scholarly journals Potential Therapeutic Strategies to Prevent the Progression of Alzheimer to Disease States

10.5772/54783 ◽  
2013 ◽  
Author(s):  
Ester Aso ◽  
Isidre Ferrer
Keyword(s):  
Therapeutic Strategies ◽  
Disease States

scholarly journals Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies

Cells ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 50 ◽  
Author(s):  
Tilman Ziegler ◽  
Farah Abdel Rahman ◽  
Victoria Jurisch ◽  
Christian Kupatt
Keyword(s):  
Vessel Wall ◽  
Prolonged Exposure ◽  
Vascular System ◽  
Therapeutic Strategies ◽  
Atherosclerotic Plaques ◽  
Pathological Changes ◽  
Vessel Disease ◽  
Disease States ◽  
Disease Entities ◽  
Key Drivers

Atherosclerosis and associated ischemic organ dysfunction represent the number one cause of mortality worldwide. While the key drivers of atherosclerosis, arterial hypertension, hypercholesterolemia and diabetes mellitus, are well known disease entities and their contribution to the formation of atherosclerotic plaques are intensively studied and well understood, less effort is put on the effect of these disease states on microvascular structure an integrity. In this review we summarize the pathological changes occurring in the vascular system in response to prolonged exposure to these major risk factors, with a particular focus on the differences between these pathological alterations of the vessel wall in larger arteries as compared to the microcirculation. Furthermore, we intend to highlight potential therapeutic strategies to improve microvascular function during atherosclerotic vessel disease.

scholarly journals Clot Structure and Implications for Bleeding and Thrombosis

2019 ◽  
Vol 46 (01) ◽  
pp. 096-104 ◽  
Author(s):  
Emily Mihalko ◽  
Ashley C. Brown
Keyword(s):  
Wound Healing ◽  
Structural Changes ◽  
Fiber Diameter ◽  
Structural Characteristics ◽  
Critical Role ◽  
Fibrin Clot ◽  
Therapeutic Strategies ◽  
Disease States ◽  
Clot Structure ◽  
Coagulation And Fibrinolysis

AbstractThe formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review.

scholarly journals Identification of Disease Risk DNA Variations is Shaping the Future of Precision Health

Genes ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 450
Author(s):  
Walid D. Fakhouri ◽  
Ariadne Letra
Keyword(s):  
Developmental Disorders ◽  
Disease Risk ◽  
Genetic Research ◽  
Therapeutic Strategies ◽  
Special Issue ◽  
Disease States ◽  
Genomic Architecture ◽  
Dna Variations ◽  
Precision Health ◽  
Over Time

In recent years, the knowledge generated by decoding the human genome has allowed groundbreaking genetic research to better understand genomic architecture and heritability in healthy and disease states. The vast amount of data generated over time and yet to be generated provides the basis for translational research towards the development of preventive and therapeutic strategies for many conditions. In this special issue, we highlight the discoveries of disease-associated and protective DNA variations in common human diseases and developmental disorders.

Effects of curcumin in experimental diabetic nephropathy

2016 ◽  
Vol 65 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sharma S Prabhakar
Keyword(s):  
Diabetic Nephropathy ◽  
End Stage Renal Disease ◽  
Complementary Therapies ◽  
Clinical Evidence ◽  
Therapeutic Strategies ◽  
Disease States ◽  
The World ◽  
Health And Disease ◽  
Stage Renal Disease ◽  
End Stage

Diabetic nephropathy (DN) is currently well established as the most common cause of end-stage renal disease in most parts of the world. Notwithstanding the expanding basic and clinical research in this field, the pathogenesis remains far from clear and hence the treatment of DN remains suboptimal. There is a critical need for the development of newer therapeutic strategies including alternative and complementary therapies. One of the natural products that was extensively studied in cancer and other chronic disease states such as diabetes is curcumin, an active ingredient in turmeric, a spice extensively used in India. In this manuscript, we present a critical review of the experimental and clinical evidence that supports the use of curcumin and its analogs in DN as well as the various proposed mechanisms for its biological actions in health and disease states.

scholarly journals Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1350 ◽  
Author(s):  
Rui Rodrigues ◽  
Diogo Lourenço ◽  
Sara Paulo ◽  
Joana Mateus ◽  
Miguel Ferreira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Treatment Options ◽  
Therapeutic Strategies ◽  
Pharmacological Agents ◽  
Social Burden ◽  
Disease States ◽  
Regenerative Therapies

With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology.

DNA nick end labeling: a reliable marker for apoptosis?

1995 ◽  
Vol 53 ◽  
pp. 962-963
Author(s):  
Anne F. Bushnell ◽  
Sarah Webster ◽  
Lynn S. Perlmutter
Keyword(s):  
Cell Death ◽  
Cultured Cells ◽  
Apoptotic Cell ◽  
Morphological Characteristics ◽  
Detection Methods ◽  
Tissue Preparation ◽  
Preparation Methods ◽  
Dna Laddering ◽  
Disease States ◽  
Reliable Marker

Apoptosis, or programmed cell death, is an important mechanism in development and in diverse disease states. The morphological characteristics of apoptosis were first identified using the electron microscope. Since then, DNA laddering on agarose gels was found to correlate well with apoptotic cell death in cultured cells of dissimilar origins. Recently numerous DNA nick end labeling methods have been developed in an attempt to visualize, at the light microscopic level, the apoptotic cells responsible for DNA laddering.The present studies were designed to compare various tissue processing techniques and staining methods to assess the occurrence of apoptosis in post mortem tissue from Alzheimer's diseased (AD) and control human brains by DNA nick end labeling methods. Three tissue preparation methods and two commercial DNA nick end labeling kits were evaluated: the Apoptag kit from Oncor and the Biotin-21 dUTP 3' end labeling kit from Clontech. The detection methods of the two kits differed in that the Oncor kit used digoxigenin dUTP and anti-digoxigenin-peroxidase and the Clontech used biotinylated dUTP and avidinperoxidase. Both used 3-3' diaminobenzidine (DAB) for final color development.

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