoplastic lesions in the prostate. The quality of the evidence is moderate, and additional, largescale studies are warranted to substantiate these preliminary findings.


2018 ◽  
Vol 11 (11) ◽  
pp. 687-696 ◽  
Author(s):  
J. Athene Lane ◽  
Vanessa Er ◽  
Kerry N.L. Avery ◽  
Jeremy Horwood ◽  
Marie Cantwell ◽  
...  

Life Sciences ◽  
2001 ◽  
Vol 68 (10) ◽  
pp. 1207-1214 ◽  
Author(s):  
L.Y. Chung ◽  
T.C. Cheung ◽  
S.K. Kong ◽  
K.P. Fung ◽  
Y.M. Choy ◽  
...  

2011 ◽  
Vol 55 (6) ◽  
pp. 832-843 ◽  
Author(s):  
Masahito Shimizu ◽  
Seiji Adachi ◽  
Muneyuki Masuda ◽  
Osamu Kozawa ◽  
Hisataka Moriwaki

Antioxidants ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 26 ◽  
Author(s):  
Valeria Naponelli ◽  
Ileana Ramazzina ◽  
Chiara Lenzi ◽  
Saverio Bettuzzi ◽  
Federica Rizzi

2012 ◽  
Vol 13 (14) ◽  
pp. 1842-1857 ◽  
Author(s):  
Yohei Shirakami ◽  
Masahito Shimizu ◽  
Hisataka Moriwaki

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