scholarly journals Demographic and Clinical Characteristics of Mucinous Epithelial Ovarian Cancer, and Survival Following a Mucinous Epithelial Ovarian Cancer Diagnosis

10.5772/53740 ◽  
2013 ◽  
Author(s):  
Sherri L. ◽  
Jennifer M. ◽  
Trevor D. ◽  
Rosemary D. ◽  
Amy R. ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Clinical Characteristics

scholarly journals Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis

2020 ◽  
Vol 3 (7) ◽  
pp. e207566
Author(s):  
Lara Paracchini ◽  
Chiara Pesenti ◽  
Martina Delle Marchette ◽  
Luca Beltrame ◽  
Tommaso Bianchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
High Grade ◽  
Papanicolaou Test ◽  
Serous Epithelial Ovarian Cancer

scholarly journals Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Chenlu Liu ◽  
Yanyun Wang ◽  
Huizi Song ◽  
Qin Li ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Therapeutic Target ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Clinical Characteristics ◽  
Chinese Women ◽  
Healthy Individuals ◽  
Potential Therapeutic Target ◽  
Kaplan Meier

Roles of interleukin-31 (IL-31) in the development and progression of human epithelial ovarian cancer are largely unknown. Studies report that the polymorphisms, rs7977932 C>G and rs4758680 C>A in IL-31, affect the expression level of IL-31. In the present study, we examined 412 patients with epithelial ovarian cancer and 428 healthy individuals to explore whether these polymorphisms are associated with the epithelial ovarian cancer in Chinese women. The genotype of the polymorphisms in each individual was identified. The associations of the polymorphisms with patients’ clinical characteristics and outcomes were evaluated. For rs7977932, the frequency of the CG/GG was significantly decreased in patients with epithelial ovarian cancer. However, the frequency of the rs4758680 CA/AA was significantly increased in those patients. Moreover, the frequency of rs7977932 CG/GG genotype was significantly higher in patients with less advanced FIGO stages. Kaplan-Meier curve showed that patients with CG/GG genotypes of rs7977932 had a decreased risk for recurrence compared to those with CC genotype. Our findings suggested that rs7977932 and rs4758680 of IL-31 may be associated with the development and progression of the epithelial ovarian cancer in the Chinese population. IL-31, therefore, may be a potential therapeutic target for the development of drugs to treat the disease.

scholarly journals Serum CA125, CA199 and CEA combined detection for epithelial ovarian cancer diagnosis: A meta-analysis

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Junhong Guo ◽  
Jiangtao Yu ◽  
Xiaojie Song ◽  
Haixia Mi
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Diagnostic Odds Ratio ◽  
Diagnostic Sensitivity ◽  
Serum Ca125 ◽  
Sensitivity Specificity

AbstractObjectiveTo evaluate the diagnostic value of combination detection of serum cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA199) and carci noembryonic antigen(CEA) in patients with epithelial ovarian cancer by pooling the open published studies according to meta-analysis method.MethodsDiagnostic studies related to combination detection of serum CA125, CA199 and CEA in patients with epithelial ovarian cancer were electronic searched in the databases of PubMed, Cochrane, Google scholar, EMBASE, ISI Web of Knowledge and CNKI by two independent reviewers. The combined diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were pooled by Med DiSc1.4 software.ResultsTwelve prospective diagnostic publications were finally fulfilled the inclusion criteria and were included in this meta-analysis. The pooled diagnostic sensitivity specificity, positive likely hood ratio, negative likely hood ratio, diagnostic odds ratio, and AUC were 0.90 (95%CI: 0.80 to 0.92), 0.83 (95%CI: 0.80 to 0.86), 5.35(95%CI:3.90 to 7.33), 0.13 (95%CI: 0.10 to 0.16), 48.53 (95%CI: 29.91 to 78.72) and 0.92 (95%C: 0.89 to 0.94) respectively by fixed or random effect model. No publication bias was found according to the funnel plot and line regression test (t=-1.34, P=0.21).ConclusionCombination detection serum CA125, CA199 and CEA was a promising biomarker forepithelial ovarian cancer diagnosis with relative high sensitivity and specificity.

scholarly journals A predictive model for serous epithelial ovarian cancer chemo-response using clinical characteristics

2018 ◽  
Vol 8 (1) ◽  
pp. 1-2
Author(s):  
Andreea Mihai Newtson ◽  
Rebecca K Chung ◽  
Eric J Devor ◽  
Erin A Salinas ◽  
Megan E McDonald ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Predictive Model ◽  
Clinical Characteristics ◽  
Serous Epithelial Ovarian Cancer
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