scholarly journals Immune Complex Deposits as a Characteristic Feature of Mercury-Induced SLE-Like Autoimmune Process in Inbred and Outbred Mice

10.5772/47734 ◽  
2012 ◽  
Author(s):  
Alla Arefieva ◽  
Marina Krasilshchikova ◽  
Olga Zatsepi
Keyword(s):  
Characteristic Feature ◽  
Immune Complex ◽  
Autoimmune Process ◽  
Outbred Mice

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

Ultrastructural study of cytoskeletal interactions with endosomes in macrophages by quickfreezing and deep-etching method

1990 ◽  
Vol 48 (3) ◽  
pp. 576-577
Author(s):  
Takeshi Baba ◽  
Nobuki Shiozawa ◽  
Masao Hotch ◽  
Shinichi Ohno
Keyword(s):  
Immune Complex ◽  
Ultrastructural Study ◽  
Fc Receptor ◽  
Coated Pits ◽  
Deep Etching ◽  
Receptor Mediated Endocytosis ◽  
Etching Method ◽  
Quick Freezing

Endosomes are vesicular or tubular organelles that play important roles in transports of receptors and receptor―bound ligands during receptor-mediated endocytosis. The mechanisms of endocytic transports from clathrin-coated pits to lysosomes have been studied by many investigators. However, few studies were reported about the interactions between endosomes and cytoskeletons. In this study, Fc-receptor-mediated endocytosis in macrophages are investigated by quick-freezing and deep-etching (QF-DE) method combined with gold-labeled immune complex and “replica scraping method”.

Localization of Immune Complexes in the Basement Membrane of the Ductuli Efferentes of the Rhesus Monkey

1980 ◽  
Vol 38 ◽  
pp. 456-457
Author(s):  
D. Marsh
Keyword(s):  
Basement Membrane ◽  
Fluorescence Microscopy ◽  
Rhesus Monkey ◽  
Immune Complex ◽  
Immune Complexes ◽  
Vas Deferens ◽  
Frozen Sections ◽  
Efferent Ducts ◽  
Complex Deposition ◽  
Sperm Antibodies

As a result of vasectomy, spermatozoa are confined to the epididymis and vas deferens, where they degenerate, releasing antigens that enter the circulation or are engulfed by macrophages. Multiple antigens of the sperm can elicit production of autoantibodies; circulating anti-sperm antibodies are found in a large percentage of vasectomized men, indicating the immunogenicity of the sperm. The increased prevalence of macrophages in the liomen of the rhesus monkey testicular efferent ducts after vasectomy led to further study of this region. Frozen sections were used for evaluation of immunopathological status by fluorescence microscopy with fluorescein-conjugated antibody. Subsequent granular deposits of immune complexes were revealed by positive immunofluorescence staining for complement. The immune complex deposition in the basement membrane surrounding the efferent ducts implies that this region is involved in antigen leakage (Fig. 1).

478-P: Accelerating Atherosclerosis by Autoimmune Process in Nonobese Diabetic Mice Made ApoE Deficient by CRISPR/Cas9 Gene Editing

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 478-P
Author(s):  
KYOUNGMIN PARK ◽  
QIAN LI ◽  
HAIYAN WANG ◽  
RONALD ST-LOUIS ◽  
HISASHI YOKOMIZO ◽  
...  
Keyword(s):  
Gene Editing ◽  
Diabetic Mice ◽  
Autoimmune Process ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Syntaxonomic survey of tundra belt mires of Khibiny mountains (Murmansk Region)

2001 ◽  
pp. 49-57 ◽  
Author(s):  
N. E. Koroleva
Keyword(s):  
Characteristic Feature ◽  
Murmansk Region

The paper deals with syntaxonomy of mountain mires in the lower oroarctic zone of Khibiny Mountains (Mur­mansk Re­gion). Six associations and one subassociation which belong to four alliances are described. Short characte­ristic of syntaxa and phytocoenological tables are given. Prevalence of mesophytic and hygro-meso­phytic species rather than true helophytic species is reported as a characteristic feature of these communities.

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