scholarly journals Endocytosis and Exocytosis in Signal Transduction and in Cell Migration

10.5772/30754 ◽  
2012 ◽  
Author(s):  
Guido Serini ◽  
Sara Sigismund ◽  
Letizia Lanzetti
Keyword(s):  
Signal Transduction ◽  
Cell Migration

scholarly journals Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways

2020 ◽  
Vol 295 (50) ◽  
pp. 16906-16919
Author(s):  
Jae-Hong Kim ◽  
Yeojin Seo ◽  
Myungjin Jo ◽  
Hyejin Jeon ◽  
Young-Seop Kim ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Intracellular Signaling ◽  
Mammalian Cells ◽  
Drug Targets ◽  
Large Scale ◽  
Genetic Interaction ◽  
Genetic Interactions ◽  
Signal Transduction Pathways ◽  
Global View

Kinases are critical components of intracellular signaling pathways and have been extensively investigated with regard to their roles in cancer. p21-activated kinase-1 (PAK1) is a serine/threonine kinase that has been previously implicated in numerous biological processes, such as cell migration, cell cycle progression, cell motility, invasion, and angiogenesis, in glioma and other cancers. However, the signaling network linked to PAK1 is not fully defined. We previously reported a large-scale yeast genetic interaction screen using toxicity as a readout to identify candidate PAK1 genetic interactions. En masse transformation of the PAK1 gene into 4,653 homozygous diploid Saccharomyces cerevisiae yeast deletion mutants identified ∼400 candidates that suppressed yeast toxicity. Here we selected 19 candidate PAK1 genetic interactions that had human orthologs and were expressed in glioma for further examination in mammalian cells, brain slice cultures, and orthotopic glioma models. RNAi and pharmacological inhibition of potential PAK1 interactors confirmed that DPP4, KIF11, mTOR, PKM2, SGPP1, TTK, and YWHAE regulate PAK1-induced cell migration and revealed the importance of genes related to the mitotic spindle, proteolysis, autophagy, and metabolism in PAK1-mediated glioma cell migration, drug resistance, and proliferation. AKT1 was further identified as a downstream mediator of the PAK1-TTK genetic interaction. Taken together, these data provide a global view of PAK1-mediated signal transduction pathways and point to potential new drug targets for glioma therapy.

A surface-engineered NIR light-responsive actuator for controllable modulation of collective cell migration

2019 ◽  
Vol 7 (36) ◽  
pp. 5528-5534 ◽  
Author(s):  
Jiayu Liu ◽  
Jinhui Shang ◽  
Yancao Chen ◽  
Yueyue Tian ◽  
Qian Yang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Live Cells ◽  
Collective Cell Migration ◽  
Nir Light ◽  
Mechanical Signal

A surface-engineered NIR light-responsive actuator has been presented for manipulating collective cell migration by activating mechanical signal transduction in live cells.

scholarly journals Healing of Gastrointestinal Mucosa: Involvement of Polyamines

Physiology ◽  
1999 ◽  
Vol 14 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Leonard R. Johnson ◽  
Shirley A. McCormack
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Growth Factor ◽  
Egf Receptor ◽  
Receptor Function ◽  
Gastrointestinal Mucosa ◽  
Cellular Content ◽  
Mucosal Lesions ◽  
Signal Transduction Proteins ◽  
Cell Migration And Proliferation

Polyamines are involved in the processes of cell migration and proliferation that result in the repair of mucosal lesions. Depletion of polyamines dramatically alters the arrangement of the cytoskeleton, EGF receptor function, the activities of signal transduction proteins, the levels of several protooncogenes, and the expression and cellular content of at least one growth factor involved in these processes.

Focal adhesion kinase: at the crossroads of signal transduction

1997 ◽  
Vol 110 (4) ◽  
pp. 401-407 ◽  
Author(s):  
D. Ilic ◽  
C.H. Damsky ◽  
T. Yamamoto
Keyword(s):  
Signal Transduction ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Signaling Pathways ◽  
Focal Adhesion ◽  
Nonreceptor Tyrosine Kinase ◽  
Definitive Evidence ◽  
Multiple Signaling

Morphogenetic processes during development, including cell migration, depend on signals from both the extracellular matrix (ECM) and soluble signaling factors. Extensive evidence has shown that the nonreceptor tyrosine kinase, focal adhesion kinase (FAK), is activated in response to both kind of signal. The most definitive evidence that FAK is directly downstream of signals initiated by the ECM comes from comparing the phenotypes of mice deficient for FAK and the ECM molecule, fibronectin: in both cases embryos die at about E8.5 and display almost identical severe vascular and other mesodermal defects. It is now clear that there are additional FAK-like proteins, indicating the existence of a FAK family. Furthermore, FAK is not located at adhesive sites in all cells where it is expressed. This, plus extensive data indicating that FAK becomes activated in response to several soluble signaling factors, suggests that the FAK family may be at the crossroads of multiple signaling pathways that affect cell and developmental processes.

scholarly journals Excitable Signal Transduction Networks in Directed Cell Migration

2017 ◽  
Vol 33 (1) ◽  
pp. 103-125 ◽  
Author(s):  
Peter N. Devreotes ◽  
Sayak Bhattacharya ◽  
Marc Edwards ◽  
Pablo A. Iglesias ◽  
Thomas Lampert ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Directed Cell Migration ◽  
Signal Transduction Networks

Platelet-Derived Growth Factor-BB Stimulated Cell Migration Mediated Through p38 Signal Transduction Pathway in Periodontal Cells

2003 ◽  
Vol 74 (9) ◽  
pp. 1320-1328 ◽  
Author(s):  
Angel K. Ray ◽  
Anne C. Jones ◽  
David L. Carnes ◽  
David L. Cochran ◽  
James T. Mellonig ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Migration ◽  
Growth Factor ◽  
Signal Transduction Pathway ◽  
Platelet Derived Growth Factor ◽  
Transduction Pathway
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