Failed allografts and causes of death after orthotopic liver transplantation from 1985 to 1995: Decreasing prevalence of irreversible hepatic allograft rejection

1996 ◽  
Vol 2 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Jurgen Ludwig ◽  
Etsuko Hashimoto ◽  
Michael K. Porayko ◽  
Terry M. Therneau
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Allograft Rejection ◽  
Causes Of Death ◽  
Hepatic Allograft

scholarly journals Chronic Rejection and Extrahepatic Biliary Tract Obstruction 8 Years After Orthotopic Liver Transplantation Using the Gallbladder-Conduit Technique

HPB Surgery ◽  
1991 ◽  
Vol 5 (1) ◽  
pp. 17-22 ◽  
Author(s):  
J. Lerut ◽  
A. Zimmermann ◽  
Ph. Gertsch ◽  
R. Preisig ◽  
L. H. Blumgart
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Biliary Tract ◽  
Significant Role ◽  
Allograft Rejection ◽  
Chronic Rejection ◽  
Biliary Obstruction ◽  
Chronic Allograft Rejection ◽  
Extrahepatic Biliary Obstruction

A case of delayed biliary obstruction and cholangitis, occurring in the setting of chronic allograft rejection, 8 years after liver transplantation using the gallbladder-conduit, is presented. Extrahepatic biliary obstruction may be seen in the late follow-up of liver grafting and rejection phenomena may play a significant role in the development of such obstruction.

Evaluation of initial hepatic allograft function with changes of free plasma amino acids in canine orthotopic liver transplantation

1991 ◽  
Vol 50 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Michiyoshi Hisanaga ◽  
Yoshiyuki Nakajima ◽  
Masakazu Segawa ◽  
Hiromichi Kanehiro ◽  
Yoshinori Murao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Amino Acids ◽  
Allograft Function ◽  
Free Plasma ◽  
Hepatic Allograft

Advances in diagnosis, prevention, and management of hepatic allograft rejection

1994 ◽  
Vol 40 (11) ◽  
pp. 2174-2185 ◽  
Author(s):  
R H Wiesner
Keyword(s):  
Liver Transplantation ◽  
Immunosuppressive Therapy ◽  
Allograft Rejection ◽  
Patient Survival ◽  
Rescue Therapy ◽  
Immunosuppressive Agents ◽  
Graft Loss ◽  
Biochemical Tests ◽  
Hepatic Allograft ◽  
Cellular Rejection

Abstract Despite recent improvements in immunosuppressive therapy, hepatic allograft rejection remains a major cause of morbidity and late graft loss in patients undergoing liver transplantation. Although some biochemical tests suggest hepatic allograft damage, the gold standard for defining rejection remains based on morphologic findings. Acute cellular rejection usually occurs within the first 3 weeks posttransplantation and the incidence varies between 40% and 70%. Ductopenic rejection occurs in 5-10% of patients undergoing initial liver transplantation and usually occurs between 6 weeks and 6 months after the procedure. Induction and maintenance of immunosuppression with triple-drug therapy (cyclosporine, prednisone, and azathioprine) and other combinations that include anti-lymphocyte preparations have led to an overall decrease in the incidence of both cellular and ductopenic rejection. In addition, the availability of FK506 as a rescue therapy has saved grafts in some patients experiencing chronic (ductopenic) rejection. Overall, the correlation between the degree of biochemical liver dysfunction and the presence and severity of histologic rejection remains poor. Histologic severity of rejection, however, suggests which patients will require more immunosuppressive therapy and which patients may need antilymphocyte therapy to control the rejection episode. Some rejection episodes remain resistant to all known therapy and eventually lead to graft loss. New immunosuppressive agents and regimens are needed to improve graft and patient survival, decrease the incidence of cellular and ductopenic rejection, minimize drug-related side effects and complications, and reduce the high cost of immunosuppressive therapy.

Histopathology of hepatic allograft rejection after living-related liver transplantation

1998 ◽  
Vol 30 (7) ◽  
pp. 3214-3215 ◽  
Author(s):  
J Sageshima ◽  
S Fuchinoue ◽  
E Hashimoto ◽  
T Koike ◽  
M Abe ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Allograft Rejection ◽  
Living Related Liver Transplantation ◽  
Living Related ◽  
Hepatic Allograft
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