scholarly journals Control and Coordination of Vasomotor Tone in the Microcirculation

10.5772/36721 ◽  
2012 ◽  
Author(s):  
Mauricio A. ◽  
Francisco R. ◽  
Mariela Puebla ◽  
Pablo S. ◽  
Xavier F.
Keyword(s):  
Vasomotor Tone

Baroreflex Sensitivity Assessment – Latest Advances and Strategies

2011 ◽  
Vol 7 (2) ◽  
pp. 89 ◽  
Author(s):  
Maria Teresa La Rovere ◽  
Roberto Maestri ◽  
Gian Domenico Pinna ◽  
◽  
◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Carotid Sinus ◽  
Lower Blood Pressure ◽  
Vasomotor Tone ◽  
Sensitivity Assessment ◽  
Lower Blood ◽  
Prognostic Implications ◽  
Novel Therapeutic Strategies ◽  
Sympathetic Vasomotor Tone ◽  
Stimulation Of

The baroreflex mechanism has been recognised as a key part of cardiovascular regulation. Alterations in the baroreceptor-heart rate reflex (baroreflex sensitivity [BRS]) contribute to sympathetic–parasympathetic imbalance, playing a major role in the development and progression of many cardiovascular disorders. Therefore, the measurement of the baroreflex is a source of valuable information in the clinical management of cardiac disease patients. This article reviews the most relevant advances for the measurement of BRS and their clinical and prognostic implications. Novel therapeutic strategies, exploring the use of electrical stimulation of the carotid sinus, have been evaluated recently in experimental and preliminary clinical studies to lower blood pressure and to reduce the level of baroreflex-mediated sympathoexcitation in heart failure. A recent study has also shown that the implementation of an artificial baroreflex system to regulate sympathetic vasomotor tone automatically is feasible.

scholarly journals Unique Aspects of the Developing Lung Circulation: Structural Development and Regulation of Vasomotor Tone

2016 ◽  
Vol 6 (4) ◽  
pp. 407-425 ◽  
Author(s):  
Yuangsheng Gao ◽  
David N. Cornfield ◽  
Kurt R. Stenmark ◽  
Bernard Thébaud ◽  
Steven H. Abman ◽  
...  
Keyword(s):  
Lung Development ◽  
Lung Diseases ◽  
Vascular Tone ◽  
Current Knowledge ◽  
Normal Lung ◽  
Pulmonary Vasculature ◽  
Structural Development ◽  
Vasomotor Tone ◽  
Disease States ◽  
Vasculogenesis And Angiogenesis

This review summarizes our current knowledge on lung vasculogenesis and angiogenesis during normal lung development and the regulation of fetal and postnatal pulmonary vascular tone. In comparison to that of the adult, the pulmonary circulation of the fetus and newborn displays many unique characteristics. Moreover, altered development of pulmonary vasculature plays a more prominent role in compromised pulmonary vasoreactivity than in the adult. Clinically, a better understanding of the developmental changes in pulmonary vasculature and vasomotor tone and the mechanisms that are disrupted in disease states can lead to the development of new therapies for lung diseases characterized by impaired alveolar structure and pulmonary hypertension.

scholarly journals Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bartłomiej Paleczny ◽  
Rafał Seredyński ◽  
Małgorzata Wyciszkiewicz ◽  
Adrianna Nowicka-Czudak ◽  
Wojciech Łopusiewicz ◽  
...  
Keyword(s):  
Plasma Renin ◽  
Older Men ◽  
Individual Performance ◽  
Breath Holding ◽  
Vasomotor Tone ◽  
Younger Men ◽  
The Individual ◽  
Peripheral Chemoreflex ◽  
Sympathetic Vasomotor Tone ◽  
Marathon Performance

AbstractThe aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r =  − 0.53, r = 0.67, respectively) and pre-race BHT (r =  − 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r =  − 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.

scholarly journals Relationships Among Intravascular Volume, Total Body Sodium, Arterial Pressure, and Vasomotor Tone

1961 ◽  
Vol 9 (6) ◽  
pp. 1233-1239 ◽  
Author(s):  
HIDEO TAKAGI ◽  
HARRIET P. DUSTAN ◽  
IRVINE H. PAGE
Keyword(s):  
Arterial Pressure ◽  
Intravascular Volume ◽  
Vasomotor Tone ◽  
Body Sodium ◽  
Total Body

Effects of autonomic disruption and inactivity on venous vascular function

2000 ◽  
Vol 278 (2) ◽  
pp. H515-H520 ◽  
Author(s):  
Jill M. Wecht ◽  
Ronald E. de Meersman ◽  
Joseph P. Weir ◽  
William A. Bauman ◽  
David R. Grimm
Keyword(s):  
Vascular Function ◽  
Vascular System ◽  
Analysis Of Covariance ◽  
Active Group ◽  
Vasomotor Tone ◽  
Venous Compliance ◽  
Venous Capacitance ◽  
Mean Values ◽  
Sedentary Group ◽  
Cord Injury

The effects of autonomic disruption and inactivity were studied on the venous vascular system. Forty-eight subjects, 24 with spinal cord injury (SCI) and 12 sedentary and 12 active able-bodied controls, participated in this study. Peripheral autonomic data were obtained to estimate sympathetic vasomotor control [low-frequency component of systolic blood pressure (LFSBP)]. Vascular parameters were determined using strain-gauge venous occlusion plethysmography: venous capacitance (VC), venous emptying rate (VER), and total venous outflow (VOt). An additional vascular parameter was calculated: venous compliance [(VC/occlusion pressure) × 100]. VC and VOt were significantly different (SCI < sedentary < active). VER adjusted for VC was not different for any group comparison, whereas venous compliance was significantly lower in the SCI group than in the able-bodied groups and in the sedentary group compared with the active group. Regression analysis for the total group revealed a significant relationship between LFSBP and venous compliance ( r = 0.64, P < 0.0001). After controlling for LFSBP through analysis of covariance, we found that mean differences for all venous vascular parameters did not change from unadjusted mean values. Our findings suggest that in subjects with SCI, the loss of sympathetic vasomotor tone contributes more than inactivity to reductions in venous vascular function. Heightened VC, VOt, vasomotor tone, and venous compliance in the active group compared with the sedentary group imply that regular endurance training contributes to optimal venous vascular function and peripheral autonomic integrity.

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