Homelessness as an Incurable Condition? The Medicalization of the Homeless in the Swedish Special Housing Provision

This article argues that urban governance, and academic theorisations of it, have focused on the role and strategies of real estate developers at the expense of understanding how investors are shaped by regulatory environments. In contrast, using the case of institutional investment in London’s private rental housing (Build to Rent), in this article I argue that unpacking the private sector and the development process helps reveal different types of risk which necessitate variegated responses from within the real estate sector. In doing so, I demonstrate the complexities of the private sector in urban development, especially housing provision, and the limitations of a binary conceptualised around pro- and anti-development narratives when discussing planning decisions. Instead, I show the multiplicity of responses from within the private sector, and how these reflect particular approaches to risk management. Uncovering this helps theorise the complexities of governing housing systems and demonstrates the potential for risk-based urban governance analysis in the future.

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Breast Cancer with Bone Metastasis: Molecular Insights and Clinical Management

Cells ◽

10.3390/cells10061377 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1377

Author(s):

Konstantinos Venetis ◽

Roberto Piciotti ◽

Elham Sajjadi ◽

Marco Invernizzi ◽

Stefania Morganti ◽

...

Keyword(s):

Breast Cancer ◽

Bone Metastasis ◽

Clinical Management ◽

Bone Destruction ◽

Metastatic Breast ◽

Breast Cancer Patients ◽

Incurable Condition ◽

Skeletal Related Events ◽

Relevant Topic ◽

Systemic Therapies

Despite the remarkable advances in the diagnosis and treatment of breast cancer patients, the presence or development of metastasis remains an incurable condition. Bone is one of the most frequent sites of distant dissemination and negatively impacts on patient’s survival and overall frailty. The interplay between tumor cells and the bone microenvironment induces bone destruction and tumor progression. To date, the clinical management of bone metastatic breast cancer encompasses anti-tumor systemic therapies along with bone-targeting agents, aimed at slowing bone resorption to reduce the risk of skeletal-related events. However, their effect on patients’ survival remains controversial. Unraveling the biology that governs the interplay between breast neoplastic cells and bone tissue would provide means for the development of new therapeutic agents. This article outlines the state-of-the art in the characterization and targeting the bone metastasis in breast cancer, focusing on the major clinical and translational studies on this clinically relevant topic.

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