scholarly journals Biomimetic and Electrodeposited Calcium-Phosphates Coatings on Ti - Formation, Surface Characterization, Biological Response

10.5772/48693 ◽  
2012 ◽  
Author(s):  
Marcin Pisarek ◽  
Agata Roguska ◽  
Lionel Marcon ◽  
Mariusz Andrzejczuk
Keyword(s):  
Surface Characterization ◽  
Calcium Phosphates ◽  
Biological Response

Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response

Biomaterials ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 135-150 ◽  
Author(s):  
S Langstaff ◽  
M Sayer ◽  
T.J.N Smith ◽  
S.M Pugh
Keyword(s):  
Calcium Phosphates ◽  
Biological Response

Polydimethylsiloxane/Calcium Phosphates Composites: Effect of the Fillers Modification on the Cross-Linking and Surface Energy

2012 ◽  
Vol 727-728 ◽  
pp. 1175-1180 ◽  
Author(s):  
Oscar F. Bareiro ◽  
Luis Alberto Santos
Keyword(s):  
Surface Energy ◽  
Calcium Phosphates ◽  
High Surface ◽  
High Surface Area ◽  
Biological Response ◽  
Lower Surface ◽  
Cross Linking ◽  
Dimethyl Siloxane ◽  
Static Contact ◽  
Silicone Matrix

A potential approach to achieving the objective of favorably modulating the biological response of implantable biopolymers combined with good mechanical properties is to consider compounding the biopolymer with a bioactive nanocrystalline ceramic biomimetic material with high surface area. In this work, n-HAp (nanohydroxyapatite) and n-α-TCP (nanoα-tricalcium phosphate) powders were modified by silane coupling agent and mixed with poly (dimethyl siloxane) gum so nanocomposites could be achieved. The influence of the introduction of modified and unmodified calcium phosphate particles on the composite thermodynamics parameters of cross-linking, static contact angle and surface energy were investigated. It was found that the dispersion state of modified particles in the silicone matrix was homogeneous. The introduction of fillers into the silicone matrix changed the enthalpy of cross-linking. The addition of unmodified particles led to higher surface energy values, on the other hand, modified particles led to lower surface energy values.

Preparation and Analysis of Ti and Alloyed Ti Surfaces Used in the Evaluation of Biological Response

1987 ◽  
Vol 110 ◽  
Author(s):  
J. Lausmaa ◽  
M. Ask ◽  
U. Rolander ◽  
B. Kasemo
Keyword(s):  
Surface Characterization ◽  
Biological Response ◽  
Anodic Oxide ◽  
Surface Oxide ◽  
Grain Structure ◽  
Two Phase ◽  
Bulk Metal ◽  
Ti Alloys ◽  
Surface Oxides

AbstractThe biocompatibility of Ti and Ti alloys is closely associated with the passivating surface oxide which covers these materials. In this paper results are presented from a broad surface characterization of pure Ti and Ti6A14V alloy surface oxides prepared by thermal oxidation by machining, or by electrochemical procedures (electropolishing and anodic oxidation). The chemical composition of the surface oxide on both materials is mainly TiO2, as shown by XPS, AES, and SIMS analyses. Significant differences exist for both the thermal and anodic oxides, in that the alloying elements are present in the surface oxide of the alloy. TEM and STEM studies show that the microstructure of the anodic oxide films is rather heterogeneous with areas of different porosity which can be correlated with the grain structure of the bulk metals. Oxides on the alloy are even more heterogeneous than on Ti, due to the more complex (two-phase) microstructure of the bulk metal, and also differ in crystallinity. The differences in the surface oxide properties can be expected to lead to differences in the biological response to these two materials. With the alloy, one must consider the risk of Al and/or V dissolution into the biological system.

scholarly journals Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 772 ◽  
Author(s):  
Cristina Busuioc ◽  
Elena Olaret ◽  
Izabela-Cristina Stancu ◽  
Adrian-Ionut Nicoara ◽  
Sorin-Ion Jinga
Keyword(s):  
Barium Titanate ◽  
Calcium Phosphates ◽  
Biological Response ◽  
Heat Treating ◽  
External Stimulation ◽  
Templated Synthesis ◽  
Controlled Morphology ◽  
Barium Titanate Nanoparticles ◽  
Applied Fields ◽  
Tunable Morphology

The current work focuses on the development of mineral scaffolds with complex composition and controlled morphology by using a polymeric template in the form of nonwoven fibre webs fabricated through electrospinning. By a cross-linking process, gelatine fibres stable in aqueous solutions were achieved, these being further subjected to a loading step with two types of mineral phases: calcium phosphates deposited by chemical reaction and barium titanate nanoparticles as decoration on the previously achieved structures. Thus, hybrid materials were obtained and subsequently processed in terms of freeze-drying and heat treating with the purpose of burning the template and consolidating the mineral part as potential bone implants with improved biological response by external stimulation. The results confirmed the tunable morphology, as well as the considerable applicability of both as-prepared and final samples for the development of medical devices, which encourages the continuation of research in the direction of assessing the synergistic contribution of barium titanate domains polarisation/magnetisation by external applied fields.

Tethering Growth Factors to Collagen Surfaces Using Copper-Free Click Chemistry: Surface Characterization and in Vitro Biological Response

2017 ◽  
Vol 9 (28) ◽  
pp. 23389-23399 ◽  
Author(s):  
Hyun Jong Lee ◽  
Gabriella M. Fernandes-Cunha ◽  
Ilham Putra ◽  
Won-Gun Koh ◽  
David Myung
Keyword(s):  
Growth Factors ◽  
Click Chemistry ◽  
Surface Characterization ◽  
Biological Response

Surface Characterization of Hydroxyapatite and Related Calcium Phosphates by XPS and TOF-SIMS

2000 ◽  
Vol 72 (13) ◽  
pp. 2886-2894 ◽  
Author(s):  
Hongbo B. Lu ◽  
Charles T. Campbell ◽  
Daniel J. Graham ◽  
Buddy D. Ratner
Keyword(s):  
Surface Characterization ◽  
Calcium Phosphates ◽  
Tof Sims

Stoichiometry, crystallinity, and nano-scale surface morphology of the graded calcium phosphate-based bio-ceramic interlayer on Ti-Al-V

2002 ◽  
Vol 740 ◽  
Author(s):  
J. D. Long ◽  
K. Ostrikov ◽  
S. Xu ◽  
V. Ligatchev
Keyword(s):  
Surface Morphology ◽  
Surface Characterization ◽  
Calcium Phosphates ◽  
Thick Layer ◽  
Nanocrystalline Structure ◽  
Middle Layer ◽  
Functionally Graded ◽  
Process Conditions ◽  
Nano Scale ◽  
Scale Surface

ABSTRACTA plasma-assisted concurrent Rf sputtering technique for fabrication of biocompatible, functionally graded CaP-based interlayer on Ti-6Al-4V orthopedic alloy is reported. Each layer in the coating is designed to meet a specific functionality. The adherent to the metal layer features elevated content of Ti and supports excellent ceramic-metal interfacial stability. The middle layer features nanocrystalline structure and mimics natural bone apatites. The technique allows one to reproduce Ca/P ratios intrinsic to major natural calcium phosphates. Surface morphology of the outer, a few to few tens of nanometers thick, layer, has been tailored to fit the requirements for the bio-molecule/protein attachment factors. Various material and surface characterization techniques confirm that the optimal surface morphology of the outer layer is achieved for the process conditions yielding nanocrystalline structure of the middle layer. Preliminary cell culturing tests confirm the link between the tailored nano-scale surface morphology, parameters of the middle nanostructured layer, and overall biocompatibility of the coating.

scholarly journals Naturally-Derived Biphasic Calcium Phosphates through Increased Phosphorus-Based Reagent Amounts for Biomedical Applications

Materials ◽  
2019 ◽  
Vol 12 (3) ◽  
pp. 381 ◽  
Author(s):  
Aura-Cătălina Mocanu ◽  
George E. Stan ◽  
Andreea Maidaniuc ◽  
Marian Miculescu ◽  
Iulian Vasile Antoniac ◽  
...  
Keyword(s):  
Chemical Reaction ◽  
Biomedical Applications ◽  
Surface Characterization ◽  
Calcium Phosphates ◽  
Morphological Characterization ◽  
Great Promise ◽  
X Ray Diffraction ◽  
Sem Images ◽  
In Vitro Assessment

Calcium carbonate from marble and seashells is an eco-friendly, sustainable, and largely available bioresource for producing natural bone-like calcium phosphates (CaPs). Based on three main objectives, this research targeted the: (i) adaptation of an indirect synthesis route by modulating the amount of phosphorus used in the chemical reaction, (ii) comprehensive structural, morphological, and surface characterization, and (iii) biocompatibility assessment of the synthesized powdered samples. The morphological characterization was performed on digitally processed scanning electron microscopy (SEM) images. The complementary 3D image augmentation of SEM results also allowed the quantification of roughness parameters. The results revealed that both morphology and roughness were modulated through the induced variation of the synthesis parameters. Structural investigation of the samples was performed by Fourier transform infrared spectroscopy and X-ray diffraction. Depending on the phosphorus amount from the chemical reaction, the structural studies revealed the formation of biphasic CaPs based on hydroxyapatite/brushite or brushite/monetite. The in vitro assessment of the powdered samples demonstrated their capacity to support MC3T3-E1 pre-osteoblast viability and proliferation at comparable levels to the negative cytotoxicity control and the reference material (commercial hydroxyapatite). Therefore, these samples hold great promise for biomedical applications.

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