scholarly journals Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

2013 ◽  
Vol 58 (2) ◽  
pp. 291-297 ◽  
Author(s):  
A. D. Sovtic ◽  
P. B. Minic ◽  
J. Kosutic ◽  
G. P. Markovic-Sovtic ◽  
M. B. Gajic
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Peak Exercise

scholarly journals Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Bradley S. Quon ◽  
Andrew H. Ramsook ◽  
Satvir S. Dhillon ◽  
Reid A. Mitchell ◽  
Kyle G. Boyle ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance ◽  
Short Term ◽  
Ventilatory Responses ◽  
Short Term Effects

scholarly journals 204 Clinical and functional determinants of exercise performance in adults with cystic fibrosis

2013 ◽  
Vol 12 ◽  
pp. S100
Author(s):  
J. Pastre ◽  
A. Prevotat ◽  
C. Tardif ◽  
A. Mammar ◽  
J.M. Perruchini ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance

Effect of exercise training on skeletal muscle histology and metabolism in peripheral arterial disease

1996 ◽  
Vol 81 (2) ◽  
pp. 780-788 ◽  
Author(s):  
W. R. Hiatt ◽  
J. G. Regensteiner ◽  
E. E. Wolfel ◽  
M. R. Carry ◽  
E. P. Brass
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Exercise Performance ◽  
Citrate Synthase ◽  
Normal Subjects ◽  
Arterial Occlusive Disease ◽  
Treadmill Training ◽  
Peak Exercise ◽  
Muscle Histology ◽  
Peripheral Arterial

Patients with symptomatic peripheral arterial occlusive disease have a claudication-limited peak exercise performance that is improved with exercise training. The effects of training on skeletal muscle metabolism were evaluated in 26 patients with claudication, randomized into a 12-wk program of treadmill training (enhances muscle metabolic activity in normal subjects), strength training (stimulates muscle hypertrophy in normal subjects), or a nonexercising control group. Gastrocnemius muscle biopsies were performed at rest and before and after training. After 12 wk, only treadmill training improved peak exercise performance and peak oxygen consumption. Treadmill training did not alter type I or type II fiber area and did not increase citrate synthase activity but was associated with an increase in the percentage of denervated fibers (from 7.6 +/- 5.4 to 15.6 +/- 7.5%, P < 0.05). Improvement in exercise performance with treadmill training was associated with a correlative decrease in the plasma (r = -0.67) and muscle (r = -0.59) short-chain acylcarnitine concentrations (intermediates of oxidative metabolism). Patients in the strength and control groups had no changes in muscle histology or carnitine metabolism, but strength-trained subjects had a decrease in citrate synthase activity. Thus treadmill training increased peak exercise performance, but this benefit was associated with skeletal muscle denervation and the absence of a "classic" mitochondrial training response (increase in citrate synthase activity). The present study confirms the relationship between skeletal muscle acylcarnitine content and function in peripheral arterial occlusive disease, demonstrating that the response to treadmill training was associated with parallel improvements in intermediary metabolism.

scholarly journals ePS04.10 Evaluation of exercise performance with Godfrey cycle protocol: experience of the cystic fibrosis (CF) center of Milan

2016 ◽  
Vol 15 ◽  
pp. S45-S46
Author(s):  
F. Carta ◽  
S. Gambazza ◽  
A. Brivio ◽  
E. Caverni ◽  
M. Foà ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Performance

Modified Chrispin-Norman Score: Correlation With Peak Exercise Capacity and Efficiency of Ventilation in Children With Cystic Fibrosis

2014 ◽  
Vol 26 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Aleksandar Sovtic ◽  
Predrag Minic ◽  
Jovan Kosutic ◽  
Gordana Markovic-Sovtic ◽  
Milan Gajic
Keyword(s):  
Cystic Fibrosis ◽  
Exercise Capacity ◽  
Cardiopulmonary Exercise Testing ◽  
Cycle Ergometer ◽  
Peak Oxygen Consumption ◽  
Whole Body ◽  
Peak Exercise ◽  
Stepwise Multiple Linear Regression ◽  
Radiographic Changes ◽  
Whole Body Plethysmography

The modified Chrispin-Norman radiography score (CNS) is used in evaluation of radiographic changes in children with cystic fibrosis (CF). We evaluated the correlation of modified CNS with peak exercise capacity (Wpeak) and ventilatory efficiency (reflected by breathing reserve index—BRI) during progressive cardiopulmonary exercise testing (CPET). Thirty-six children aged 8–17 years were stratified according to their CNS into 3 groups: mild (<10), moderate (10–15), and severe (>15). CPET was performed on a cycle ergometer. Lung function tests included spirometry and whole-body plethysmography. Patients with higher CNS had lower FEV1 (p < .001), Wpeak predicted (%; p = .01) and lower mean peak oxygen consumption (VO2peak/kg; p = .014). The BRI at the anaerobic threshold and at Wpeak was elevated in patients with the highest CNS values (p < .001). The modified CNS correlates moderately with Wpeak (R = −0.443; p = .007) and BRI (R = −0.419; p = .011). Stepwise multiple linear regression showed that RV/TLC was the best predictor of Wpeak/pred (%; B = −0.165; b = −0.494; R2 = .244; p = .002). Children with CF who have high modified CNS exhibit decreased exercise tolerance and ventilatory inefficacy during progressive effort.

Endothelial dysfunction and exercise performance in lone atrial fibrillation or associated with hypertension or diabetes: different results with cardioversion

2006 ◽  
Vol 291 (2) ◽  
pp. H921-H928 ◽  
Author(s):  
Marco Guazzi ◽  
Sebastiano Belletti ◽  
Elisabetta Bianco ◽  
Laura Lenatti ◽  
Maurizio D. Guazzi
Keyword(s):  
Atrial Fibrillation ◽  
Endothelial Dysfunction ◽  
Exercise Performance ◽  
Oxidative Injury ◽  
Exercise Intolerance ◽  
Peak Exercise ◽  
Flow Mediated Dilation ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Endothelial dysfunction and underperfusion of exercising muscle contribute to exercise intolerance, hyperventilation, and breathlessness in atrial fibrillation (AF). Cardioversion (CV) improves endothelial function and exercise performance. We examined whether CV is equally beneficial in diabetes and hypertension, diseases that cause endothelial dysfunction and are often associated with AF. Cardiopulmonary exercise and pulmonary and endothelial (brachial artery flow-mediated dilation) function were tested before and after CV in patients with AF alone ( n = 18, group 1) or AF with hypertension ( n = 19, group 2) or diabetes ( n = 19, group 3). Compared with group 1, peak exercise workload, O2 consumption (V̇o2), O2 pulse, aerobic efficiency (ΔV̇o2/ΔWR), and ratio of brachial diameter changes to flow changes (Δ D/ΔF) were reduced in group 2 and, to a greater extent, in group 3; exercise ventilation efficiency (V̇e/V̇co2 slope) and dead space-to-tidal volume ratio (Vd/Vt) were similar among groups. CV had less effect on peak workload (+7% vs. +18%), peak V̇o2 (+12% vs. +17%), O2 pulse (+33% vs. +50%), ΔV̇o2/ΔWR (+7% vs. +12%), V̇e/V̇co2 slope (−6% vs. −12%), Δ D/ΔF (+7% vs. +10%), and breathlessness (Borg scale) in group 2 than in group 1 and was ineffective in group 3. The antioxidant vitamin C, tested in eight additional patients in each cohort, improved flow-mediated dilation in groups 1 and 2 before, but not after, CV and was ineffective in group 3, suggesting that the oxidative injury is least in lone AF, greater in hypertension with AF, and greater still in diabetes with AF. Comorbidities that impair endothelial activity worsen endothelial dysfunction and exercise intolerance in AF. The advantages of CV appear to be inversely related to the extent of the underlying oxidative injury.

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