scholarly journals Role of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs

10.5772/33202 ◽  
2012 ◽  
Author(s):  
Mohammad-Reza Rashidi ◽  
Roghiyeh Pashaei-Asl
Keyword(s):  
Xanthine Oxidase ◽  
Aldehyde Oxidase

scholarly journals The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat

1990 ◽  
Vol 268 (3) ◽  
pp. 579-583 ◽  
Author(s):  
S Shaw ◽  
E Jayatilleke
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Liver Injury ◽  
Xanthine Oxidase ◽  
Aldehyde Oxidase ◽  
Ethanol Metabolism ◽  
Dependent Manner ◽  
Hepatic Lipid ◽  
Hepatic Lipid Peroxidation

Hepatic lipid peroxidation has been implicated in the pathogenesis of alcohol-induced liver injury, but the mechanism(s) by which ethanol metabolism or resultant free radicals initiate lipid peroxidation is not fully defined. The role of the molybdenum-containing enzymes aldehyde oxidase and xanthine oxidase in the generation of such free radicals was investigated by measuring alkane production (lipoperoxidation products) in isolated rat hepatocytes during ethanol metabolism. Inhibition of aldehyde oxidase and xanthine oxidase (by feeding tungstate at 100 mg/day per kg) decreased alkane production (80-95%), whereas allopurinol (20 mg/kg by mouth), a marked inhibitor of xanthine oxidase, inhibited alkane production by only 35-50%. Addition of acetaldehyde (0-100 microM) (in the presence of 50 microM-4-methylpyrazole) increased alkane production in a dose-dependent manner (Km of aldehyde oxidase for acetaldehyde 1 mM); menadione, an inhibitor of aldehyde oxidase, virtually inhibited alkane production. Desferrioxamine (5-10 microM) completely abolished alkane production induced by both ethanol and acetaldehyde, indicating the importance of catalytic iron. Thus free radicals generated during the metabolism of acetaldehyde by aldehyde oxidase may be a fundamental mechanism in the initiation of alcohol-induced liver injury.

scholarly journals The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid.

1982 ◽  
Vol 257 (14) ◽  
pp. 8343-8347
Author(s):  
M J Thomas ◽  
K S Mehl ◽  
W A Pryor
Keyword(s):  
Linoleic Acid ◽  
Xanthine Oxidase

scholarly journals The Role of Molybdenum in Xanthine Oxidase and Related Enzymes

1969 ◽  
Vol 244 (10) ◽  
pp. 2658-2663 ◽  
Author(s):  
M P Coughlan ◽  
K V Rajagopalan ◽  
P Handler
Keyword(s):  
Xanthine Oxidase

scholarly journals Role of Xanthine Oxidase in the Reduction of Resazurin by Raw Milk

1961 ◽  
Vol 44 (3) ◽  
pp. 425-429 ◽  
Author(s):  
J.J.R. Campbell ◽  
Lynette B. Keur
Keyword(s):  
Xanthine Oxidase ◽  
Raw Milk

Biological Role of Xanthine Oxidase and Tetrazolium-Reductase Inhibitor

1973 ◽  
Vol 33 (3) ◽  
pp. 439-445 ◽  
Author(s):  
Rainer Fried ◽  
Lygia W. Fried ◽  
Donald R. Babin
Keyword(s):  
Xanthine Oxidase ◽  
Reductase Inhibitor ◽  
Biological Role
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