scholarly journals Acid-Sensing Ion Channels in Neurodegenerative Diseases: Potential Therapeutic Target

10.5772/28825 ◽  
2011 ◽  
Author(s):  
Chu Xiang-Ping ◽  
Wang John ◽  
Xiong Zhi-Gang
Keyword(s):  
Ion Channels ◽  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Acid Sensing Ion Channels

scholarly journals DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases

2019 ◽  
Vol 27 (4) ◽  
pp. 345-364 ◽  
Author(s):  
Nidheesh Thadathil ◽  
Roderick Hori ◽  
Jianfeng Xiao ◽  
Mohammad Moshahid Khan
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Potential Therapeutic Target ◽  
Strand Breaks

scholarly journals Necroptosis in neurodegenerative diseases: a potential therapeutic target

2017 ◽  
Vol 8 (6) ◽  
pp. e2905-e2905 ◽  
Author(s):  
Shuo Zhang ◽  
Mi-bo Tang ◽  
Hai-yang Luo ◽  
Chang-he Shi ◽  
Yu-ming Xu
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation

2017 ◽  
Vol 2017 ◽  
pp. 1-18 ◽  
Author(s):  
Audrey Ortega-Ramírez ◽  
Rosario Vega ◽  
Enrique Soto
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Ion Channels ◽  
Neurodegenerative Diseases ◽  
Therapeutic Targets ◽  
Recent Advances ◽  
Acid Sensing Ion Channels ◽  
Inflammatory Processes

Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues. Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.

The Nrf2-ARE pathway: A potential therapeutic target for neurodegenerative diseases

2007 ◽  
Vol 1302 ◽  
pp. 143-153 ◽  
Author(s):  
Jeffrey A. Johnson ◽  
Delinda A. Johnson ◽  
Jong-Min Lee ◽  
Jiang Li ◽  
Andrew D. Kraft ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target
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