No Role for Prostacyclin IP Receptors in Duodenal HCO3– Secretion Induced by Mucosal Acidification in Mice – Comparison with Capsaicin-Induced Response

Digestion ◽  
2004 ◽  
Vol 70 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Masato Nakashima ◽  
Masako Aoi ◽  
Eitaro Aihara ◽  
Koji Takeuchi
Keyword(s):  
Induced Response ◽  
Mucosal Acidification

Wind Pressure and Wind-Induced Vibration of Heliostat

2008 ◽  
Vol 400-402 ◽  
pp. 935-940 ◽  
Author(s):  
Ying Ge Wang ◽  
Zheng Nong Li ◽  
Bo Gong ◽  
Qiu Sheng Li
Keyword(s):  
Dynamic Response ◽  
Wind Direction ◽  
Wind Load ◽  
Wind Pressure ◽  
Induced Response ◽  
Vertical Angle ◽  
Lateral Direction ◽  
Direction Angle ◽  
Wind Pressures ◽  
Fluctuating Wind

Heliostat is the key part of Solar Tower power station, which requires extremely high accuracy in use. But it’s sensitive to gust because of its light structure, so effect of wind load should be taken into account in design. Since structure of heliostat is unusual and different from common ones, experimental investigation on rigid heliostat model using technology of surface pressure mensuration to test 3-dimensional wind loads in wind tunnel was conducted. The paper illustrates distribution and characteristics of reflector’s mean and fluctuating wind pressure while wind direction angle varied from 0° to 180° and vertical angle varied from 0° to 90°. Moreover, a finite element model was constructed to perform calculation on wind-induced dynamic response. The results show that the wind load power spectral change rulers are influenced by longitudinal wind turbulence and vortex and are related with Strouhal number; the fluctuating wind pressures between face and back mainly appear positive correlation, and the correlation coefficients at longitudinal wind direction are smaller than those at lateral direction; the fluctuating wind pressures preferably agree with Gaussian distribution at smaller vertical angle and wind direction angle. The wind-induced response and its spectrums reveal that: when vertical angle is small, the background responsive values of reflector’s different parts are approximately similar; in addition, multi-phased resonant response occurring at the bottom. With the increase of , airflow separates at the near side and reunites at the other, as produces vortex which enhances dynamic response at the upper part.

scholarly journals Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions

2021 ◽  
pp. 1-17
Author(s):  
Stefan Bernhard ◽  
Stefan Hug ◽  
Alexander Elias Paul Stratmann ◽  
Maike Erber ◽  
Laura Vidoni ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Severe Trauma ◽  
Induced Response ◽  
Neutrophil Granulocytes ◽  
Inflammatory Conditions ◽  
Flow Cytometric ◽  
Time Flow ◽  
Flow Cytometric Measurement ◽  
Detailed Kinetics

A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically used as biomarker of inflammatory processes. However, the effects of IL-8 on cellular key regulators of neutrophil properties such as the intracellular pH (pH<sub>i</sub>) in dependence of ion transport proteins and during inflammation remain to be elucidated. Therefore, we investigated in detail the fundamental changes in pH<sub>i</sub>, cellular shape, and chemotactic activity elicited by IL-8. Using flow cytometric methods, we determined that the IL-8-induced cellular activity was largely dependent on specific ion channels and transporters, such as the sodium-proton exchanger 1 (NHE1) and non-NHE1-dependent sodium flux. Exposing neutrophils in vitro to a proinflammatory micromilieu with N-formyl-Met-Leu-Phe, LPS, or IL-8 resulted in a diminished response regarding the increase in cellular size and pH. The detailed kinetics of the reduced reactivity of the neutrophil granulocytes could be illustrated in a near-real-time flow cytometric measurement. Last, the LPS-mediated impairment of the IL-8-induced response in neutrophils was confirmed in a translational, animal-free human whole blood model. Overall, we provide novel mechanistic insights for the interaction of IL-8 with neutrophil granulocytes and report in detail about its alteration during systemic inflammation.

Wind-induced response of rice under the action of the downwash flow field of a multi-rotor UAV

2021 ◽  
Vol 203 ◽  
pp. 60-69
Author(s):  
Qiang Shi ◽  
Da Liu ◽  
Hanping Mao ◽  
Baoguo Shen ◽  
Meiqing Li
Keyword(s):  
Flow Field ◽  
Induced Response

Wind tunnel tests and dynamic analysis of wind-induced response of a transmission tower on a hill

2021 ◽  
pp. 136943322110339
Author(s):  
Jian Guo ◽  
Changliang Xiao ◽  
Jiantao Li
Keyword(s):  
Wind Tunnel ◽  
Wind Field ◽  
Dynamic Responses ◽  
Interactive Effects ◽  
Induced Response ◽  
Transmission Tower ◽  
Structural Dynamic ◽  
Wind Tunnel Tests ◽  
Hill Slope ◽  
The Hill

A hill with a lattice transmission tower presents complex wind field characteristics. The commonly used computational fluid dynamics (CFD) simulations are difficult to analyze the wind resistance and dynamic responses of the transmission tower due to structural complexity. In this study, wind tunnel tests and numerical simulations are conducted to analyze the wind field of the hill and the dynamic responses of the transmission tower built on it. The hill models with different slopes are investigated by wind tunnel tests to measure the wind field characteristics, such as mean speed and turbulence intensity. The study shows that the existence of a transmission tower reduces the wind speed on the leeward slope significantly but has little effect on the windward slope. To study the dynamic behavior of the transmission tower, a hybrid analysis procedure is used by introducing the measured experimental wind information to the finite element tower model established using ANSYS. The effects of hill slope on the maximum displacement response of the tower are studied. The results show that the maximum value of the response is the largest when the hill slope is 25° compared to those when hill slope is 15° and 35°. The results extend the knowledge concerning wind tunnel tests on hills of different terrain and provide a comprehensive understanding of the interactive effects between the hill and existing transmission tower regarding to the wind field characteristics and structural dynamic responses.

scholarly journals Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 925
Author(s):  
Eva-Maria Faulhaber ◽  
Tina Jost ◽  
Julia Symank ◽  
Julian Scheper ◽  
Felix Bürkel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Side Effects ◽  
Ionizing Radiation ◽  
Cell Lines ◽  
Normal Tissue ◽  
Kinase Inhibitors ◽  
Induced Response ◽  
Tumor Control ◽  
Tumor Cell Death

(1) Kinase inhibitors (KI) targeting components of the DNA damage repair pathway are a promising new type of drug. Combining them with ionizing radiation therapy (IR), which is commonly used for treatment of head and neck tumors, could improve tumor control, but could also increase negative side effects on surrounding normal tissue. (2) The effect of KI of the DDR (ATMi: AZD0156; ATRi: VE-822, dual DNA-PKi/mTORi: CC-115) in combination with IR on HPV-positive and HPV-negative HNSCC and healthy skin cells was analyzed. Cell death and cell cycle arrest were determined using flow cytometry. Additionally, clonogenic survival and migration were analyzed. (3) Studied HNSCC cell lines reacted differently to DDRi. An increase in cell death for all of the malignant cells could be observed when combining IR and KI. Healthy fibroblasts were not affected by simultaneous treatment. Migration was partially impaired. Influence on the cell cycle varied between the cell lines and inhibitors; (4) In conclusion, a combination of DDRi with IR could be feasible for patients with HNSCC. Side effects on healthy cells are expected to be limited to normal radiation-induced response. Formation of metastases could be decreased because cell migration is impaired partially. The treatment outcome for HPV-negative tumors tends to be improved by combined treatment.

Vibration behavior of an overhead conductor under updraft winds

2021 ◽  
pp. 107754632110058
Author(s):  
Qi Zhou ◽  
Liangtao Zhao ◽  
Chong Zheng ◽  
Feng Tu
Keyword(s):  
Induced Response ◽  
Response Analysis ◽  
Response Factor ◽  
Structural Dynamic ◽  
Resonance Response ◽  
Structural Dynamic Characteristics ◽  
Strong Winds ◽  
American Society ◽  
Gust Response Factor ◽  
Gust Response

At present, the wind-induced response analysis of an overhead conductor is mainly based on the action of horizontal normal wind. However, for crossing hillsides or extremely strong winds, such a conductor will bear the action of updraft wind, which will change the geometry of the conductor and make its structural dynamic characteristics nonlinear to some extent. In this work, the in-plane and out-of-plane two-dimensional nonlinear equations were established under the action of self-weight and updraft wind. Furthermore, the improved equations of conductor tension and sag were obtained, and the wind-induced vibration response was further investigated. The results showed that the updraft wind caused the nonlinearity of the tension and sag of the overhead conductor, and the nonlinear geometric change significantly affected its resonance response, which exceeded 25% if the wind speed was 50 m/s. In addition, because the proportion of the resonance response in the total wind-induced response was different, the influence of the wind attack angle calculated using the gust response factor method on the gust response factor was slightly larger than that calculated using the the American society of civil engineers method.

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