Psychological impact and associated factors after disclosure of genetic test results concerning hereditary non-polyposis colorectal cancer

2008 ◽  
Vol 24 (5) ◽  
pp. 407-412
Author(s):  
Manami Yamashita ◽  
Hitoshi Okamura ◽  
Yoshie Murakami ◽  
Kokichi Sugano ◽  
Teruhiko Yoshida ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Associated Factors ◽  
Genetic Test ◽  
Psychological Impact ◽  
Test Results ◽  
Genetic Test Results

scholarly journals Interpretation of Genetic Test Results for Hereditary Nonpolyposis Colorectal Cancer

JAMA ◽  
1999 ◽  
Vol 282 (3) ◽  
pp. 247 ◽  
Author(s):  
Sapna Syngal ◽  
Edward A. Fox ◽  
Christine Li ◽  
Marisa Dovidio ◽  
Charis Eng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Genetic Test ◽  
Test Results ◽  
Genetic Test Results ◽  
Hereditary Nonpolyposis

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

2000 ◽  
Vol 94 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Claire Julian-Reynier ◽  
Fran�ois Eisinger ◽  
Fran�oise Chabal ◽  
Christine Lasset ◽  
Catherine Nogu�s ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Associated Factors ◽  
Genetic Test ◽  
Test Results ◽  
Cancer Genetic ◽  
Genetic Test Results ◽  
The Family

Genetic counselling: Psychological impact and concerns

2018 ◽  
Author(s):  
Bryan J. Traynor ◽  
Adriano Chiò
Keyword(s):  
Genetic Counselling ◽  
Clinical Medicine ◽  
Genetic Test ◽  
Clinical Care ◽  
Psychological Impact ◽  
Test Results ◽  
Sequencing Technology ◽  
Genetic Test Results ◽  
Lateral Sclerosis

Genetic counselling is the process by which the patients or relatives at risk of an inherited disorder are advised of the consequences and nature of the disorder, the probability of developing or transmitting it, and the options open to them in clinical management of their disease and family planning. Genetic counselling centres on helping patients understand the implications of their genetic test results. Advances in sequencing technology are changing the scope and practice of genetic counselling. It is likely that the role of genomics in clinical medicine will continue to grow over the next decade, and may eventually dominate the practice of health care. Genetic counselling is an increasingly important aspect in the clinical care of patients diagnosed with amyotrophic lateral sclerosis due to rapid advances in our understanding of the underlying genetics of this disorder.

scholarly journals Colorectal Cancer Risk Perception on the Basis of Genetic Test Results in Individuals at Risk for Lynch Syndrome

2009 ◽  
Vol 27 (24) ◽  
pp. 3981-3986 ◽  
Author(s):  
Shilpa Grover ◽  
Elena M. Stoffel ◽  
Rowena C. Mercado ◽  
Beth M. Ford ◽  
Wendy K. Kohlman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Testing ◽  
Risk Perception ◽  
Cancer Risk ◽  
Lynch Syndrome ◽  
Genetic Test ◽  
Genetic Test Result ◽  
Test Results ◽  
Genetic Test Results ◽  
Test Result

Purpose Lynch syndrome is associated with inherited germline mutations in mismatch repair (MMR) genes. Genetic testing in high-risk individuals may yield indeterminate results if no mutation is found or if a mutation of unclear pathogenic significance is observed. There are limited data regarding how well patients with Lynch syndrome understand the clinical implications of genetic test results. This study examines colorectal cancer (CRC) risk perception in individuals tested for MMR mutations and identifies the factors associated with an appropriate interpretation of their cancer risk. Patients and Methods A total of 159 individuals who met the Revised Bethesda Guidelines and had previously undergone genetic testing completed a questionnaire eliciting demographic data, cancer history, genetic test results, and an estimate of their CRC risk. Associations between clinical factors, genetic test results, and CRC risk perception were explored using multivariable analyses. Results Of the 100 individuals with a pathogenic mutation (true positive), 90 (90%) correctly estimated their CRC risk as “high” or “very high” compared with other individuals their age. However, only 23 (62%) of 37 individuals with an indeterminate genetic test result correctly estimated their risk. Individuals with a history of Lynch syndrome–associated cancer (odds ratio [OR], 0.1; 95% CI, 0.1 to 0.6) or indeterminate genetic test results (OR, 0.2; 95% CI, 0.1 to 0.6) were significantly less likely to estimate their CRC risk as increased. Conclusion Patients at risk for Lynch syndrome with an indeterminate genetic test result may be falsely reassured. It is important that health care providers continue to discuss the implications of uninformative results on lifetime cancer risk.

Parents' long-term adjustment to the genetic test results of minors at risk for Long QT Syndrome

2004 ◽  
Author(s):  
K. S. W. H. Hendriks ◽  
F. J. M. Grosfeld ◽  
A. A. M. Wilde ◽  
J. van den Bout ◽  
I. M. van Langen ◽  
...  
Keyword(s):  
At Risk ◽  
Long Qt Syndrome ◽  
Genetic Test ◽  
Test Results ◽  
Long Qt ◽  
Genetic Test Results ◽  
Qt Syndrome
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