scholarly journals Cholesterol-Binding Peptides and Phagocytosis

10.5772/38255 ◽  
2012 ◽  
Author(s):  
Antonina Dunina-Barkovskaya
Keyword(s):  
Binding Peptides ◽  
Cholesterol Binding

Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo

Blood ◽  
2004 ◽  
Vol 103 (4) ◽  
pp. 1356-1363 ◽  
Author(s):  
Barbara P. Schick ◽  
David Maslow ◽  
Adrianna Moshinski ◽  
James D. San Antonio
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Tandem Repeats ◽  
Factor Xa ◽  
Low Molecular Weight ◽  
Heparin Binding ◽  
High Affinity ◽  
Binding Peptides

Abstract Patients given unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) for prophylaxis or treatment of thrombosis sometimes suffer serious bleeding. We showed previously that peptides containing 3 or more tandem repeats of heparin-binding consensus sequences have high affinity for LMWH and neutralize LMWH (enoxaparin) in vivo in rats and in vitro in citrate. We have now modified the (ARKKAAKA)n tandem repeat peptides by cyclization or by inclusion of hydrophobic tails or cysteines to promote multimerization. These peptides exhibit high-affinity binding to LMWH (dissociation constant [Kd], ≈ 50 nM), similar potencies in neutralizing anti–Factor Xa activity of UFH and enoxaparin added to normal plasma in vitro, and efficacy equivalent to or greater than protamine. Peptide (ARKKAAKA)3VLVLVLVL was most effective in all plasmas from enoxaparin-treated patients, and was 4- to 20-fold more effective than protamine. Several other peptide structures were effective in some patients' plasmas. All high-affinity peptides reversed inhibition of thrombin-induced clot formation by UFH. These peptides (1 mg/300 g rat) neutralized 1 U/mL anti–Factor Xa activity of enoxaparin in rats within 1 to 2 minutes. Direct blood pressure and heart rate measurements showed little or no hemodynamic effect. These heparin-binding peptides, singly or in combination, are potential candidates for clinical reversal of UFH and LMWH in humans.

Intracellular mineralization of gold nanoparticles using gold ion-binding peptides with cell-penetrating ability

2021 ◽  
Author(s):  
Makoto Ozaki ◽  
Shuhei Yoshida ◽  
Takaaki Tsuruoka ◽  
Kenji Usui
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanostructures ◽  
Ion Binding ◽  
Cell Penetrating ◽  
Binding Peptides ◽  
Conventional Methods ◽  
Gold Ion

Our method can produce uniquely shaped gold nanostructures in lower HAuCl4 concentration than conventional methods by intracellular functions using peptide assembled structures as a template.

In Silico Discovery and Validation of Neuropeptide-Y-Binding Peptides for Sensors

2019 ◽  
Vol 124 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Xingqing Xiao ◽  
Zhifeng Kuang ◽  
B. J. Burke ◽  
Yaroslav Chushak ◽  
Barry L. Farmer ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
In Silico ◽  
Binding Peptides

scholarly journals Metallothionein-like peptides involved in sequestration of Zn in the Zn-accumulating ectomycorrhizal fungus Russula atropurpurea

Metallomics ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. 1693-1701 ◽  
Author(s):  
Tereza Leonhardt ◽  
Jan Sácký ◽  
Pavel Šimek ◽  
Jiří Šantrůček ◽  
Pavel Kotrba
Keyword(s):  
Ectomycorrhizal Fungi ◽  
Ectomycorrhizal Fungus ◽  
Substantial Portion ◽  
Natural Conditions ◽  
Binding Peptides ◽  
Russula Atropurpurea

The first evidence of the existence of gene-encoded Zn-binding peptides that sequester a substantial portion of intracellular Zn in ectomycorrhizal fungi under natural conditions.

Solution Study of Engineered Quartz Binding Peptides Using Replica Exchange Molecular Dynamics

2010 ◽  
Vol 11 (12) ◽  
pp. 3266-3274 ◽  
Author(s):  
Rebecca Notman ◽  
E. Emre Oren ◽  
Candan Tamerler ◽  
Mehmet Sarikaya ◽  
Ram Samudrala ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Replica Exchange ◽  
Replica Exchange Molecular Dynamics ◽  
Solution Study ◽  
Binding Peptides
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