scholarly journals Neuropsychology of Bulimia Nervosa: New Findings

10.5772/32866 ◽  
2012 ◽  
Author(s):  
Esteban Jaime Camacho Ruiz ◽  
Mara del Consuelo Escoto Ponce de Len ◽  
Juan Manuel Mancilla Daz ◽  
Karina Franco ◽  
Felipe de Jess Daz Resendiz
Keyword(s):  
Bulimia Nervosa ◽  
New Findings

scholarly journals Subtle Breaks In Attachment: Invisible Trauma And The Emergence Of Bulimia Nervosa

2021 ◽  
Author(s):  
Antonia Saunokonoko ◽  
Michelle Mars ◽  
Werner Sattmann-Frese
Keyword(s):  
Bulimia Nervosa ◽  
Lived Experience ◽  
Physical Violence ◽  
Treatment Options ◽  
Treatment Success ◽  
Behavioural Therapy ◽  
Traumatic Experience ◽  
New Findings ◽  
Starting Point ◽  
Trauma Informed

Abstract Background: It is known that complex traumatic experience contributes to the emergence of bulimia nervosa (BN). Yet cognitive behavioural therapy, with or without medication, remains the western medical model’s treatment of choice, regardless of its poor long-term outcomes. Incidence of BN is rising, whilst treatment success eludes most sufferers. This research set out to dig deep into the lived experience of BN in order to uncover new clues linking BN’s aetiology to treatment options; and the research argues for the adoption of trauma-informed protocols for BN, as these fit more effectively with causation. Taking the previously under-researched, but known-to-be significant father-daughter relationship as its starting point, the research reveals a raft of new findings pointing to the pervasive consequences of subtle attachment trauma in this relationship. In light of this, the research informs a clear recommendation for a trauma-informed treatment approach and provides hope for those living with the condition. Methods: A hermeneutic phenomenological, detail-rich study of women in recovery from BN was carried out. A qualitative study was considered to be in sufficient contrast to existing research approaches as to offer up the greatest possibility of new insights into BN. Results: Subtle attachment failures, present in the father-daughter relationship, strongly contribute to complex traumatic experience and are instrumental in the development of BN. Many of these attachment failures lack the overtly dramatic nature of abuses such as physical violence, yet create powerful pre-conditions for the development of bulimic symptomatology. They are rooted in safety-seeking and survival aspects of the attachment bond, causing confusion in aspects of self-worth and anxiety about belonging. The resulting uncertain search for secure nurturing is directly reflected in the push-pull dynamic of the binge/compensation cycle of BN. Conclusions: BN arises in response to complex traumatic experience as a survival mechanism aimed at ensuring psychological and physical protection. Complex traumatic experience is, however, a multi-faceted concept in which subtle breaks in father-daughter attachment play a pivotal role. Therefore, adopting a staged, multi-modal complex trauma treatment model, aimed at building safety, agency and relationship skills for those seeking help, may offer hope for more successful treatment outcomes.

Further studies on the ultrastructure of the cochlea

1990 ◽  
Vol 48 (3) ◽  
pp. 440-441
Author(s):  
Zhixian Wang ◽  
Pinjin Zhu ◽  
Jianhe Sun ◽  
Xuezheng Song
Keyword(s):  
Hair Cells ◽  
Military Medicine ◽  
Outer Hair Cells ◽  
Apical Surface ◽  
Epithelial Surface ◽  
Hearing Research ◽  
New Findings ◽  
Fine Structures ◽  
Temporal Bones ◽  
Accurate Observation

Hearing research is important not only for clinical, professional and military medicine, but also for toxicology, gerontology and genetics. Ultrastructure of the cochlea attracts much attention of electron microscopists, (1―3) but the research lags far behind that of the other parts of the organnism. On the basis of careful microdissection, technical improvment and accurate observation, we have got some new findings which have not been reported in the literature.We collected four cochleas from human corpses. Temporal bones dissected 1 h after death and cochleas perfused with fixatives 4 h after death were good enough in terms of preservation of fine structures. SEM:The apical surface of OHCs (Outer hair cells) and DTs (Deiters cells) is narrower than that of IPs (Inner pillar cells). The mosaic configuration of the reticular membrane is not typical. The stereocilia of IHCs (Inner hair cells) are not uniform and some kinocilia could be seen on the OHCs in adults. The epithelial surface of RM (Reissner’s membrane) is not smooth and no mesh could be seen on the mesothelial surface of RM. TEM.

Insights into the biochemical and functional characterization of sortase E transpeptidase of Corynebacterium glutamicum

2019 ◽  
Vol 476 (24) ◽  
pp. 3835-3847 ◽  
Author(s):  
Aliyath Susmitha ◽  
Kesavan Madhavan Nampoothiri ◽  
Harsha Bajaj
Keyword(s):  
Protein Engineering ◽  
Cell Attachment ◽  
Functional Characterization ◽  
Protein Structures ◽  
Structural Similarity ◽  
Surface Proteins ◽  
Sortase A ◽  
Peptide Cleavage ◽  
New Findings

Most Gram-positive bacteria contain a membrane-bound transpeptidase known as sortase which covalently incorporates the surface proteins on to the cell wall. The sortase-displayed protein structures are involved in cell attachment, nutrient uptake and aerial hyphae formation. Among the six classes of sortase (A–F), sortase A of S. aureus is the well-characterized housekeeping enzyme considered as an ideal drug target and a valuable biochemical reagent for protein engineering. Similar to SrtA, class E sortase in GC rich bacteria plays a housekeeping role which is not studied extensively. However, C. glutamicum ATCC 13032, an industrially important organism known for amino acid production, carries a single putative sortase (NCgl2838) gene but neither in vitro peptide cleavage activity nor biochemical characterizations have been investigated. Here, we identified that the gene is having a sortase activity and analyzed its structural similarity with Cd-SrtF. The purified enzyme showed a greater affinity toward LAXTG substrate with a calculated KM of 12 ± 1 µM, one of the highest affinities reported for this class of enzyme. Moreover, site-directed mutation studies were carried to ascertain the structure functional relationship of Cg-SrtE and all these are new findings which will enable us to perceive exciting protein engineering applications with this class of enzyme from a non-pathogenic microbe.

Neuropsychologische Befunde bei Anorexia und Bulimia nervosa im Kindes- und Jugendalter

2008 ◽  
Vol 36 (6) ◽  
pp. 377-388 ◽  
Author(s):  
Katharina Bühren ◽  
Kristian Holtkamp ◽  
Beate Herpertz-Dahlmann ◽  
Kerstin Konrad
Keyword(s):  
Bulimia Nervosa ◽  
Psychiatrische Erkrankungen ◽  
Kognitive Leistungsfähigkeit ◽  
Therapeutische Interventionen

Zusammenfassung: Anorexia und Bulimia nervosa sind häufige psychiatrische Erkrankungen des Kindes- und Jugendalters, die insbesondere Mädchen betreffen. Im Akutzustand der Starvation treten bei Essstörungen eine Vielzahl von hormonellen, neuropsychologischen und hirnmorphologischen Veränderungen auf, von denen einige nur teilweise reversibel sind. Komorbide psychiatrische Erkrankungen verkomplizieren das Krankheitsbild und erschweren adäquate therapeutische Interventionen. Der folgende Artikel setzt sich ausführlich mit den neuropsychologischen Defiziten bei Essstörungen, möglichen Einflussfaktoren auf die kognitive Leistungsfähigkeit und daraus resultierenden Implikationen für den klinischen Alltag auseinander.

Perception of Autonomy and Connectedness Prior to the Onset of Anorexia Nervosa and Bulimia Nervosa

2012 ◽  
Vol 40 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Julia Huemer ◽  
Maria Haidvogl ◽  
Fritz Mattejat ◽  
Gudrun Wagner ◽  
Gerald Nobis ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Risk Factor ◽  
Bulimia Nervosa ◽  
Family Environment ◽  
Significant Influence ◽  
Diagnostic Interview ◽  
Individual Autonomy ◽  
Mothers And Fathers ◽  
Image Test ◽  
Restrictive Type

Objective: This study examines retrospective correlates of nonshared family environment prior to onset of disease, by means of multiple familial informants, among anorexia and bulimia nervosa patients. Methods: A total of 332 participants was included (anorexia nervosa, restrictive type (AN-R): n = 41 plus families); bulimic patients (anorexia nervosa, binge-purging type; bulimia nervosa: n = 59 plus families). The EATAET Lifetime Diagnostic Interview was used to establish the diagnosis; the Subjective Family Image Test was used to derive emotional connectedness (EC) and individual autonomy (IA). Results: Bulimic and AN-R patients perceived significantly lower EC prior to onset of disease compared to their healthy sisters. Bulimic patients perceived significantly lower EC prior to onset of disease compared to AN-R patients and compared to their mothers and fathers. A low family sum – sister pairs sum comparison – of EC had a significant influence on the risk of developing bulimia nervosa. Contrary to expectations, AN-R patients did not perceive significantly lower levels of IA compared to their sisters, prior to onset of disease. Findings of low IA in currently ill AN-R patients may represent a disease consequence, not a risk factor. Conclusions: Developmental child psychiatrists should direct their attention to disturbances of EC, which may be present prior to the onset of the disease.

Die Rolle der Ernährungsberatung bei der Behandlung von Anorexia nervosa und Bulimia nervosa

Praxis ◽  
2019 ◽  
Vol 108 (14) ◽  
pp. 931-936
Author(s):  
Sarah Stidwill ◽  
Iris Cook-Müller
Keyword(s):  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Therapeutische Beziehung

Zusammenfassung. Essstörungen wie Anorexia nervosa und Bulimia nervosa werden bevorzugt interdisziplinär therapiert. Neben somatischer und psychologischer/psychiatrischer Fachbegleitung stellt die Ernährungsberatung einen wichtigen Pfeiler dar. Die Er- und Bearbeitung verschiedener Themen wie inkorrektes Ernährungswissen, Hunger und Sättigung, Verbote und schlechtes Gewissen sind zentral. Auf den Erfolg wirkt sich die therapeutische Beziehung zur Ernährungsfachperson aus.

Erfassung dysfunktionaler Kognitionen zum Body Checking

2010 ◽  
Vol 39 (4) ◽  
pp. 251-260 ◽  
Author(s):  
Karolin Neubauer ◽  
Caroline Bender ◽  
Brunna Tuschen-Caffier ◽  
Jennifer Svaldi ◽  
Jens Blechert
Keyword(s):  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Body Checking ◽  
Deutschsprachige Version

Zusammenfassung. Theoretischer Hintergrund: Empirische Befunde zeigen, dass körperbezogenes Kontrollverhalten und die zugrunde liegenden Kognitionen eine zentrale Rolle in der Aufrechterhaltung von Essstörungspsychopathologie spielen. Fragestellung: Eine deutschsprachige Version der Body Checking Cognitions Scale (BCCS) soll teststatistisch überprüft werden. Methode: Frauen mit Anorexia Nervosa (n = 19), Bulimia Nervosa (n = 22) und Binge-Eating Störung (n = 28) sowie eine weibliche nicht-klinische Vergleichsgruppe (n = 195) füllten die BCCS sowie weitere Fragebögen zur Essstörungspsychopathologie aus. Ergebnisse: Das 4-Faktorenmodell der englischsprachigen Originalversion zeigte in Faktorenanalysen die beste Passung. Die deutschsprachige BCCS erwies sich als intern konsistent und zeigte eine zufriedenstellende konvergente und diskriminante Validität. Schlussfolgerungen: Die deutschsprachige BCCS ist ein reliabler und valider Selbstbeurteilungsfragebogen. Sie stellt ein vielversprechendes Instrument zum Einsatz in der Essstörungstherapie und -forschung dar.

Stationäre Behandlung von Kindern und Jugendlichen mit Anorexia nervosa und Bulimia nervosa

2019 ◽  
Vol 28 (4) ◽  
pp. 230-241 ◽  
Author(s):  
Silke Naab ◽  
Markus Fumi ◽  
Sandra Schlegl ◽  
Ulrich Voderholzer
Keyword(s):  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Stationäre Behandlung ◽  
Junge Erwachsene ◽  
Psychische Komorbiditäten ◽  
Schweregrad Der Erkrankung

Zusammenfassung. Anorexia nervosa und Bulimia nervosa betreffen vor allem Jugendliche sowie junge Erwachsene, wobei das Ersterkrankungsalter sinkt, und bei Anorexia nervosa bereits 8-Jährige betroffen sein können. Häufig ist der Verlauf chronisch und kann sowohl schwere körperliche als auch psychische Komorbiditäten nach sich ziehen. Schlimmstenfalls enden Essstörungen tödlich (je nach Schweregrad der Erkrankung Mortalitätsraten bis zu 15 % bei Anorexia nervosa). Ein frühzeitiger Therapiebeginn geht mit einer verbesserten Prognose einher, weshalb die rasche Diagnosestellung von großer Bedeutung ist. Wesentlich hierfür ist die sichere Kenntnis der Diagnosekriterien sowie der essstörungstypischen Folgen. Es werden Aspekte der Symptomatik, Diagnostik, Differentialdiagnostik, Epidemiologie, Pathogenese, Funktionalität, sowie Therapiemöglichkeiten und eigene sowie internationale Studienergebnisse mit Schwerpunkt auf der stationären Therapie von Jugendlichen mit Anorexia nervosa und Bulimia nervosa ausgeführt.

Cognitive Therapy for Anorexia and Bulimia Nervosa

1995 ◽  
Vol 40 (7) ◽  
pp. 695-695
Author(s):  
R. C. Prather
Keyword(s):  
Bulimia Nervosa ◽  
Cognitive Therapy
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