ROMA or death: advances in epithelial ovarian cancer diagnosis

2011 ◽  
Vol 49 (3) ◽  
Author(s):  
Mario Plebani ◽  
Bohuslav Melichar
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis

scholarly journals Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis

2020 ◽  
Vol 3 (7) ◽  
pp. e207566
Author(s):  
Lara Paracchini ◽  
Chiara Pesenti ◽  
Martina Delle Marchette ◽  
Luca Beltrame ◽  
Tommaso Bianchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
High Grade ◽  
Papanicolaou Test ◽  
Serous Epithelial Ovarian Cancer

scholarly journals Serum CA125, CA199 and CEA combined detection for epithelial ovarian cancer diagnosis: A meta-analysis

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Junhong Guo ◽  
Jiangtao Yu ◽  
Xiaojie Song ◽  
Haixia Mi
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Diagnostic Odds Ratio ◽  
Diagnostic Sensitivity ◽  
Serum Ca125 ◽  
Sensitivity Specificity

AbstractObjectiveTo evaluate the diagnostic value of combination detection of serum cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA199) and carci noembryonic antigen(CEA) in patients with epithelial ovarian cancer by pooling the open published studies according to meta-analysis method.MethodsDiagnostic studies related to combination detection of serum CA125, CA199 and CEA in patients with epithelial ovarian cancer were electronic searched in the databases of PubMed, Cochrane, Google scholar, EMBASE, ISI Web of Knowledge and CNKI by two independent reviewers. The combined diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were pooled by Med DiSc1.4 software.ResultsTwelve prospective diagnostic publications were finally fulfilled the inclusion criteria and were included in this meta-analysis. The pooled diagnostic sensitivity specificity, positive likely hood ratio, negative likely hood ratio, diagnostic odds ratio, and AUC were 0.90 (95%CI: 0.80 to 0.92), 0.83 (95%CI: 0.80 to 0.86), 5.35(95%CI:3.90 to 7.33), 0.13 (95%CI: 0.10 to 0.16), 48.53 (95%CI: 29.91 to 78.72) and 0.92 (95%C: 0.89 to 0.94) respectively by fixed or random effect model. No publication bias was found according to the funnel plot and line regression test (t=-1.34, P=0.21).ConclusionCombination detection serum CA125, CA199 and CEA was a promising biomarker forepithelial ovarian cancer diagnosis with relative high sensitivity and specificity.

Causes of death among women with epithelial ovarian cancer by length of survival post-diagnosis: a population-based study in British Columbia, Canada

2018 ◽  
Vol 29 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Nimisha Arora ◽  
Aline Talhouk ◽  
Jessica N. McAlpine ◽  
Michael R. Law ◽  
Gillian E. Hanley
Keyword(s):  
Colorectal Cancer ◽  
Ovarian Cancer ◽  
British Columbia ◽  
Cancer Survivors ◽  
Epithelial Ovarian Cancer ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Causes Of Death ◽  
Population Based

ObjectivesLittle is known regarding the health of women who survive more than 5 years following their ovarian cancer diagnosis. To bridge an important gap in our knowledge about long term health of ovarian cancer survivors, we examined the causes of death among women diagnosed with epithelial ovarian cancer between 1990 and 2014 in British Columbia. These causes were stratified by years since diagnosis, and compared with age- standardized causes of death among women who have not been diagnosed with ovarian cancer.MethodsWe examined all women with epithelial ovarian cancer in British Columbia 1990–2014 using population- based administrative datasets. We stratified women into three groups: all epithelial ovarian cancer patients; women surviving 5 to 9 years post-diagnosis, and women surviving 10 or more years since diagnosis. All- cause and cause specific standardized mortality ratios (SMRs) were calculated.ResultsThere were 4246 deaths among 6427 women with epithelial ovarian cancer. About 55.9% of deaths were from ovarian cancer. When compared with the general population, the highest SMRs (SMR of 5 or higher) were for deaths from other cancers and external causes (44.4% from falls) among women surviving 5–9 years and 10 or more years post-diagnosis. Mortality from other cancers can largely be explained by deaths from breast cancer (15.8%), lung cancer (12.3%), and colorectal cancer (11%).ConclusionsWhile the majority of epithelial ovarian cancer patients continue to die from their ovarian cancer, our results suggest that long term ovarian cancer survivors are particularly vulnerable to deaths from other cancers and from falls in elderly survivors. These data could indicate closer surveillance for breast, lung, and colorectal cancer, and closer attention to bone health is warranted among women surviving for 5 or more years following their epithelial ovarian cancer diagnosis.

scholarly journals Influence of Reproductive Factors on Mortality after Epithelial Ovarian Cancer Diagnosis

2009 ◽  
Vol 18 (7) ◽  
pp. 2035-2041 ◽  
Author(s):  
Cheryl L. Robbins ◽  
Maura K. Whiteman ◽  
Susan D. Hillis ◽  
Kathryn M. Curtis ◽  
Jill A. McDonald ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Diagnosis ◽  
Reproductive Factors

Impact of extended cycles of chemotherapy on survival outcome in recurrent epithelial ovarian cancer

2020 ◽  
Vol 159 ◽  
pp. 346-347
Author(s):  
W.Y. Hwang ◽  
S.I. Kim ◽  
M. Lee ◽  
K. Kim ◽  
J.H. No ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Survival Outcome
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