scholarly journals Exercise Performance and Breathing Patterns in Cystic Fibrosis

10.5772/29872 ◽  
2012 ◽  
Author(s):  
Georgia Perpati
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Breathing Patterns

scholarly journals Cystic fibrosis mice display different breathing patterns than non‐CF mice

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Cara K Campanaro ◽  
Rebecca J Darrah ◽  
Thomas E Dick ◽  
Mitchell L Drumm ◽  
Frank J Jacono
Keyword(s):  
Cystic Fibrosis ◽  
Breathing Patterns

scholarly journals Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Bradley S. Quon ◽  
Andrew H. Ramsook ◽  
Satvir S. Dhillon ◽  
Reid A. Mitchell ◽  
Kyle G. Boyle ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Short Term ◽  
Ventilatory Responses ◽  
Short Term Effects

scholarly journals 204 Clinical and functional determinants of exercise performance in adults with cystic fibrosis

2013 ◽  
Vol 12 ◽  
pp. S100
Author(s):  
J. Pastre ◽  
A. Prevotat ◽  
C. Tardif ◽  
A. Mammar ◽  
J.M. Perruchini ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance

scholarly journals ePS04.10 Evaluation of exercise performance with Godfrey cycle protocol: experience of the cystic fibrosis (CF) center of Milan

2016 ◽  
Vol 15 ◽  
pp. S45-S46
Author(s):  
F. Carta ◽  
S. Gambazza ◽  
A. Brivio ◽  
E. Caverni ◽  
M. Foà ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance

Exercise Performance and Rehabilitation in Cystic Fibrosis

1997 ◽  
Vol 9 (1) ◽  
pp. 1-33 ◽  
Author(s):  
Peter T. P. Bye ◽  
Jennifer A. Alison ◽  
Jeff A. Regnis
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance

scholarly journals Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

2013 ◽  
Vol 58 (2) ◽  
pp. 291-297 ◽  
Author(s):  
A. D. Sovtic ◽  
P. B. Minic ◽  
J. Kosutic ◽  
G. P. Markovic-Sovtic ◽  
M. B. Gajic
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Peak Exercise

scholarly journals Deposition of Inhaled Levofloxacin in Cystic Fibrosis Lungs Assessed by Functional Respiratory Imaging

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2051
Author(s):  
Carsten Schwarz ◽  
Claudio Procaccianti ◽  
Benjamin Mignot ◽  
Hosein Sadafi ◽  
Nicolas Schwenck ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Three Dimensional ◽  
Lung Deposition ◽  
Dynamics Simulation ◽  
Breathing Patterns ◽  
High Resolution Computed Tomography ◽  
Structural Differences ◽  
Lower Lung ◽  
Lung Periphery ◽  
Modest Correlation

Pulmonary infections caused by Pseudomonas aeruginosa (PA) represent the leading cause of pulmonary morbidity in adults with cystic fibrosis (CF). In addition to tobramycin, colistin, and aztreonam, levofloxacin has been approved in Europe to treat PA infections. Nevertheless, no lung deposition data on inhaled levofloxacin are yet available. We conducted a Functional Respiratory Imaging (FRI) study to predict the lung deposition of levofloxacin in the lungs of patients with CF. Three-dimensional airway models were digitally reconstructed from twenty high-resolution computed tomography scans obtained from historical patients’ records. Levofloxacin aerosols generated with the corresponding approved nebuliser were characterised according to pharmacopeia. The obtained data were used to inform a computational fluid dynamics simulation of levofloxacin lung deposition using breathing patterns averaged from actual CF patients’ spirometry data. Levofloxacin deposition in the lung periphery was significantly reduced by breathing patterns with low inspiratory times and high inspiratory flow rates. The intrathoracic levofloxacin deposition percentages for moderate and mild CF lungs were, respectively, 37.0% ± 13.6 and 39.5% ± 12.9 of the nominal dose. A significant albeit modest correlation was found between the central-to-peripheral deposition (C/P) ratio of levofloxacin and FEV1. FRI analysis also detected structural differences between mild and moderate CF airways. FRI revealed a significant intrathoracic deposition of levofloxacin aerosols, which distributed preferentially to the lower lung lobes, with an influence of the deterioration of FEV1 on the C/P ratio. The three-dimensional rendering of CF airways also detected structural differences between the airways of patients with mild and moderate CF.

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