Juvenile ankylosing spondylitis, its clinical features and HLA-B27

1977 ◽  
Vol 87 (1) ◽  
pp. 31-37 ◽  
Author(s):  
H. Mitsui ◽  
T. Juji ◽  
H. Sonozaki
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Hla B27 ◽  
Juvenile Ankylosing Spondylitis

Spontaneous atlantoaxial subluxation as a presenting manifestation of juvenile ankylosing spondylitis in a female HLA-B27-negative patient

2005 ◽  
Vol 164 (7) ◽  
pp. 455-457 ◽  
Author(s):  
Luciana Breda ◽  
Carlo Palazzi ◽  
Giuseppina de Michele ◽  
Sara De Sanctis ◽  
Francesco Chiarelli
Keyword(s):  
Ankylosing Spondylitis ◽  
Atlantoaxial Subluxation ◽  
Hla B27 ◽  
Negative Patient ◽  
Juvenile Ankylosing Spondylitis

Clinical features of ankylosing spondylitis may correlate with HLA-B27 polymorphism

2008 ◽  
Vol 29 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Zhen Wu ◽  
Zhiming Lin ◽  
Qiujing Wei ◽  
Jieruo Gu
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Hla B27

scholarly journals Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?

2018 ◽  
Vol 11 ◽  
pp. 117954411775162 ◽  
Author(s):  
Amal Akassou ◽  
Youssef Bakri
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Human Disease ◽  
Scientific Community ◽  
Hla B27 ◽  
Specific Interest

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27–based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.

Correlation of HLA B27 subtypes with clinical features of ankylosing spondylitis

2011 ◽  
Vol 14 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Himangi CHAVAN ◽  
Rohini SAMANT ◽  
Anand DESHPANDE ◽  
Ranjit MANKESHWAR
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Hla B27

scholarly journals Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort

2017 ◽  
Vol 102 (2) ◽  
pp. 215-219 ◽  
Author(s):  
Peizeng Yang ◽  
Wenjuan Wan ◽  
Liping Du ◽  
Qingyun Zhou ◽  
Jian Qi ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Human Leucocyte Antigen ◽  
Visual Outcome ◽  
Secondary Glaucoma ◽  
Vascular Involvement ◽  
Hla B27 ◽  
Acute Anterior Uveitis ◽  
Complicated Cataract

AimsTo characterise the clinical features of human leucocyte antigen (HLA)-B27+acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients.MethodsA total of 1056 HLA-B27+ AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27+AS+ and HLA-B27+AS− group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups.ResultsThere were 581 (55.0%) and 475 (45.0%) patients respectively classified into HLA-B27+AS+ and HLA-B27+AS− group. Males had a higher prevalence than females in the HLA-B27+AS+ group (75.2%) as compared with the HLA-B27+AS− group (51.8%, p<0.001). The HLA-B27+AS+ patients showed a higher percentage of bilateral/alternating involvement (47.3%) as compared with the HLA-B27+AS− group (36.6%, p=0.001). A higher percentage of fibrinous exudation, synechiae as well as complications including complicated cataract and secondary glaucoma were found in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group. Worse visual outcome as indicated by a higher percentage of patients with BCVA <0.5 and with BCVA <0.05 was noted in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group both before and after treatment. FFA showed mild capillary fluorescence leakage in the late phase with indistinctly defined margins on the peripheral retina in 39.3% of HLA-B27+ AAU patients. There was no difference concerning the retinal vascular involvement between these two groups.ConclusionsOur study confirmed that HLA-B27+AS+ patients show a higher percentage of males, more common bilateral involvement, a higher frequency of fibrinous exudates, synechiae and secondary glaucoma as compared with HLA-B27+AS− patients. Visual outcome was poorer, possibly due to the higher prevalence of complicated cataract in HLA-B27+AS+ patients. Retinal vascular involvement was not uncommon in HLA-B27+ AAU patients.

scholarly journals P185 Does BASDAI score correlate to MRI changes in ankylosing spondylarthritis?

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Nibha Jain ◽  
Swetha Byravan Byravan ◽  
Jenna Stairs ◽  
Winston Rennie ◽  
Moorthy Arumugam
Keyword(s):  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Clinical Features ◽  
Activity Index ◽  
Outcome Measurement ◽  
Disease Activity Index ◽  
Inflammatory Back Pain ◽  
Hla B27 ◽  
Mri Changes

Abstract Background/Aims  The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is routinely used subjective outcome measurement of disease activity in Ankylosing Spondylitis (AS). BASDAI &gt; 4 is used as a criterion for commencing anti-TNF therapy. Previous studies shown BASDAI correlation with MRI has been proven to be weak. We did this study to systemically compare clinical and radiological data of patients with AS and to look for the degree of correlation between BASDAI score and MRI changes positive for spondyloarthritis in our cohort of patients. Methods  A retrospective analysis of AS patients attending Leicester spondylarthritis service at University Hospitals Leicester Trust (UHL) was carried out. Clinical characteristics such as HLA-B27 status, extra-articular features, family history of AS and CRP measurement were obtained from online systems and clinic letters. Online records were reviewed to see if patients had a MRI of the sacroiliac joints along with a BASDAI score at the time of MRI. Medcalc calculator was used for statistical analysis. Results  A total of 106 patients were analysed with a mean age of 45.6 +/- 11.6 years (M = 62, F = 44) with mean BASDAI of 5.0 +/- 2.5. Mean CRP was 17.01+/- 30.4 (median CRP 6.5). 61% (n = 65) were HLA-B27 positive. 70 of 106 patients had a sacroiliac MRI scan which could be reviewed to a satisfactory level to determine whether disease is present or not. Two results were statistically significant when comparing active versus no active lesions on MRI: inflammatory back pain and anti-TNF therapy (Table 1). P185 Table 1:Comparison of clinical features in patients with active versus inactive lesions on MRI sacroiliac joint.Active lesions on MRI N = 45No active lesions on MRI N = 25P valueMean BASDAI (SD)5.0 (2.6)5.4(2.6)0.5Mean ASDAS CRP (SD)2.14(1.1)2.04(0.6)0.73Mean CRP (SD) mg/l14.7(21)17.8(33)0.645.5HLA-B2731180.Uveitis1190.3Inflammatory back pain40170.03Enthesitis820.3Peripheral Arthritis670.1Dactylitis010.2Psoriasis211Inflammatory bowel disease710.1Ethnicity: Caucasian37230.2Ethnicity: Asian820.3Age45.5 (10.2)50.5(11.3)0.06M: F26:1916:90.7Anti-TNF therapy1840.03BASDAI &gt;428150.8BASDAI &lt;417100.8BASDAI= Bath ankylosing spondylitis disease activity index, ASDAS= Ankylosing Spondylitis disease. CRP=C-reactive protein, HLA= human leucocyte antigen. Conclusion  BASDAI score did not statistically correlate with the severity of inflammation as objectively observed on MRI. Only inflammatory back pain and anti-TNF therapy correlated with MRI disease activity. There was no difference in clinical features including HLA-B27 between patients with active and inactive MRI. Thus, BASDAI as a criterion for biologic therapy may need re-considering. Disclosure  N. Jain: None. S. Byravan: None. J. Stairs: None. W. Rennie: None. M. Arumugam: Other; Speaker and Conference Fee MSD, Novartis, Abbvie.

scholarly journals A Nationwide Questionnaire Survey on the Prevalence of Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in Japan

2021 ◽  
Author(s):  
Yuri Matsubara ◽  
Yosikazu Nakamura ◽  
Naoto Tamura ◽  
Hideto Kameda ◽  
Kotaro Otomo ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Axial Spondyloarthritis ◽  
Age Of Onset ◽  
Human Leukocyte ◽  
Hla B27 ◽  
Lower Prevalence ◽  
Nationwide Study ◽  
Leukocyte Antigen ◽  
Positive Rate

Abstract Objective This nationwide study aimed to reveal the prevalence of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-ax SpA), and the positive rate of human leukocyte antigen (HLA) among these patients in Japan. Methods The first survey was conducted in 2221 randomly selected facilities (26.3%) in September, 2018, where the patients with AS/nr-ax SpA were taken care of from January to December, 2017. We estimated the total number of these patients using response and extraction rate. A second survey was conducted in 117 facilities (49.8%) to assess for HLA-B 27 positivity rate and clinical features. Results The estimated total number of the patients with AS and nr-ax SpA were 3200 (95% confidence interval [CI]: 2400–3900) and 800 (530–1100), suggesting that the prevalence of AS and nr-ax SpA in general population were 2.6/100,000 (0.0026%) and 0.6/100,000 (0.0006%), respectively. Although 55.5 % (76/137) of patients with AS were HLA-B27 positive, those whose age of onset was estimated to be over 50 years tended to undergo less HLA-B27 testing. Conclusion This study revealed the lower prevalence of AS/nr-ax SpA in Japan, compared to those in other countries. Further studies are required to reveal the association of HLA-B27 with the clinical features.

HLA-B27 Homozygosity and Clinical Features of Ankylosing Spondylitis

2010 ◽  
Vol 12 (5) ◽  
pp. 309-310
Author(s):  
Marina Magrey ◽  
Muhammad Asim Khan
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Hla B27
Sign in / Sign up

Export Citation Format

Share Document