scholarly journals The Inflammatory Response of Respiratory System to Metal Nanoparticle Exposure and Its Suppression by Redox Active Agent and Cytokine Therapy

10.5772/34158 ◽  
2012 ◽  
Author(s):  
B.P. Nikolaev ◽  
L. Yu. Yakovleva ◽  
V.A. Mikhalev ◽  
Ya.Yu. Marchenko ◽  
M.V. Gepetskaya ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Respiratory System ◽  
Active Agent ◽  
Metal Nanoparticle ◽  
Cytokine Therapy ◽  
Nanoparticle Exposure ◽  
Redox Active

scholarly journals Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres

2019 ◽  
Vol 56 (1) ◽  
pp. 285-290
Author(s):  
Bianca Domokos-Hancu ◽  
Milena Adina Man ◽  
Antigona Carmen Trofor ◽  
Carmen Monica Pop ◽  
Cristina Maria Gavrilescu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Bronchoalveolar Lavage ◽  
Glass Fiber ◽  
Respiratory System ◽  
Bronchoalveolar Lavage Fluid ◽  
Glass Fibers ◽  
Lavage Fluid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Weight Variation

Given the structural resemblances between glass fiber and asbestos, it is important to understand the mechanisms through which exposure to glass fibers may affect the respiratory system. To study the effect of glass fiber on rat lung through intratracheal exposure, considering the subject�s weight variation, together with haematological parameters, C-reactive protein (CRP), total number of lymphocytes, and IL8 concentration in bronchoalveolar lavage. We performed an intratracheal instillation study on four groups of 8 randomly selected Wistar rats, by administering 3 different doses of glass fiber. The hematocrit value was an indirect indicator of chronic hypoxemia; leukocytes and the C-reactive protein assessed systemic inflammation, and total number of lymphocytes and IL8 concentration in bronchoalveolar lavage fluid determined the lung�s inflammatory response. Weight variation evaluated in all 8 measurements revealed no statistically significant changes (p=0.768). The decrease in mean blood leukocytes was interpreted in relation with the glass fiber dose, with a statistically significant difference between the study groups (p=0.003). Statistically significant differences were found in the CRP values, with dose correlations (p[0.001). The bronchoalveolar lavage fluid showed increased levels of IL-8 (p[0.05), and decrease of lymphocytes (p[0.001) in correlation with the administered glass fiber dose. The inflammatory response following exposure to glass fibers in rats is correlated with administrated glass fiber dose. The alterations described as a result of intratracheal glass fiber instillation could predict the effects which occupational exposure to glass fiber may produce in humans.

scholarly journals Effects of single dose of dexamethasone on patients with systemic inflammatory response

2006 ◽  
Vol 124 (2) ◽  
pp. 90-95 ◽  
Author(s):  
Domingos Dias Cicarelli ◽  
Fábio Ely Martins Benseñor ◽  
Joaquim Edson Vieira
Keyword(s):  
Single Dose ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Respiratory System ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
Double Blind ◽  
Support Unit ◽  
Postoperative Intensive Care ◽  
Postoperative Intensive Care Unit

CONTEXT AND OBJECTIVE: Systemic inflammatory response syndrome (SIRS) is a very common condition among critically ill patients. SIRS, sepsis, septic shock and multiple organ dysfunction syndrome (MODS) can lead to death. Our aim was to investigate the efficacy of a single dose of dexamethasone for blocking the progression of systemic inflammatory response syndrome. DESIGN AND SETTING: Prospective, randomized, double-blind, single-center study in a postoperative intensive care unit (Surgical Support Unit) at Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo. METHODS: The study involved 29 patients with SIRS. All eligible patients were prospectively randomized to receive either a single dose of 0.2 mg/kg of dexamethasone or placebo, after SIRS was diagnosed. The patients were monitored over a seven-day period using Sequential Organ Failure Assessment score (SOFA). RESULTS: The respiratory system showed an improvement on the first day after dexamethasone was administered, demonstrated by the improved PaO2/FiO2 ratio (p < 0.05). The cardiovascular system of patients requiring vasopressor therapy also improved over the first two days, with a better evolution in the dexamethasone group (p < 0.05). Non-surviving patients presented higher lactate assays than did survivors (p < 0.05) during this period. CONCLUSIONS: Dexamethasone enhanced the effects of vasopressor drugs and evaluation of the respiratory system showed improvements (better PaO2/FiO2 ratio), one day after its administration. Despite these improvements, the single dose of dexamethasone did not block the evolution of SIRS.

scholarly journals Inflammatory Response of Lung Macrophages and Epithelial Cells after Exposure to Redox Active Nanoparticles: Effect of Solubility and Antioxidant Treatment

2014 ◽  
Vol 48 (23) ◽  
pp. 13960-13968 ◽  
Author(s):  
Martin Urner ◽  
Andreas Schlicker ◽  
Birgit Roth Z’graggen ◽  
Alexander Stepuk ◽  
Christa Booy ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Antioxidant Treatment ◽  
Lung Macrophages ◽  
Redox Active ◽  
Active Nanoparticles

scholarly journals The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

2017 ◽  
Vol Volume 12 ◽  
pp. 3617-3636 ◽  
Author(s):  
Zhantao Deng ◽  
Jiewen Jin ◽  
Zhenheng Wang ◽  
Yong Wang ◽  
Qian Gao ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Aseptic Loosening ◽  
Metal Nanoparticle ◽  
Nf Kappa B
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