scholarly journals Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Antioxidants ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 26 ◽  
Author(s):  
Valeria Naponelli ◽  
Ileana Ramazzina ◽  
Chiara Lenzi ◽  
Saverio Bettuzzi ◽  
Federica Rizzi
Keyword(s):  
Prostate Cancer ◽  
Cancer Prevention ◽  
Green Tea ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Prostate Cancer Prevention ◽  
Future Challenges

scholarly journals Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

2017 ◽  
Author(s):  
Valeria Naponelli ◽  
Ileana Ramazzina ◽  
Chiara Lenzi ◽  
Saverio Bettuzzi ◽  
Federica Rizzi
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Tea Catechins ◽  
Cellular Targets ◽  
Surface Receptors ◽  
Green Tea Catechins ◽  
Prostate Cancer Prevention ◽  
Future Challenges ◽  
Related Compounds

Green Tea Catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human Prostate Cancer (PCa) chemoprevention.In the last decades many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets including, cell surface receptors, lipid rafts and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentration that cannot be achieved in vivo.Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs bioavailability through still poor understood mechanisms. Recent efforts to develop delivery systems that increase GTCs overall bioavailability, by mean of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.

scholarly journals Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention

2015 ◽  
Vol 8 (10) ◽  
pp. 879-887 ◽  
Author(s):  
Nagi B. Kumar ◽  
Julio Pow-Sang ◽  
Kathleen M. Egan ◽  
Philippe E. Spiess ◽  
Shohreh Dickinson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Prevention ◽  
Green Tea ◽  
Controlled Trial ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Prostate Cancer Prevention

scholarly journals CHEMOPREVENTION OF HUMAN PROSTATE CANCER BY ORAL ADMINISTRATION OF GREEN TEA CATECHINS: A TRANSLATIONAL RESEARCH STORY

2008 ◽  
Vol 65 (1) ◽  
Author(s):  
S Bettuzzi ◽  
F Rizzi
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Cell Transformation ◽  
Treatment Options ◽  
Intraepithelial Neoplasia ◽  
Clinical Progression ◽  
Elderly Men ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Tumour Activity

Clinical progression of Prostate Cancer (CaP) is variable: some tumours are indolent, others rapidly progress. Because, diagnosis is usually in elderly men, CaP is an ideal target for chemoprevention. We showed that Green Tea Catechins (GTC) possess anti-tumour activity, suggesting that it might be beneficial in the early stages of cell transformation. But an experimental confirmation in a real clinical setting was needed. High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) is a pre-invasive stage of CaP for which no treatment options are available until CaP is diagnosed.

scholarly journals Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis

2019 ◽  
Vol 91 (3) ◽  
Author(s):  
Gianpaolo Perletti ◽  
Vittorio Magri ◽  
Anne Vral ◽  
Konstantinos Stamatiou ◽  
Alberto Trinchieri
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Binary Data ◽  
Meta Analysis ◽  
Intraepithelial Neoplasia ◽  
Pooled Analysis ◽  
Protective Role ◽  
Tea Catechins ◽  
Prostate Intraepithelial Neoplasia ◽  
Green Tea Catechins

A focused, single outcome meta-analysis on the protective role of extracts of green tea catechins against prostate cancer. Randomized, placebo-controlled studies enrolling patients with a histologically confirmed diagnosis of high-grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar proliferation but no prostate cancer were included. Meta-analysis for binary data was performed using Mantel-Haenszel statistics, using a random-effects model. Heterogeneity was investigated by calculating the I2. Four studies matched the inclusion criteria for the review. The pooled population was 223 patients; 114 and 109 patients were randomized to catechin and placebo groups, respectively. Nine cases of prstate cancer occurred in the catechin arm (7.9%), and 24 cases were reported in the placebo arm (22%). Pooled analysis resulted in a significant reduction of cancer risk in favor of the catechin arm (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0). In conclusion, our data suggest that the intake of concentrated green tea catechin preparations may confer a significant protective effect to carriers of early neoplastic lesions in the prostate. The quality of the evidence is moderate, and additional, largescale studies are warranted to substantiate these preliminary findings.

Effect of green tea catechins in prostate cancer chemoprevention.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Nagi B. Kumar ◽  
Julio Pow-Sang ◽  
Kathleen Egan ◽  
Philippe E. Spiess ◽  
Shohreh I Dickinson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Cancer Chemoprevention ◽  
Tea Catechins ◽  
Green Tea Catechins

Sustained Release Oral Nanoformulated Green Tea for Prostate Cancer Prevention

2012 ◽  
Author(s):  
Hasan Mukhtar ◽  
Nihal Ahmad ◽  
Vaqar M. Adhami ◽  
Naghma Khan
Keyword(s):  
Prostate Cancer ◽  
Sustained Release ◽  
Cancer Prevention ◽  
Green Tea ◽  
Prostate Cancer Prevention

scholarly journals ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer

2018 ◽  
Vol 11 (11) ◽  
pp. 687-696 ◽  
Author(s):  
J. Athene Lane ◽  
Vanessa Er ◽  
Kerry N.L. Avery ◽  
Jeremy Horwood ◽  
Marie Cantwell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Phase Ii ◽  
Controlled Trial ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Increased Risk
Sign in / Sign up

Export Citation Format

Share Document