scholarly journals Clinical Features of Ankylosing Spondylitis

10.5772/29655 ◽  
2012 ◽  
Author(s):  
Jeanette Wolf
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features

Clinical features of ankylosing spondylitis may correlate with HLA-B27 polymorphism

2008 ◽  
Vol 29 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Zhen Wu ◽  
Zhiming Lin ◽  
Qiujing Wei ◽  
Jieruo Gu
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Hla B27

Clinical features of gastrointestinal tractus damage in patients with ankylosing spondylitis

Therapy ◽  
2019 ◽  
Vol 1_2019 ◽  
pp. 119-124
Author(s):  
Belousova E.N. Belousova ◽  
Protopopov M.S. Protopopov ◽  
Abdulganieva D.I. Abdulganieva ◽  
◽  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features

Clinical features and management of ankylosing spondylitis

1993 ◽  
Vol 5 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Cesar Ramos-Remus ◽  
Anthony S. Russell
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features

scholarly journals Structural Lesion Progression of the Sacroiliac Joint and Clinical Features in axSpA During TNFi Reduction: A Retrospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Qian Mo ◽  
Yuanji Dong ◽  
Cong Ye ◽  
Jixin Zhong ◽  
Shaozhe Cai ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Treatment Response ◽  
Clinical Features ◽  
Sacroiliac Joint ◽  
Activity Index ◽  
Tumor Necrosis Factor Inhibitor ◽  
Average Dose ◽  
Structural Progression ◽  
The Status

Objective: In the clinic, some patients with axial spondyloarthritis (axSpA) have to reduce tumor necrosis factor inhibitor (TNFi) for various reasons. However, there are few studies about how to balance the relapse and TNFi reduction. Here we retrospectively analyzed the structural progression of the sacroiliac joint (SIJ) and clinical features in axSpA during TNFi reduction.Methods: A total of 108 patients with axSpA who followed up for 2 years and completed at least baseline, 12-month, and 24-month MRI scans of SIJ were divided into the tapering group (n = 63) and withdrawal group (n = 45) according to whether TNFi was stopped. We divided 2 years into five intervals, calculating the average dose quotient (DQ) for each of 540 intervals from 108 patients. By using generalized estimation equations with inverse probability of treatment weighting, we investigated the unbiased effects of average DQ on structural progression and treatment response.Results: The disease activity (such as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, and ASDAS-ESR) and relapse rate were lower in the tapering group at 12 and 24 months (p < 0.05). Δerosion (β = −0.0100, p = 0.00026) and Δthe Spondyloarthritis Research Consortium of Canada (SPARCC; β = −0.0959, p < 0.0001) were negatively correlated with average DQ. The average DQ 30 (74.8%, 80.0%) or 41.6 (76.5%, 83%) was best to discriminate the status of treatment response or the status of bone marrow edema, but considering operability, the average DQ 25 (78.0%, 63.3%) was also acceptable especially for patients with HLA-B27 negative and non-severe fat metaplasia.Conclusion: Complete TNFi withdrawal was not recommended. Our study provided a referable strategy (tapering then maintained the average DQ over 30 or even 25) for patients who need TNFi reduction. Higher dose usage of TNFi was associated with a slower erosion progression of SIJ.

scholarly journals A REVIEW OF CLINICAL FEATURES AND X-RAY IMAGES IN PATIENTS WITH ANKYLOSING SPONDYLITIS WHO UNDERWENT TOTAL HIP ARTHROPLASTY

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Nguyen Quoc Dung ◽  
Nguyen Anh Tuan
Keyword(s):  
Ankylosing Spondylitis ◽  
Total Hip Arthroplasty ◽  
Clinical Features ◽  
Hip Arthroplasty ◽  
Stage Ii ◽  
Spinal Curvature ◽  
Stage Iii ◽  
Cross Sectional ◽  
X Ray ◽  
Total Hip

Objective: To describe some clinical features and X - ray images of patients with ankylosing spondylitis who underwent total hip arthroplasty. Subject and method: This is a descriptive and cross-sectional study. 10 male patients with ankylosing spondylitis including 13 hips were underwent total hip arthroplasty using cement-less cup at The Joint Surgery Department of 108 Military Central Hospital from May 2015 to May 2019. The mean follow-up period was 33 months (range from 6 to 56 months). Result and conclusion: The combined form accounts for 9/10 patients. 10/10 patients in the research group were operated at the onset of the disease. Limitation and loss of movement of the cervical spine occurred to 7/10 patients, 8/10 patients with thoracic spine and 9/10 patients with lumbar spine. All 10 patients had injured hip in both sides. 9/13 hips suffered intense and consecutive pain. 11/13 patients suffered from loss of hip movement before surgery). 10/10 patients had signs of loss of spinal curvature, railway spine found in 4/10 patients, images of bone bridges and bamboo spine were presented in 5/10 patients. Damages to pelvic joint mainly occurred during stage III - IV with 12/13 joints, 1/13 joint during stage II. Injury to stage III and IV hips, according to BASRI - h accounted for 11/13 hip joints, 2/13 in stage II. The quality of the femur classified by Dorr type A accounted for 7/13 femur, type B accounted for 3/13 femur, type C accounted for 3/13 femur.

Genetics of spondyloarthropathies

2016 ◽  
Author(s):  
Matthew Brown
Keyword(s):  
Risk Factors ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Signalling Pathway ◽  
Diverse Group ◽  
Novel Treatments

Spondyloarthropathies are a diverse group of conditions, of which ankylosing spondylitis is the prototypic disease, with shared clinical features, genetic risk factors, and histopathological characteristics. These conditions are highly familial and heritable. Several genes have been associated with spondyloarthropathies, with genes in the IL-23 signalling pathway being shared by the major types of spondyloarthritis. These discoveries have already led to the development and successful clinical introduction of novel treatments for psoriasis and psoriatic arthritis, and major advances in our understanding of the pathogenesis of the conditions. Many more genes remain to be identified which are involved in these common conditions; identifying these genes is likely to be highly informative as to their causes.

scholarly journals Comparison in clinical features and life impact between juvenile-onset and adult-onset ankylosing spondylitis

2014 ◽  
Vol 44 ◽  
pp. 601-605 ◽  
Author(s):  
Mingqiang GUAN ◽  
Jian WANG ◽  
Zhigang ZHU ◽  
Jun XIAO ◽  
Liang ZHAO ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Adult Onset ◽  
Juvenile Onset ◽  
Life Impact
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