scholarly journals Spontaneous Diabetes Mellitus in Animals

10.5772/48170 ◽  
2013 ◽  
Author(s):  
Emilia Ciobotaru
Keyword(s):  
Diabetes Mellitus ◽  
Spontaneous Diabetes

Mechanisms of cyclosporine protection against spontaneous diabetes mellitus in the BB/Wor rat

1989 ◽  
Vol 2 (2) ◽  
pp. 133-150 ◽  
Author(s):  
Hernan Baquerizo ◽  
John Leone ◽  
Clifford Pukel ◽  
Peter Wood ◽  
Alexander Rabinovitch
Keyword(s):  
Diabetes Mellitus ◽  
Spontaneous Diabetes

scholarly journals Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus

Diabetologia ◽  
1995 ◽  
Vol 38 (6) ◽  
pp. 649-655 ◽  
Author(s):  
T. Ishikawa ◽  
Y. Naito ◽  
K. Taniguchi
Keyword(s):  
Diabetes Mellitus ◽  
Hearing Impairment ◽  
Spontaneous Diabetes

Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat

1990 ◽  
Vol 123 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Wasana Lueprasitsakul ◽  
Susan Abend ◽  
Sharon Alex ◽  
Walter Reinhardt ◽  
Michael C. Appel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Autoimmune Diseases ◽  
Spontaneous Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Lymphocytic Thyroiditis ◽  
Erythema Nodosum Leprosum ◽  
Graft Vs Host Disease ◽  
Insulin Dependent

Abstract. Thalidomide, a derivative of glutamic acid, has immunosuppressive effects and suppresses graft-vs-host disease in the rat and following bone marrow transplantation in man. It is effectively used in the treatment of erythema nodosum leprosum and has a potential therapeutic effect in a variety of autoimmune diseases. In view of these observations, we evaluated the effect of thalidomide on the incidence of spontaneous and iodine-induced lymphocytic thyroiditis and spontaneous insulin dependent diabetes mellitus in the BB/Wor rat. Thalidomide did not suppress the incidence of lymphocytic thyroiditis and serum anti-thyroglobulin antibodies or affect the serum concentrations of T4, T3 and TSH in this rat model. Thalidomide also did not affect the incidence of insulin dependent diabetes mellitus. In contrast to preliminary studies in man and rat demonstrating efficacy in the therapy of autoimmune diseases, thalidomide did not prevent or suppress autoimmune lymphocytic thyroiditis or insulin-dependent diabetes mellitus in the BB/Wor rat.

Dogs with Induced or Spontaneous Diabetes as Models for the Study of Human Diabetes Mellitus

Diabetes ◽  
1982 ◽  
Vol 31 (Supplement_1) ◽  
pp. 26-29 ◽  
Author(s):  
R. L. Engerman ◽  
J. W. Kramer
Keyword(s):  
Diabetes Mellitus ◽  
Spontaneous Diabetes ◽  
Human Diabetes

Spontaneous Diabetes Mellitus in the Dog: An Account of Eight Cases

Diabetes ◽  
1953 ◽  
Vol 2 (4) ◽  
pp. 288-294 ◽  
Author(s):  
H. T. Ricketts ◽  
E. S. Petersen ◽  
P. E. Steiner ◽  
N. Tupikova
Keyword(s):  
Diabetes Mellitus ◽  
Spontaneous Diabetes
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