scholarly journals Heart Diseases in Down Syndrome

Down Syndrome ◽  
10.5772/52285 ◽  
2013 ◽  
Author(s):  
A. K. M. Mamunur Rashid
Keyword(s):  
Down Syndrome ◽  
Heart Diseases

scholarly journals Prevalence and profile of congenital heart disease and pulmonary hypertension in Down syndrome in a pediatric cardiology service

2014 ◽  
Vol 32 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Felipe Alves Mourato ◽  
Lúcia Roberta R. Villachan ◽  
Sandra da Silva Mattos
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Down Syndrome ◽  
Heart Disease ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Heart Defects ◽  
Descriptive Analysis ◽  
Atrioventricular Septal Defect

OBJECTIVE:To determine the frequence and profile of congenital heart defects in Down syndrome patients referred to a pediatric cardiologic center, considering the age of referral, gender, type of heart disease diagnosed by transthoracic echocardiography and its association with pulmonary hypertension at the initial diagnosis.METHODS:Cross-sectional study with retrospective data collection of 138 patients with Down syndrome from a total of 17,873 records. Descriptive analysis of the data was performed, using Epi-Info version 7.RESULTS: Among the 138 patients with Down syndrome, females prevailed (56.1%) and 112 (81.2%) were diagnosed with congenital heart disease. The most common lesion was ostium secundum atrial septal defect, present in 51.8%, followed by atrioventricular septal defect, in 46.4%. Ventricular septal defects were present in 27.7%, while tetralogy of Fallot represented 6.3% of the cases. Other cardiac malformations corresponded to 12.5%. Pulmonary hypertension was associated with 37.5% of the heart diseases. Only 35.5% of the patients were referred before six months of age.CONCLUSIONS: The low percentage of referral until six months of age highlights the need for a better tracking of patients with Down syndrome in the context of congenital heart disease, due to the high frequency and progression of pulmonary hypertension.

scholarly journals Pattern of Congenital Heart Diseases and Treatment Options in a Bangladeshi Centre: Analysis of 6914 cases from Non-invasive Cardiac Laboratory

2017 ◽  
Vol 9 (2) ◽  
pp. 97-105
Author(s):  
Nurun Nahar Fatema
Keyword(s):  
Down Syndrome ◽  
Chromosomal Abnormality ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Ductus Arteriosus ◽  
Treatment Options ◽  
Atrioventricular Septal Defect ◽  
Congenital Heart Diseases ◽  
Transposition Of Great Arteries

Background: Echocardiography is the most sensitive tool to diagnose congenital heart diseases efficiently. It can be repeated as many times as required to see the progress, outcome of treatment and complications. Echocardiography laboratory can give a scenario of pattern of congenital heart diseases existing in Bangladesh as well as natural history of the cases and treatment options offered.Methods: It is a retrospective review of database of echocardiography patient from pediatric noninvasive laboratory of a cardiac hospital from January 2012 to December 2012.Results: Out of 6914 cases 55.73% were male and 44.27% female. Neonates include 8.48%, 36.62% Down Syndrome were infant, 34.02% were under 5 years, 17.97% were children and adolescents and 2.96% were adults. Normal Echocardiography finding was found in 17.28% cases. Ventricular septal defect (VSD) was found in 18.60% cases, Atrial septal defects (ASD) in 15.41% cases, Patent ductus arteriosus (PDA) in 8.59% cases, Atrioventricular septal defect (AVSD) in 1.97% cases, Tetralogy of Fallot (TOF) in 4.79% cases and Transposition of great arteries (TGA) in 2.26% cases. Down syndrome was the commonest chromosomal abnormality seen in 2.4% cases.Conclusion: This study shows that VSD is the commonest congenital heart lesions in our country followed by ASD. Down syndrome was the commonest chromosomal abnormality seen in 2.4% cases.Cardiovasc. j. 2017; 9(2): 97-105

scholarly journals ORAL HYGIENE OF DOWN SYNDROME CHILDREN BORN TO ELDERLY PRIMIGRAVIDA

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Asha Nara ◽  
Imit Pal Saluja ◽  
Sabitha Ramisetty ◽  
Abhishek Sinha ◽  
Rajsekhar. B
Keyword(s):  
Down Syndrome ◽  
Dental Caries ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Heart Diseases ◽  
Past History ◽  
The Elderly ◽  
Reproductive Age ◽  
Obstetric History ◽  
Clinical Presentations

Materials and methods: Prospective study of reproductive age group of female patients in the range of 30-39 years were included in the study who had conceived for the first time -elderly primigravida were obtained from Navodaya hospitals during the period of 2017 to 2019 in Karnataka who had bad obstetric history with high risk of complications of hypertension, fibroids, malpresentation, malposition, prolonged labour, premature labour and perinatal mortality. Few of the elderly primigravida had past history of anaemia, diabetes and heart diseases. Children born to them who were suspected to be suffering from Down syndrome were evaluated genetically. Children suffering from Down syndrome who had bad oral hygiene comprising periodontal disease, dental caries, facial and dental anomalies and other clinical presentations like compromised immune system, hypotonia, seizures were included in the study of age ranging from 01-10 years. Total data obtained for a period of 3years were 108 children of which 62 were boys and remaining girls 46. Periodontal disease was the most common oral health problem in children with Down syndrome born to elderly primigravida with bad obstetric history followed by dental caries. Results: In the genetic evaluation the children who were suffering from Down syndrome found out to be was standard trisomy (83.6%), comparing to translocation1 and mosaicism. Majority of the children presented with periodontal disease were 33 (30.6%), of which 23 boys and remaining girls. Dental caries17 (15.7%), boys presented were 10 and the remaining cases were girls (07). Conclusion: Majority of the Down syndrome children presented with periodontal disease and caries teeth apart from other clinical presentations. Keywords: Elderly primigravida, Down syndrome, bad oral hygiene.

We need to pay special attention on sleep postures and heart diseases in down syndrome with sleep disordered breathing

2013 ◽  
Vol 14 ◽  
pp. e225
Author(s):  
J. Ono ◽  
H. Sawatari ◽  
A. Chishaki ◽  
A. Rahmawati ◽  
H. Kuroda ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Sleep Disordered Breathing ◽  
Heart Diseases ◽  
Disordered Breathing

scholarly journals Congenital Heart Diseases in Down Syndrome Children at Albala Area, Saudi Arabia

2017 ◽  
Vol 03 (02) ◽  
Author(s):  
Almawazini AM ◽  
Ali A Sharkawy ◽  
Osama Mohammed Eldadah ◽  
Yahya Ali Sumaily ◽  
Tarig Yassin Alamery
Keyword(s):  
Saudi Arabia ◽  
Down Syndrome ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases

scholarly journals The spectrum of congenital heart diseases in down syndrome. A retrospective study from Northwest Saudi Arabia

2016 ◽  
Vol 37 (7) ◽  
pp. 767-772 ◽  
Author(s):  
Mohamed Morsy ◽  
Osama Algrigri ◽  
Sherif Salem ◽  
Mostafa Abosedera ◽  
Ashraf Abutaleb ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Down Syndrome ◽  
Retrospective Study ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases

scholarly journals Major birth defects among infants with Down syndrome in Alexandria, Egypt [1995-2000]: trends and risk factors

2001 ◽  
Vol 7 (3) ◽  
pp. 441-451
Author(s):  
M. M. Mokhtar ◽  
M. Abdel Fattah
Keyword(s):  
Down Syndrome ◽  
Contraceptive Use ◽  
Case Control Study ◽  
Heart Diseases ◽  
Multiple Logistic Regression Analysis ◽  
Reproductive Factors ◽  
Oral Contraceptive Use ◽  
Increased Risk ◽  
Antibiotics Use ◽  
Control Study

We evaluated the hypothesis that the trisomy 21 genome interacts with environmental factors during early pregnancy to increase the risk for birth anomalies in Down syndrome infants in Alexandria, Egypt. A case-control study on 514 infants with confirmed Down syndrome was carried out from 1 July 1995 to 30 June 2000. Genetic, biological, environmental and reproductive factors were analysed. Multiple logistic regression analysis showed the following factors to be independently associated with increased risk of congenital heart diseases among Down syndrome patients: parental consanguinity, maternal parents’ consanguinity, mother’s antibiotics use in pregnancy, oral contraceptive use and diabetes in the mother. Fever in the mother during pregnancy was associated with increased risk of gastrointestinal anomalies.

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