scholarly journals Psychological Impact and Associated Factors After Disclosure of Genetic Test Results Concerning Hereditary Nonpolyposis Colorectal Cancer

10.5772/28873 ◽  
2012 ◽  
Author(s):  
Hitoshi Okamura
Keyword(s):  
Colorectal Cancer ◽  
Associated Factors ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Genetic Test ◽  
Psychological Impact ◽  
Test Results ◽  
Genetic Test Results ◽  
Hereditary Nonpolyposis

scholarly journals Interpretation of Genetic Test Results for Hereditary Nonpolyposis Colorectal Cancer

JAMA ◽  
1999 ◽  
Vol 282 (3) ◽  
pp. 247 ◽  
Author(s):  
Sapna Syngal ◽  
Edward A. Fox ◽  
Christine Li ◽  
Marisa Dovidio ◽  
Charis Eng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Genetic Test ◽  
Test Results ◽  
Genetic Test Results ◽  
Hereditary Nonpolyposis

Psychological impact and associated factors after disclosure of genetic test results concerning hereditary non-polyposis colorectal cancer

2008 ◽  
Vol 24 (5) ◽  
pp. 407-412
Author(s):  
Manami Yamashita ◽  
Hitoshi Okamura ◽  
Yoshie Murakami ◽  
Kokichi Sugano ◽  
Teruhiko Yoshida ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Associated Factors ◽  
Genetic Test ◽  
Psychological Impact ◽  
Test Results ◽  
Genetic Test Results

scholarly journals A Dynamic Family History model Of Hereditary Nonpolyposis Colorectal Cancer and Critical Illness Insurance

2007 ◽  
Vol 2 (2) ◽  
pp. 289-325 ◽  
Author(s):  
L. Lu ◽  
A. S. Macdonald ◽  
H. R. Waters ◽  
F. Yu
Keyword(s):  
Colorectal Cancer ◽  
Critical Illness ◽  
Family History ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Familial Aggregation ◽  
Family History Information ◽  
Dna Mismatch ◽  
Genetic Test Results ◽  
Hereditary Nonpolyposis ◽  
History Of

ABSTRACTHereditary nonpolyposis colorectal cancer (HNPCC) is characterised by the familial aggregation of cancer of the colon and rectum (CRC). It may be caused by any of five mutations in DNA mismatch repair (MMR) genes or by non-genetic factors, such as life style. However, it accounts for only about 2% of CRC, which is a very common cancer. Previous actuarial models, of diseases with only genetic causes, assumed that a family history of the disease shows mutations to be present, but this is not true of HNPCC. This is a significant limitation, since the best information available to an underwriter (especially if the use of genetic test results is banned) is likely to be knowledge of a family history of CRC. We present a Markov model of CRC and HNPCC, which includes the presence of a family history of CRC as a state, and estimate its intensities allowing for MMR genotype. Using this we find the MMR mutation probabilities for an insurance applicant with a family history of CRC. Our model greatly simplifies the intensive computational burden of finding such probabilities by integrating over complex models of hidden family structure. We estimate the costs of critical illness insurance given the applicant's genotype or the presence of a family history. We then consider what the cost of adverse selection might be, if insurers are unable to use genetic tests or family history information. We also consider the effect of using alternative definitions of a family history in underwriting.

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

2000 ◽  
Vol 94 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Claire Julian-Reynier ◽  
Fran�ois Eisinger ◽  
Fran�oise Chabal ◽  
Christine Lasset ◽  
Catherine Nogu�s ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Associated Factors ◽  
Genetic Test ◽  
Test Results ◽  
Cancer Genetic ◽  
Genetic Test Results ◽  
The Family

Genetic counselling: Psychological impact and concerns

2018 ◽  
Author(s):  
Bryan J. Traynor ◽  
Adriano Chiò
Keyword(s):  
Genetic Counselling ◽  
Clinical Medicine ◽  
Genetic Test ◽  
Clinical Care ◽  
Psychological Impact ◽  
Test Results ◽  
Sequencing Technology ◽  
Genetic Test Results ◽  
Lateral Sclerosis

Genetic counselling is the process by which the patients or relatives at risk of an inherited disorder are advised of the consequences and nature of the disorder, the probability of developing or transmitting it, and the options open to them in clinical management of their disease and family planning. Genetic counselling centres on helping patients understand the implications of their genetic test results. Advances in sequencing technology are changing the scope and practice of genetic counselling. It is likely that the role of genomics in clinical medicine will continue to grow over the next decade, and may eventually dominate the practice of health care. Genetic counselling is an increasingly important aspect in the clinical care of patients diagnosed with amyotrophic lateral sclerosis due to rapid advances in our understanding of the underlying genetics of this disorder.

scholarly journals Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma

Cancer ◽  
2004 ◽  
Vol 101 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Yoshie Murakami ◽  
Hitoshi Okamura ◽  
Kokichi Sugano ◽  
Teruhiko Yoshida ◽  
Keiko Kazuma ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Genetic Test ◽  
Test Results ◽  
Genetic Test Results ◽  
Hereditary Nonpolyposis ◽  
Psychologic Distress ◽  
Hereditary Nonpolyposis Colorectal Carcinoma
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