scholarly journals Mechanism of Capsaicin-Stimulated Gastric HCO3- Secretion – Comparison with Mucosal Acidification

10.5772/58336 ◽  
2014 ◽  
Author(s):  
Koji Takeuchi ◽  
Eitaro Aihara
Keyword(s):  
Mucosal Acidification

Gastric HCO3− secretion induced by mucosal acidification: Different mechanisms depending on acid concentration

2005 ◽  
Vol 13 (1-3) ◽  
pp. 179-190 ◽  
Author(s):  
Eitaro Aihara ◽  
Masamune Hayashi ◽  
Yoko Sasaki ◽  
Koji Takeuchi
Keyword(s):  
Acid Concentration ◽  
Mucosal Acidification

Acid secretion in isolated guinea pig colon

1987 ◽  
Vol 253 (2) ◽  
pp. G155-G164 ◽  
Author(s):  
Y. Suzuki ◽  
K. Kaneko
Keyword(s):  
Carbonic Anhydrase ◽  
Guinea Pig ◽  
Acid Secretion ◽  
Proximal Part ◽  
Bathing Solution ◽  
Maximal Effect ◽  
Dose Dependency ◽  
Ussing Chambers ◽  
Mucosal Acidification ◽  
Ph Stat

Isolated guinea pig distal colons secreted acid into the mucosal bathing solution at a rate of 1.0-1.5 mumol X cm-2 X h-1 when the preparations were mounted in Ussing chambers and bathed with HCO3(-)-CO2-free solution. The rates of the acidification and alkalinization of the solutions were measured by a pH stat system or calculated from changes in the pH of the solution. The acid secretion was localized in the middle and distal parts of the colon but absent in the proximal part of the colon and the cecum. The mucosal acidification was accompanied by serosal alkalinization, the rate of the latter being approximately 60% of the former. A carbonic anhydrase inhibitor, methazolamide (10(-4) M), reduced both the mucosal acidification and serosal alkalinization rates by a similar magnitude. The mucosal acidification was completely abolished by mucosal K+-free conditions but unaffected by mucosal Na+-free conditions. Ouabain added to the mucosal solution promptly inhibited the acid secretion. Dose dependency of the inhibition conformed to the Michaelis-Menten equation with a half-maximal effect at 4 X 10(-6) M. When the pH of the mucosal solution was reduced to 4.3, the rate of the mucosal acidification remained essentially the same as that at pH = 7.4. Vanadate (10(-4) M) added to both the mucosal and serosal solutions significantly reduced the mucosal acidification rate. These results suggest that CO2 derived from the epithelial metabolism is hydrated by carbonic anhydrase in the cell and released H+ enters the mucosal solution while HCO3- enters the serosal solution. H+ exit across the mucosal membrane may be mediated by H+-ATPase that is sensitive to ouabain.

No Role for Prostacyclin IP Receptors in Duodenal HCO3– Secretion Induced by Mucosal Acidification in Mice – Comparison with Capsaicin-Induced Response

Digestion ◽  
2004 ◽  
Vol 70 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Masato Nakashima ◽  
Masako Aoi ◽  
Eitaro Aihara ◽  
Koji Takeuchi
Keyword(s):  
Induced Response ◽  
Mucosal Acidification

scholarly journals CrossTalk proposal: mucosal acidification drives early progressive lung disease in cystic fibrosis

2018 ◽  
Vol 596 (16) ◽  
pp. 3433-3437 ◽  
Author(s):  
Miriam F. Figueira ◽  
Megan J. Webster ◽  
Robert Tarran
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Mucosal Acidification

Stimulation of sodium transport in toad bladder by acidification of mucosal medium

1964 ◽  
Vol 207 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Alexander Leaf ◽  
Albert Keller ◽  
Eleanor F. Dempsey
Keyword(s):  
Urinary Bladder ◽  
Sodium Transport ◽  
Short Circuit ◽  
Electrical Potential ◽  
Short Circuit Current ◽  
Ph Optimum ◽  
Tissue Ph ◽  
Mucosal Acidification ◽  
Sodium Flux ◽  
Stimulation Of

The short-circuit current, sodium flux, and electrical potential across the isolated urinary bladder of the toad were stimulated by acidification of the medium bathing the mucosal or urinary surface of the bladder. By contrast the transport of chloride, potassium, urea, and water across the bladder was unaffected by similar acidification. The pH optimum for this action was approximately 5.5. The tissue pH, as determined by the distribution of DMO-C14, was not detectably affected by mucosal acidification.

1118 Gender Difference in Duodenal HCO3- Response to Mucosal Acidification: Importance of Up-Regulation of ASIC3 by Estradiol

2012 ◽  
Vol 142 (5) ◽  
pp. S-202-S-203
Author(s):  
Koji Takeuchi ◽  
Yumi Ohashi ◽  
Mika Kohmoto ◽  
Hitomi Oka ◽  
Yusuke Nomura ◽  
...  
Keyword(s):  
Gender Difference ◽  
Mucosal Acidification

927 Role of Carbonic Anhydrase II in the Murine Duodenal Secretory Response to CO2, Secretagogues, and Mucosal Acidification

2008 ◽  
Vol 134 (4) ◽  
pp. A-136
Author(s):  
Markus Sjöblom ◽  
Anurag K. Singh ◽  
Anja Krabbenhöft ◽  
Brigitte Riederer ◽  
Michael P. Manns ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Secretory Response ◽  
Carbonic Anhydrase Ii ◽  
Mucosal Acidification
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