scholarly journals Role of Tumour Markers in Diagnosis and Follow up of Colorectal Cancer — Potential for Future Research

10.5772/57514 ◽  
2014 ◽  
Author(s):  
Robert Partyka
Keyword(s):  
Colorectal Cancer ◽  
Tumour Markers ◽  
Future Research

Role of follow-up in management of local recurrences of colorectal cancer

1998 ◽  
Vol 41 (9) ◽  
pp. 1127-1133 ◽  
Author(s):  
Nicola Pietra ◽  
Leopoldo Sarli ◽  
Renato Costi ◽  
Choua Ouchemi ◽  
Mario Grattarola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Local Recurrences

scholarly journals Role of 18F-FDG PET/CT in the Follow-up of Colorectal Cancer

2020 ◽  
Vol 28 (2) ◽  
pp. 119
Author(s):  
Renata Milardovic ◽  
Nermina Beslic ◽  
Amera Sadija ◽  
Sejla Ceric ◽  
Melika Bukvic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Mismatch Repair Protein MSH2 Expression and Prognosis of Colorectal Cancer Patients

2004 ◽  
Vol 19 (3) ◽  
pp. 190-195 ◽  
Author(s):  
C.G. Bernardo ◽  
J.J. Gonzílez ◽  
L. Sanz ◽  
E. Barbón ◽  
J.G. Noval ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Vascular Invasion ◽  
Sporadic Colorectal Cancer ◽  
Repair Protein ◽  
N Stage ◽  
Colorectal Cancer Patients ◽  
Mismatch Repair Protein

Introduction and aims The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer. Patients and methods A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study. All tumors were resected and tumor specimens were evaluated for MSH2 expression. Clinicopathological data and patient survival were correlated with MSH2 staining. Uni- and multivariate analyses were performed. The minimum follow-up period was five years. Results Curative resection was performed in 34 patients (64.9%), 14 of whom subsequently relapsed. At the end of the overall follow-up 25 (51%) patients had died, 21 of cancer-related causes. Twenty-eight patients (57.1%) were negative for MSH2 staining. Only vascular invasion was significantly correlated with MSH2 expression (lower median values; p=0.04). The overall median survival was 47.9 months (95% CI=27–86.6%). Multivariate analysis of variables in relation to survival showed that T stage (p=0.001), N stage (p<0.001) and MSH2 expression (p=0.01) were independent factors for survival. Conclusions Reduced MSH2 expression is frequent in unselected colorectal cancer patients. Only vascular invasion was correlated with MSH2 expression in this study. Survival was related to TN stage and MSH2 staining.

scholarly journals LINC 01436 is Overexpressed in Colorectal Cancer and Promotes Cancer Cell Proliferation by Suppressing the Maturation of Tumor Suppressive miR-466

2021 ◽  
Author(s):  
Hong Li ◽  
Wei Dong ◽  
Jie Hou ◽  
De He
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Precursor Cell ◽  
Cancer Cell Proliferation ◽  
Poor Survival ◽  
Follow Up Study ◽  
Prognostic Analysis

Abstract LINC 01436 (lncRNA) promotes lung and gastric two types of cancers. However, it is unclear that whether this lncRNA also participate in colorectal cancer (CRC). This study was therefore carried out to analyze the role of LINC 01436 in CRC. Expression of LINC 01436 in CRC patient tissues was analyzed by RT-qPCR and follow-up study was performed for prognostic analysis. Correlation between LINC 01436 and mature miR-466 or miR-466 precursor was analyzed by linear regression. Mature miR-466 and miR-466 precursor expression in CRC cells with the overexpression of LINC 01436 was studied by performing RT-qPCR. The proliferation of CRC cells was subjected to CCK-8 assay analysis. LINC 01436 was upregulated in CRC and predicted poor survival. LINC 01436 and mature miR-466 were inversely correlated, but LINC 01436 and miR-466 precursor were not correlated. In CRC cells, LINC 01436 mediated the downregulation of mature miR-466, but not miR-466 precursor. Cell proliferation analysis showed that LINC 01436 overexpression rescued cell proliferation reduced by miR-466. LINC 01436 is overexpressed in CRC and it may promote cancer cell proliferation by suppressing the maturation of miR-466.

MO860NEUTROPHILS /LYMPHOCYTES RATIO: IS THERE ANY RELATION WITH ARTERIOVENOUS FISTULA EARLY FAILURE ON HEMODIALYSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Hanen Abid ◽  
Salma Toumi ◽  
Rania Lahouimel ◽  
Emna Kharrat ◽  
Rimeh Ben Brahim ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Access Point ◽  
Prognostic Indicators ◽  
Future Research ◽  
Early Failure ◽  
The Mean ◽  
Obesity Hypertension ◽  
Stage Renal Disease

Abstract Background and Aims The native arteriovenous fistula (AVF) is the vascular access point for hemodialysis (HD) in end-stage renal disease (ESRD) patients undergoing HD. The challenge in the follow up of any AVF is to reach a correct maturation state and a higher longevity. The neutrophils to lymphocytes ratio (NLR) and the platelets to lymphocytes ratio (PLR) have been reported in many papers to be prognostic indicators for the AVF failure which seems to be associated with high levels of NLR or PLR. This study aimed to evaluate the role of preoperative NLR and PLR in predicting early AVF failure. Method We conducted a retrospective study including 31 patients who are hemodialysis (HD) in our center and who benefited from an AVF confection during 2019 and 2020. The threshold ratios found in the literature from which the risk of AVF early failure is significant are NLR&gt; = 2.5 and PLR&gt; = 150. These values have been considered the references in our work. Results The average age of our patients is 50 years (20-84 years). The sex ratio is equal to 1,38 (18 men and 13 women). 20 patients started HD when they were under 60 years old and 11 patients after the age of 60. We noticed smoking, obesity, hypertension and diabetes respectively in 16%, 45%, 77%, and 32% of our patients. The causal nephropathy is respectively undetermined in 10 cases, interstitial in 7 cases, diabetic in 6 cases, glomerular in 5 cases and vascular in 3 cases. The type of AVF is proximal in 19 cases (61%) and distal in 12 cases (38%). The AVF failure occurred in 19%. The causes of AVF early failure are respectively a thrombosis in 3 cases, a stenosis in 2 cases and non maturing AVF in one case. The mean NLR is 4,47 (1,09 -17). The mean PLR is 193 (80-397). 74% of our patients have a NLR ≥2,5 and 26% less than 2,5. 61% of the patients have a PLR ≥150 and 39% less than 150. All the patients with an AVF failure have a NLR ≥2,5 however only 5 persons have a PLR ≥150. Among the 6 patients with an AVF failure, the AVF is proximal in 5 cases and distal in one case. We divided our population in two groups: group1 patients with an AVF failure (6 patients) and group2 who don’t have an AVF failure (25 patients). Afterwards, we have studied the correlations between these 2 groups with the NLR interval and PLR interval. We didn’t find any significant correlation between the occurrence of AVF failure with the NLR interval (p=0,11) and PLR interval (p=0,22). We tried to find values of NLR and PLR for which we found a correlation with the AVF failure using the ROC curve. The best cut off to predict AVF failure is 3,45 for NLR and 204 for PLR. Conclusion We demonstrate throw this study that a high preoperative NLR and PLR can predict the early AVF less. These data may serve as a foundation to develop future research on the role of anti-inflammatory medications in the prevention of AVF failure think that required a larger series and more prolonged follow up.

scholarly journals The Role of Scheduled Ct Follow-Up in Patients with Curatively Resected Colorectal Cancer

2014 ◽  
Vol 25 ◽  
pp. v104
Author(s):  
Mina Kato ◽  
Hidekazu Yamaura ◽  
Yozo Sato ◽  
Masataka Kashima ◽  
Hiroshi Kawada ◽  
...  
Keyword(s):  
Colorectal Cancer

Colorectal Cancer Model of Health Disparities: Understanding Mortality Differences in Minority Populations

2006 ◽  
Vol 24 (14) ◽  
pp. 2179-2187 ◽  
Author(s):  
Blase N. Polite ◽  
James J. Dignam ◽  
Olufunmilayo I. Olopade
Keyword(s):  
Colorectal Cancer ◽  
African Americans ◽  
Tumor Biology ◽  
Future Research ◽  
Minority Populations ◽  
Stage At Diagnosis ◽  
Cancer Model ◽  
Appropriate Therapy ◽  
Research And Policy

African Americans are more likely to be diagnosed with and die as a result of colorectal cancer than white patients. This review briefly documents these differences and explores the factors that may contribute to advanced stage at diagnosis and reduced survival once African Americans are diagnosed with colorectal cancer. Attention is focused on what is known about the role of socioeconomic status, cancer screening, comorbidities and lifestyle factors, tumor biology and genetics, and the differences in the receipt of and benefit of appropriate therapy. Finally, areas of ongoing and future research and policy initiatives aimed at reducing disparities are discussed.

Postoperative follow-up of patients with colorectal cancer: a combined evaluation of CT scan, colonoscopy and tumour markers

2004 ◽  
Vol 8 (S1) ◽  
pp. s190-s192 ◽  
Author(s):  
A. Ntinas ◽  
N. Zambas ◽  
S. Al Mogrambi ◽  
P. Petras ◽  
E. Chalvatzoulis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Tumour Markers ◽  
Combined Evaluation
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