Memory for public events in amnestic mild cognitive impairment: The role of hippocampus and ventro‐medial prefrontal cortex

2021 ◽  
Author(s):  
Laura Serra ◽  
Maria Stefania De simone ◽  
Lucia Fadda ◽  
Roberta Perri ◽  
Carlo Caltagirone ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Mild Cognitive Impairment ◽  
Medial Prefrontal Cortex ◽  
Amnestic Mild Cognitive Impairment ◽  
Public Events

scholarly journals Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Qing Ye ◽  
Haifeng Chen ◽  
Renyuan Liu ◽  
Ruomeng Qin ◽  
Caimei Luo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Medial Prefrontal Cortex ◽  
Memory Deficits ◽  
Amnestic Mild Cognitive Impairment ◽  
Hippocampal Networks ◽  
The Right

Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks.

scholarly journals Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment

NeuroImage ◽  
2012 ◽  
Vol 59 (4) ◽  
pp. 3309-3315 ◽  
Author(s):  
Marine Fouquet ◽  
Béatrice Desgranges ◽  
Renaud La Joie ◽  
Denis Rivière ◽  
Jean-François Mangin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Encoding ◽  
Hippocampal Ca1

P4-263: The role of ApoE-4 in hippocampal hyperactivity in amnestic mild cognitive impairment

2015 ◽  
Vol 11 (7S_Part_19) ◽  
pp. P884-P884
Author(s):  
Arnold Bakker ◽  
Tammy Tran ◽  
Caroline Speck ◽  
Aparna Pisupati ◽  
Michela Gallagher
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment

scholarly journals Sustaining prospective memory functioning in amnestic mild cognitive impairment: A lifespan approach to the critical role of encoding.

2018 ◽  
Vol 32 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Antonina Pereira ◽  
Mareike Altgassen ◽  
Lesley Atchison ◽  
Alexandre de Mendonça ◽  
Judi Ellis
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Critical Role ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Functioning
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