scholarly journals Cellular Level Imaging of the Retina Using Optical Coherence Tomography

10.5772/31391 ◽  
2012 ◽  
Author(s):  
Cherry Greiner ◽  
Stacey S.
Keyword(s):  
Optical Coherence Tomography ◽  
Cellular Level ◽  
Optical Coherence

In vivo 3-D cellular level imaging using Mirau-based full-field optical coherence tomography on skin tissue

2014 ◽  
Author(s):  
Chien-Chung Tsai ◽  
Chia-Kai Chang ◽  
Kuang-Yu Hsu ◽  
Tuan-Shu Ho ◽  
Yu-Ta Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cellular Level ◽  
Skin Tissue ◽  
Optical Coherence ◽  
Full Field

scholarly journals One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging

2015 ◽  
Author(s):  
Dongyao Cui ◽  
Xinyu Liu ◽  
Jing Zhang ◽  
Xiaojun Yu ◽  
Ding Sun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cellular Level ◽  
Optical Coherence

scholarly journals Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

2019 ◽  
Vol 11 (504) ◽  
pp. eaav3505 ◽  
Author(s):  
Hui Min Leung ◽  
Susan E. Birket ◽  
Chulho Hyun ◽  
Timothy N. Ford ◽  
Dongyao Cui ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Optical Coherence Tomography ◽  
Imaging Techniques ◽  
Disease Status ◽  
Cellular Level ◽  
Clear Understanding ◽  
Mucociliary Transport ◽  
Optical Coherence ◽  
Upper Airways ◽  
Cf Transmembrane Conductance Regulator

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although impairment of mucociliary clearance contributes to severe morbidity and mortality in people with CF, a clear understanding of the pathophysiology is lacking. This is, in part, due to the absence of clinical imaging techniques capable of capturing CFTR-dependent functional metrics at the cellular level. Here, we report the clinical translation of a 1-μm resolution micro-optical coherence tomography (μOCT) technology to quantitatively characterize the functional microanatomy of human upper airways. Using a minimally invasive intranasal imaging approach, we performed a clinical study on age- and sex-matched CF and control groups. We observed delayed mucociliary transport rate at the cellular level, depletion of periciliary liquid layer, and prevalent loss of ciliation in subjects with CF. Distinctive morphological differences in mucus and various forms of epithelial injury were also revealed by μOCT imaging and had prominent effects on the mucociliary transport apparatus. Elevated mucus reflectance intensity in CF, a proxy for viscosity in situ, had a dominant effect. These results demonstrate the utility of μOCT to determine epithelial function and monitor disease status of CF airways on a per-patient basis, with applicability for other diseases of mucus clearance.

scholarly journals Micro Optical Coherence Tomography for Coronary Imaging

2021 ◽  
Vol 8 ◽  
Author(s):  
Kensuke Nishimiya ◽  
Guillermo Tearney
Keyword(s):  
Optical Coherence Tomography ◽  
New Technology ◽  
Healing Process ◽  
Coronary Plaque ◽  
Cellular Level ◽  
Optical Coherence ◽  
History Of ◽  
Intravascular Optical Coherence Tomography ◽  
Revascularization Therapy ◽  
Progression Prediction

Intravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This issue has motivated the development of a next-generation form of OCT imaging that offers higher resolution. One such technology that we review here is termed micro-OCT (μOCT) that enables the assessment of the cellular and subcellular morphology of human coronary atherosclerotic plaques. This chapter reviews recent advances and ongoing works regarding μOCT in the field of cardiology. This new technology has the potential to provide researchers and clinicians with a tool to better understand the natural history of coronary atherosclerosis, increase plaque progression prediction capabilities, and better assess the vessel healing process after revascularization therapy.

Non-Contact Full-Field Optical Coherence Tomography: A Step Towards In-Vivo Cellular-Level Imaging of the Human Cornea

2016 ◽  
Author(s):  
Viacheslav Mazlin ◽  
Eugénie Dalimier ◽  
Kate Grieve ◽  
Kristina Irsch ◽  
José Sahel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cellular Level ◽  
Human Cornea ◽  
Optical Coherence ◽  
Full Field

Imaging the living retina at the cellular level with AO parallel spectral-domain optical coherence tomography

2005 ◽  
Author(s):  
Donald T. Miller ◽  
Yan Zhang ◽  
Jungtae Rha ◽  
Ravi S. Jonnal ◽  
Weihua Gao
Keyword(s):  
Optical Coherence Tomography ◽  
Cellular Level ◽  
Spectral Domain ◽  
Optical Coherence
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