scholarly journals Role of Prefrontal Cortex Dopamine and Noradrenaline Circuitry in Addiction

10.5772/51221 ◽  
2012 ◽  
Author(s):  
Ezio Carboni ◽  
Roberto Cadeddu ◽  
Anna Rosa
Keyword(s):  
Prefrontal Cortex

Alcohol Dependence Conceptualized as a Stress Disorder

2019 ◽  
pp. 198-220
Author(s):  
Leandro F. Vendruscolo ◽  
George F. Koob
Keyword(s):  
Prefrontal Cortex ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Glucocorticoid Receptors ◽  
Critical Role ◽  
Emotional States ◽  
Brain Circuits ◽  
Negative Emotional State ◽  
Alcohol Alcohol

Alcohol use disorder is a chronically relapsing disorder that involves (1) compulsivity to seek and take alcohol, (2) difficulty in limiting alcohol intake, and (3) emergence of a negative emotional state (e.g., dysphoria, anxiety, irritability) in the absence of alcohol. Alcohol addiction encompasses a three-stage cycle that becomes more intense as alcohol use progresses: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. These stages engage neuroadaptations in brain circuits that involve the basal ganglia (reward hypofunction), extended amygdala (stress sensitization), and prefrontal cortex (executive function disorder). This chapter discusses key neuroadaptations in the hypothalamic and extrahypothalamic stress systems and the critical role of glucocorticoid receptors. These neuroadaptations contribute to negative emotional states that powerfully drive compulsive alcohol drinking and seeking. These changes in association with a disruption of prefrontal cortex function that lead to cognitive deficits and poor decision making contribute to the chronic relapsing nature of alcohol dependence.

Functional role of dorsolateral prefrontal cortex in the modulation of cognitive bias

2021 ◽  
Author(s):  
Xue Xia ◽  
Yansong Li ◽  
Yanqiu Wang ◽  
Jing Xia ◽  
Yitong Lin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cognitive Bias ◽  
Functional Role ◽  
Dorsolateral Prefrontal Cortex ◽  
Dorsolateral Prefrontal

The role of the left prefrontal cortex in verbal processing

Neuroreport ◽  
1994 ◽  
Vol 5 (16) ◽  
pp. 2193-2196 ◽  
Author(s):  
Shitij Kapur ◽  
Randi Rose ◽  
Peter F. Liddle ◽  
Robert B. Zipursky ◽  
Gregory M. Brown ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Verbal Processing
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