scholarly journals Spontaneous Diabetes Mellitus in Animals

Author(s):  
Emilia Ciobotaru
1989 ◽  
Vol 2 (2) ◽  
pp. 133-150 ◽  
Author(s):  
Hernan Baquerizo ◽  
John Leone ◽  
Clifford Pukel ◽  
Peter Wood ◽  
Alexander Rabinovitch

Diabetologia ◽  
1995 ◽  
Vol 38 (6) ◽  
pp. 649-655 ◽  
Author(s):  
T. Ishikawa ◽  
Y. Naito ◽  
K. Taniguchi

1990 ◽  
Vol 123 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Wasana Lueprasitsakul ◽  
Susan Abend ◽  
Sharon Alex ◽  
Walter Reinhardt ◽  
Michael C. Appel ◽  
...  

Abstract. Thalidomide, a derivative of glutamic acid, has immunosuppressive effects and suppresses graft-vs-host disease in the rat and following bone marrow transplantation in man. It is effectively used in the treatment of erythema nodosum leprosum and has a potential therapeutic effect in a variety of autoimmune diseases. In view of these observations, we evaluated the effect of thalidomide on the incidence of spontaneous and iodine-induced lymphocytic thyroiditis and spontaneous insulin dependent diabetes mellitus in the BB/Wor rat. Thalidomide did not suppress the incidence of lymphocytic thyroiditis and serum anti-thyroglobulin antibodies or affect the serum concentrations of T4, T3 and TSH in this rat model. Thalidomide also did not affect the incidence of insulin dependent diabetes mellitus. In contrast to preliminary studies in man and rat demonstrating efficacy in the therapy of autoimmune diseases, thalidomide did not prevent or suppress autoimmune lymphocytic thyroiditis or insulin-dependent diabetes mellitus in the BB/Wor rat.


Diabetes ◽  
1982 ◽  
Vol 31 (Supplement_1) ◽  
pp. 26-29 ◽  
Author(s):  
R. L. Engerman ◽  
J. W. Kramer

Diabetes ◽  
1953 ◽  
Vol 2 (4) ◽  
pp. 288-294 ◽  
Author(s):  
H. T. Ricketts ◽  
E. S. Petersen ◽  
P. E. Steiner ◽  
N. Tupikova

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