scholarly journals Emerging Roles of Atypical Dual Specificity Phosphatases in Cancer

10.5772/54485 ◽  
2013 ◽  
Author(s):  
Erica L. ◽  
Alexander Beeser
Keyword(s):  
Dual Specificity ◽  
Dual Specificity Phosphatases

scholarly journals Structure of human dual-specificity phosphatase 7, a potential cancer drug target

2015 ◽  
Vol 71 (6) ◽  
pp. 650-656 ◽  
Author(s):  
George T. Lountos ◽  
Brian P. Austin ◽  
Joseph E. Tropea ◽  
David S. Waugh
Keyword(s):  
Catalytic Domain ◽  
Three Dimensional ◽  
Mitogen Activated Protein Kinase ◽  
Cancer Drug ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Starting Point ◽  
Mitogen Activated Protein ◽  
Dual Specificity Phosphatases

Human dual-specificity phosphatase 7 (DUSP7/Pyst2) is a 320-residue protein that belongs to the mitogen-activated protein kinase phosphatase (MKP) subfamily of dual-specificity phosphatases. Although its precise biological function is still not fully understood, previous reports have demonstrated that DUSP7 is overexpressed in myeloid leukemia and other malignancies. Therefore, there is interest in developing DUSP7 inhibitors as potential therapeutic agents, especially for cancer. Here, the purification, crystallization and structure determination of the catalytic domain of DUSP7 (Ser141–Ser289/C232S) at 1.67 Å resolution are reported. The structure described here provides a starting point for structure-assisted inhibitor-design efforts and adds to the growing knowledge base of three-dimensional structures of the dual-specificity phosphatase family.

scholarly journals Dual-specificity phosphatases in mental and neurological disorders

2020 ◽  
pp. 101906
Author(s):  
Ning An ◽  
Katherine Bassil ◽  
Ghazi I. Al Jowf ◽  
Harry W.M. Steinbusch ◽  
Markus Rothermel ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Dual Specificity ◽  
Dual Specificity Phosphatases

scholarly journals Regulation of Dual-specificity Phosphatases M3/6 and hVH5 by Phorbol Esters

2000 ◽  
Vol 275 (41) ◽  
pp. 31755-31762 ◽  
Author(s):  
Thomas R. Johnson ◽  
Joseph R. Biggs ◽  
Sarah E. Winbourn ◽  
Andrew S. Kraft
Keyword(s):  
Phorbol Esters ◽  
Dual Specificity ◽  
Dual Specificity Phosphatases

scholarly journals Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability

2019 ◽  
Vol 20 (11) ◽  
pp. 2668 ◽  
Author(s):  
Hsueh-Fen Chen ◽  
Huai-Chia Chuang ◽  
Tse-Hua Tan
Keyword(s):  
Signal Transduction ◽  
Protein Stability ◽  
Protein Kinases ◽  
Post Translational Modifications ◽  
Mitogen Activated Protein Kinases ◽  
Cell Responses ◽  
Dual Specificity ◽  
Duration Magnitude ◽  
Mitogen Activated Protein ◽  
Dual Specificity Phosphatases

Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or spatiotemporal profiles of MAPK activities. Hence, DUSPs need to be properly controlled. Protein post-translational modifications, such as ubiquitination, phosphorylation, methylation, and acetylation, play important roles in the regulation of protein stability and activity. Ubiquitination is critical for controlling protein degradation, activation, and interaction. For DUSPs, ubiquitination induces degradation of eight DUSPs, namely, DUSP1, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, and DUSP16. In addition, protein stability of DUSP2 and DUSP10 is enhanced by phosphorylation. Methylation-induced ubiquitination of DUSP14 stimulates its phosphatase activity. In this review, we summarize the knowledge of the regulation of DUSP stability and ubiquitination through post-translational modifications.

scholarly journals Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function

2019 ◽  
Vol 20 (18) ◽  
pp. 4372 ◽  
Author(s):  
Rafael Pulido ◽  
Roland Lang
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Human Disease ◽  
Molecular Mechanisms ◽  
Biological Function ◽  
Tyrosine Phosphatase ◽  
Heterogeneous Group ◽  
Class I ◽  
Protein Tyrosine ◽  
Dual Specificity ◽  
Dual Specificity Phosphatases

Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of enzymes, relevant in human disease, which belong to the class I Cys-based group of protein tyrosine phosphatase (PTP) gene superfamily [...]

MAP kinase tight binding to dual-specificity phosphatases: A mechanism for enzymatic specificity

1999 ◽  
Vol 27 (3) ◽  
pp. A72-A72
Author(s):  
Montserrat Camps ◽  
Nathalie Bot ◽  
Anthony Nichols ◽  
Marco Muda ◽  
Corine Gillieron ◽  
...  
Keyword(s):  
Map Kinase ◽  
Tight Binding ◽  
Dual Specificity ◽  
Dual Specificity Phosphatases
Sign in / Sign up

Export Citation Format

Share Document