scholarly journals Causes of Death of Rhesus Monkeys Undergoing Liver Transplantation

10.5772/31449 ◽  
2012 ◽  
Author(s):  
Jiang-hua Ran
Keyword(s):  
Liver Transplantation ◽  
Rhesus Monkeys ◽  
Causes Of Death

scholarly journals Causes of death after liver transplantation in 4000 consecutive patients: 2 to 19 year follow-up

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1482-1483 ◽  
Author(s):  
R Kashyap ◽  
A Jain ◽  
J Reyes ◽  
A.J Demetris ◽  
K.A Elmagd ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Causes Of Death

scholarly journals Treatment of Anti-HLA Donor-Specific Antibodies Results in Increased Infectious Complications and Impairs Survival after Liver Transplantation

2020 ◽  
Vol 9 (12) ◽  
pp. 3986
Author(s):  
Sinem Ünlü ◽  
Nils Lachmann ◽  
Maximilian Jara ◽  
Paul Viktor Ritschl ◽  
Leke Wiering ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Causes Of Death ◽  
Human Leukocyte ◽  
Infectious Complications ◽  
Control Group ◽  
Leukocyte Antigen ◽  
High Urgency ◽  
Donor Specific Antibodies ◽  
One Year ◽  
The Relationship

Donor-specific anti-human leukocyte antigen antibodies (DSA) are controversially discussed in the context of liver transplantation (LT). We investigated the relationship between the presence of DSA and the outcome after LT. All the LTs performed at our center between 1 January 2008 and 31 December 2015 were examined. Recipients < 18 years, living donor-, combined, high-urgency-, and re-transplantations were excluded. Out of 510 LTs, 113 DSA-positive cases were propensity score-matched with DSA-negative cases based on the components of the Balance of Risk score. One-, three-, and five-year survival after LT were 74.3% in DSA-positive vs. 84.8% (p = 0.053) in DSA-negative recipients, 71.8% vs. 71.5% (p = 0.821), and 69.3% vs. 64.9% (p = 0.818), respectively. Rejection therapy was more often applied to DSA-positive recipients (n = 77 (68.1%) vs. 37 (32.7%) in the control group, p < 0.001). At one year after LT, 9.7% of DSA-positive patients died due to sepsis compared to 1.8% in the DSA-negative group (p = 0.046). The remaining causes of death were comparable in both groups (cardiovascular 6.2% vs. 8.0%; p = 0.692; hepatic 3.5% vs. 2.7%, p = 0.788; malignancy 3.5% vs. 2.7%, p = 0.788). DSA seem to have an indirect effect on the outcome of adult LTs, impacting decision-making in post-transplant immunosuppression and rejection therapies and ultimately increasing mortality due to infectious complications.

Blood transfusion and graft survival after liver transplantation in rhesus monkeys

1985 ◽  
pp. 34-39
Author(s):  
P. Neuhaus ◽  
C. E. Brölsch ◽  
R. Neuhaus ◽  
W. Lauchart ◽  
F. Vonnahme ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Transfusion ◽  
Graft Survival ◽  
Rhesus Monkeys

scholarly journals Causes of Death and Survival in Alcoholic Cirrhosis Patients Undergoing Liver Transplantation: Influence of the Patient’s Clinical Variables and Transplant Outcome Complications

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 968
Author(s):  
J. M. Bolarín ◽  
M. D. Pérez-Cárceles ◽  
J. P. Hernández del Rincón ◽  
A. Luna ◽  
A. Minguela ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Sudden Death ◽  
Molecular Mechanisms ◽  
Causes Of Death ◽  
Viral Infections ◽  
Multiorgan Failure ◽  
Alcoholic Cirrhosis ◽  
Post Transplantation ◽  
Term Survival ◽  
Clinical Complications

Background. Clinical and molecular mechanisms involved in the cause and time of death of alcoholic cirrhosis (AC) patients undergoing liver transplantation (LT) are not entirely understood. In sudden death cases, judicial autopsy practice is mandatory for determining the cause and circumstances of death. The medico-legal autopsy data are essential for helping health authorities to guide future public health activities, assess the effectiveness of health systems, and adopt the necessary preventive measures to improve and adapt the treatments in order to increase these patients’ survival. Objective. Our study aimed to determine the different clinical and sociodemographic causes that influence the different causes of death and the short- and long-term survival of AC patients undergoing liver transplantation. Methods. A total of 122 deceased AC patients undergoing LT were analyzed at different times post-transplantation. The main pre- and post-transplant complications were analyzed in relation to the cause of death and the patient’s survival, as well as the causes and time at which the patient’s death occurred. Results. A total of 53.3% of non-sudden death was observed. A large number of the deaths of AC patients undergoing transplantation were due to non-sudden death, sepsis, and graft failure (GF), the main causes of death in the sample being similar in both sexes. In non-sudden deaths, there were no significant differences between the death rates either related or not related to the liver transplant. Sepsis was the main cause, with the highest percentage (21.3%) of mortality, followed by GF (18.9%) and multiorgan failure (15.6%) at ten years. Furthermore, our results showed how pre-transplant clinical complications, such as viral infections and encephalopathy, influence the age at which multiorgan failure occurs in the transplanted patient. Conclusion. Multiorgan failure is the leading cause of sudden death, with higher mortality during the first year after transplantation, followed by sepsis and GF. Our results show the vulnerability of AC patients, both in the hospital period after the transplant and outside.

scholarly journals Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits

2021 ◽  
pp. 61-69
Author(s):  
Juan Manuel Diaz ◽  
Ezequiel Mauro ◽  
Maria Nelly Gutierrez-Acevedo ◽  
Adrian Gadano ◽  
Sebastian Marciano
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Causes Of Death ◽  
Meld Score ◽  
Organ Allocation ◽  
Short Term ◽  
Before And After ◽  
Short Term Mortality ◽  
End Stage

Acute-on-chronic liver failure (ACLF) is one of the main causes of death on the waiting list. Liver transplantation (LT) is the only curative treatment for patients with ACLF and therefore it should be considered in all cases. However, the applicability of LT in patients with ACLF is challenging, given the scarcity of donors and the high short-term mortality of these patients. Organ allocation has traditionally been prioritised according to the model for end-stage liver disease (MELD) system. However, the accuracy of MELD score is limited in patients with ACLF. In this article, the authors review the outcomes of patients with ACLF before and after LT, highlighting its clinical course, the feasibility of LT in the sickest patients, the role of the organ allocation system, and possible indicators of futility.

The long-term survival and causes of death in patients who survive at least 1 year after liver transplantation

Surgery ◽  
2002 ◽  
Vol 132 (4) ◽  
pp. 775-780 ◽  
Author(s):  
David P. Vogt ◽  
J.Michael Henderson ◽  
William D. Carey ◽  
David Barnes
Keyword(s):  
Liver Transplantation ◽  
Causes Of Death ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Adult liver transplantation: An analysis of the early causes of death in 40 consecutive cases

Hepatology ◽  
1986 ◽  
Vol 6 (3) ◽  
pp. 495-501 ◽  
Author(s):  
Valentin Cuervas-Mons ◽  
A. Julio Martinez ◽  
Andrew Dekker ◽  
Thomas E. Starzl ◽  
David H. Van Thiel
Keyword(s):  
Liver Transplantation ◽  
Causes Of Death ◽  
Adult Liver

A measles epizootic with 5 deaths in newly-imported rhesus monkeys (Macaca mulatta)

1976 ◽  
Vol 10 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Jenny Remfry
Keyword(s):  
Staphylococcus Aureus ◽  
Antibody Titre ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Causes Of Death ◽  
Aureus Infection ◽  
Macular Rash ◽  
And Staphylococcus Aureus

Of 21 newly-imported rhesus monkeys, 11 showed a typical macular rash and 13 developed a 4-fold or greater rise in antibody titre to measles. 5 animals died, 4 of them with extensive pneumonia, pleurisy and pericarditis. Although measles was involved in each case, there were contributory causes of death, namely Diplococcus pneumoniae and Staphylococcus aureus infection, and infestation with Oesophagostomum (nodular worm) larvae.

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