Baroreflex Sensitivity Assessment – Latest Advances and Strategies

2011 ◽  
Vol 7 (2) ◽  
pp. 89 ◽  
Author(s):  
Maria Teresa La Rovere ◽  
Roberto Maestri ◽  
Gian Domenico Pinna ◽  
◽  
◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Carotid Sinus ◽  
Lower Blood Pressure ◽  
Vasomotor Tone ◽  
Sensitivity Assessment ◽  
Lower Blood ◽  
Prognostic Implications ◽  
Novel Therapeutic Strategies ◽  
Sympathetic Vasomotor Tone ◽  
Stimulation Of

The baroreflex mechanism has been recognised as a key part of cardiovascular regulation. Alterations in the baroreceptor-heart rate reflex (baroreflex sensitivity [BRS]) contribute to sympathetic–parasympathetic imbalance, playing a major role in the development and progression of many cardiovascular disorders. Therefore, the measurement of the baroreflex is a source of valuable information in the clinical management of cardiac disease patients. This article reviews the most relevant advances for the measurement of BRS and their clinical and prognostic implications. Novel therapeutic strategies, exploring the use of electrical stimulation of the carotid sinus, have been evaluated recently in experimental and preliminary clinical studies to lower blood pressure and to reduce the level of baroreflex-mediated sympathoexcitation in heart failure. A recent study has also shown that the implementation of an artificial baroreflex system to regulate sympathetic vasomotor tone automatically is feasible.

Baroreflex Sensitivity Assessment—Latest Advances and Strategies

2012 ◽  
Vol 9 (1) ◽  
pp. 22-25
Author(s):  
Maria Teresa La Rovere ◽  
Roberto Maestri ◽  
Gian Domenico Pinna
Keyword(s):  
Baroreflex Sensitivity ◽  
Carotid Sinus ◽  
Lower Blood Pressure ◽  
Vasomotor Tone ◽  
Sensitivity Assessment ◽  
Lower Blood ◽  
Prognostic Implications ◽  
Novel Therapeutic Strategies ◽  
Sympathetic Vasomotor Tone ◽  
Stimulation Of

The baroreflex mechanism has been recognised as a key part of cardiovascular regulation. Alterations in the baroreceptor-heart rate reflex (baroreflex sensitivity [BRS]) contribute to sympathetic–parasympathetic imbalance, playing a major role in the development and progression of many cardiovascular disorders. Therefore, the measurement of the baroreflex is a source of valuable information in the clinical management of cardiac disease patients. This article reviews the most relevant advances for the measurement of BRS and their clinical and prognostic implications. Novel therapeutic strategies, exploring the use of electrical stimulation of the carotid sinus, have been evaluated recently in experimental and preliminary clinical studies to lower blood pressure and to reduce the level of baroreflex-mediated sympathoexcitation in heart failure. A recent study has also shown that the implementation of an artificial baroreflex system to regulate sympathetic vasomotor tone automatically is feasible.

Stimulation of Peripheral Dopamine Receptors in Rats: A Mechanism for Novel Antihypertensive Agents

1980 ◽  
Vol 59 (s6) ◽  
pp. 291s-294s ◽  
Author(s):  
Francloise Lefegvre-Borg ◽  
Icilio Cavero
Keyword(s):  
Blood Pressure ◽  
Dopamine Receptors ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Agents ◽  
Sympathetic Ganglia ◽  
Vasomotor Tone ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sympathetic Vasomotor Tone ◽  
Stimulation Of

1. The aim of this investigation was to provide support for the hypothesis that stimulation of peripheral dopamine receptors reduces sympathetic vasomotor tone and thus may be a mechanism for novel antihypertensive agents. 2. NN-Di-n-propyldopamine (DPDA: 0.03-0.1 mg min−1 kg−1 intra-arterially) produced sustained decreases in blood pressure measured from the cannulated tail artery in conscious spontaneously hypertensive rats. 3. This antihypertensive action of DPDA was antagonized by sulpiride but not by atropine, promethazine, propranolol or indomethacin. 4. DPDA failed to lower blood pressure in spontaneously hypertensive rats in which peripheral stores of catecholamines had been previously depleted with syrosingopine. 5. In the pithed atropine-pretreated spontaneously hypertensive rats in which the low blood pressure was elevated by electrical stimulation of the spinal cord, DPDA produced hypotensive effects which were antagonized by sulpiride. However, DPDA, in contrast to phentolamine, did not modify the blood pressure raised by an infusion of adrenaline. 6. In conclusion, the blood pressure-lowering action of DPDA is due to stimulation of dopamine receptors which decreases noradrenaline release and consequently sympathetic vasomotor tone. These receptors may be located on sympathetic ganglia or sympathetic endings innervating resistance vessels.

scholarly journals Effectiveness of Stimulation of Acupoint KI 1 byArtemisia vulgaris(Moxa) for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaochen Yang ◽  
Xingjiang Xiong ◽  
Guoyan Yang ◽  
Jie Wang
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Randomized Controlled Trials ◽  
Antihypertensive Drugs ◽  
Controlled Trials ◽  
Lower Blood Pressure ◽  
Clinical Trial Registry ◽  
Randomized Controlled ◽  
Lower Blood ◽  
Stimulation Of

Objective. A systematic review of randomized controlled trials has been performed to assess the effectiveness of stimulation of acupoint KI 1 byArtemisia vulgaris(the Japanese name is moxa) to lower blood pressure compared to antihypertensive drugs.Methods and Findings. Articles published from 1980 to August 2013 in databases of CENTRAL, Pubmed, CBM, CNKI, VIP, and online clinical trial registry websites were searched. Studies included were randomized controlled trials (RCTs); moxibustion-type intervention on KI 1 compared with antihypertensive drugs; meta-analysis showed superior effects of moxibustion plus antihypertensive drugs on systolic blood pressure (WMD: −4.91 [−7.54, −2.28];P=0.0003) but no superior effects on diastolic blood pressure (WMD: −6.38 [−17.17, 4.41];P=0.25).Conclusions. Our systematic review of the current literature shows a beneficial effect of using moxibustion interventions on KI 1 to lower blood pressure compared to antihypertensive drugs. However, the results are influenced by the existing differences in design of the current trials.

Electrical stimulation of the carotid sinus lowers arterial pressure and improves heart rate variability in l-NAME hypertensive conscious rats

2020 ◽  
Vol 43 (10) ◽  
pp. 1057-1067 ◽  
Author(s):  
Gean Domingos-Souza ◽  
Fernanda Machado Santos-Almeida ◽  
César Arruda Meschiari ◽  
Nathanne S. Ferreira ◽  
Camila A. Pereira ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Electrical Stimulation ◽  
Arterial Pressure ◽  
Carotid Sinus ◽  
Conscious Rats ◽  
Stimulation Of

scholarly journals Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bartłomiej Paleczny ◽  
Rafał Seredyński ◽  
Małgorzata Wyciszkiewicz ◽  
Adrianna Nowicka-Czudak ◽  
Wojciech Łopusiewicz ◽  
...  
Keyword(s):  
Plasma Renin ◽  
Older Men ◽  
Individual Performance ◽  
Breath Holding ◽  
Vasomotor Tone ◽  
Younger Men ◽  
The Individual ◽  
Peripheral Chemoreflex ◽  
Sympathetic Vasomotor Tone ◽  
Marathon Performance

AbstractThe aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r =  − 0.53, r = 0.67, respectively) and pre-race BHT (r =  − 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r =  − 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.

Supraspinal inhibition of a cutaneous vascular reflex in the cat

1964 ◽  
Vol 207 (2) ◽  
pp. 303-307 ◽  
Author(s):  
B. J. Prout ◽  
J. H. Coote ◽  
C. B. B. Downman
Keyword(s):  
Carotid Sinus ◽  
Spinal Reflexes ◽  
Descending Pathways ◽  
Skin Response ◽  
Reflex Arc ◽  
Vascular Reflex ◽  
Carotid Sinus Nerve Stimulation ◽  
Sympathetic Discharge ◽  
Stimulation Of ◽  
Cerebellar Stimulation

In cats anesthetized with chloralose-urethane mixture, stimulation of an afferent nerve evoked a vasoconstrictor reflex (VCR) and a galvanic skin response (GSR) in the pads of the feet. Stimulation of the ventromedial medullary reticular substance at the level of the obex abolished the VCR and the GSR. VCR could also be reduced by occlusion during prolonged stimulation of another spinal or visceral afferent pathway. Medulla stimulation was effective without itself causing a sympathetic discharge to the paw, showing that inhibition rather than occlusion was operative. Anterior cerebellar stimulation also inhibited the VCR. Carotid sinus nerve stimulation did not abolish the VCR. It is concluded that the effective mechanism includes a bulbospinal inhibitory path projecting on a spinal vasoconstrictor reflex arc. This arrangement is similar to the descending pathways inhibiting other spinal reflexes but the VCR-inhibitory path can be activated independently of them.

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