Role of follow-up in management of local recurrences of colorectal cancer

1998 ◽  
Vol 41 (9) ◽  
pp. 1127-1133 ◽  
Author(s):  
Nicola Pietra ◽  
Leopoldo Sarli ◽  
Renato Costi ◽  
Choua Ouchemi ◽  
Mario Grattarola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Local Recurrences

scholarly journals Ghost cell odontogenic carcinoma: Role of p53 as predictor of progression

2020 ◽  
Vol 10 (1) ◽  
pp. 1675-1678
Author(s):  
Pallavi Srivastava ◽  
Nidhi Anand ◽  
Nuzhat Husain
Keyword(s):  
Distant Metastases ◽  
Proliferation Index ◽  
Ghost Cell ◽  
Ki 67 ◽  
Local Recurrences ◽  
Odontogenic Carcinoma ◽  
Fibular Flap ◽  
Slow Growing

Ghost cell odontogenic carcinoma (GCOC) a rare malignant Odontogenic Carcinoma with an unpredictable behaviour presenting with local recurrences and distant metastases, to best of our knowledge about 38 cases have been reported in the past. This is an additional case of GCOC in a 25-year old female presented with a slow-growing mandibular swelling since 9 months with restricted jaw mobility. The CT scan showed an ill-defined osteodestructive lesion in the mandible. The histological examination confirms the diagnoses as a GCOC. Immunohistochemical examination was performed for Ki-67 proliferation index and p53 a predictor of progression. This case was managed by wide surgical resection of tumor and reconstruction of the defect by free fibular flap. Six months follow- up period shows no signs of recurrence. GCOC is rare Odontogenic Carcinoma with unpredictable behaviour however p53 & Ki67 proliferation index can predict the progression of tumor and help in differentiation from benign precursor lesions as early diagnosis & treatment of GCOC is necessary to prevent local recurrences & distant metastases.

scholarly journals Role of 18F-FDG PET/CT in the Follow-up of Colorectal Cancer

2020 ◽  
Vol 28 (2) ◽  
pp. 119
Author(s):  
Renata Milardovic ◽  
Nermina Beslic ◽  
Amera Sadija ◽  
Sejla Ceric ◽  
Melika Bukvic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Mismatch Repair Protein MSH2 Expression and Prognosis of Colorectal Cancer Patients

2004 ◽  
Vol 19 (3) ◽  
pp. 190-195 ◽  
Author(s):  
C.G. Bernardo ◽  
J.J. Gonzílez ◽  
L. Sanz ◽  
E. Barbón ◽  
J.G. Noval ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Vascular Invasion ◽  
Sporadic Colorectal Cancer ◽  
Repair Protein ◽  
N Stage ◽  
Colorectal Cancer Patients ◽  
Mismatch Repair Protein

Introduction and aims The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer. Patients and methods A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study. All tumors were resected and tumor specimens were evaluated for MSH2 expression. Clinicopathological data and patient survival were correlated with MSH2 staining. Uni- and multivariate analyses were performed. The minimum follow-up period was five years. Results Curative resection was performed in 34 patients (64.9%), 14 of whom subsequently relapsed. At the end of the overall follow-up 25 (51%) patients had died, 21 of cancer-related causes. Twenty-eight patients (57.1%) were negative for MSH2 staining. Only vascular invasion was significantly correlated with MSH2 expression (lower median values; p=0.04). The overall median survival was 47.9 months (95% CI=27–86.6%). Multivariate analysis of variables in relation to survival showed that T stage (p=0.001), N stage (p<0.001) and MSH2 expression (p=0.01) were independent factors for survival. Conclusions Reduced MSH2 expression is frequent in unselected colorectal cancer patients. Only vascular invasion was correlated with MSH2 expression in this study. Survival was related to TN stage and MSH2 staining.

scholarly journals LINC 01436 is Overexpressed in Colorectal Cancer and Promotes Cancer Cell Proliferation by Suppressing the Maturation of Tumor Suppressive miR-466

2021 ◽  
Author(s):  
Hong Li ◽  
Wei Dong ◽  
Jie Hou ◽  
De He
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Precursor Cell ◽  
Cancer Cell Proliferation ◽  
Poor Survival ◽  
Follow Up Study ◽  
Prognostic Analysis

Abstract LINC 01436 (lncRNA) promotes lung and gastric two types of cancers. However, it is unclear that whether this lncRNA also participate in colorectal cancer (CRC). This study was therefore carried out to analyze the role of LINC 01436 in CRC. Expression of LINC 01436 in CRC patient tissues was analyzed by RT-qPCR and follow-up study was performed for prognostic analysis. Correlation between LINC 01436 and mature miR-466 or miR-466 precursor was analyzed by linear regression. Mature miR-466 and miR-466 precursor expression in CRC cells with the overexpression of LINC 01436 was studied by performing RT-qPCR. The proliferation of CRC cells was subjected to CCK-8 assay analysis. LINC 01436 was upregulated in CRC and predicted poor survival. LINC 01436 and mature miR-466 were inversely correlated, but LINC 01436 and miR-466 precursor were not correlated. In CRC cells, LINC 01436 mediated the downregulation of mature miR-466, but not miR-466 precursor. Cell proliferation analysis showed that LINC 01436 overexpression rescued cell proliferation reduced by miR-466. LINC 01436 is overexpressed in CRC and it may promote cancer cell proliferation by suppressing the maturation of miR-466.

scholarly journals The Role of Scheduled Ct Follow-Up in Patients with Curatively Resected Colorectal Cancer

2014 ◽  
Vol 25 ◽  
pp. v104
Author(s):  
Mina Kato ◽  
Hidekazu Yamaura ◽  
Yozo Sato ◽  
Masataka Kashima ◽  
Hiroshi Kawada ◽  
...  
Keyword(s):  
Colorectal Cancer

scholarly journals Cytoplasmic Expression of DCLK1-S, a Novel DCLK1 Isoform, Is Associated with Tumor Aggressiveness and Worse Disease-Specific Survival in Colorectal Cancer

2021 ◽  
Author(s):  
Elham Kalantari ◽  
Roya Ghods ◽  
Leili Saeednejad Zanjani ◽  
Mandana Rahimi ◽  
Leila Eini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rank Test ◽  
Disease Specific Survival ◽  
Tumor Aggressiveness ◽  
Cytoplasmic Expression ◽  
Normal Tissues ◽  
Log Rank Test ◽  
Disease Specific

Abstract Isoform-specific function of doublecortin-like kinase 1(DCLK1) has highlighted key role of the DCLK1-S (short isoform) in maintenance, progression, and invasion of tumor. Therefore, this study was designed to produce an anti-DCLK1-S polyclonal antibody in order to specifically evaluate expression pattern and clinical significance of DCLK1-S in a well-defined tissue microarray (TMA) series of colorectal tissues including 348 colorectal cancer (CRC) and 51 adjacent normal tissues during a follow-up period of 108 months. Expression of DCLK1-S was significantly higher in CRC samples compared to adjacent normal samples (P < 0.001). Cytoplasmic expression of DCLK1-S was significantly higher in the tumors at advanced stage of the cancer and with poorer differentiation (P<0.001, P= 0.02). The patients with CRC whose tumors showed higher cytoplasmic expression of DCLK1-S had worse disease-specific survival (DSS) (log-rank test, P = 0.03) and 5-year DSS rates (P= 0.01). Additionally, an improved prognostic value was observed in the patients with CRC with high DCLK1-S expression vs. its moderate expression (HR: 2.70, 95% CI: 0.98-7.38; p =0.04) by multivariate analysis. Our findings strongly supported that high cytoplasmic expression of DCLK1-S compared to its moderate expression could be considered as an independent prognostic factor influencing DSS. Taken together, DCLK1-S can be a promising prognostic candidate and targeted-therapeutic indicator for effective treatment of CRC.

scholarly journals Routine Follow-up by Magnetic Resonance Imaging Does Not Improve Detection of Resectable Local Recurrences From Colorectal Cancer

2006 ◽  
Vol 243 (3) ◽  
pp. 348-352 ◽  
Author(s):  
Liviu V. Titu ◽  
Anthony A. Nicholson ◽  
John E. Hartley ◽  
David J. Breen ◽  
John R. T. Monson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Colorectal Cancer ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Local Recurrences
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