The Nrf2-ARE pathway: A potential therapeutic target for neurodegenerative diseases

2007 ◽  
Vol 1302 ◽  
pp. 143-153 ◽  
Author(s):  
Jeffrey A. Johnson ◽  
Delinda A. Johnson ◽  
Jong-Min Lee ◽  
Jiang Li ◽  
Andrew D. Kraft ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases

2019 ◽  
Vol 27 (4) ◽  
pp. 345-364 ◽  
Author(s):  
Nidheesh Thadathil ◽  
Roderick Hori ◽  
Jianfeng Xiao ◽  
Mohammad Moshahid Khan
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Potential Therapeutic Target ◽  
Strand Breaks

scholarly journals Necroptosis in neurodegenerative diseases: a potential therapeutic target

2017 ◽  
Vol 8 (6) ◽  
pp. e2905-e2905 ◽  
Author(s):  
Shuo Zhang ◽  
Mi-bo Tang ◽  
Hai-yang Luo ◽  
Chang-he Shi ◽  
Yu-ming Xu
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

2015 ◽  
Vol 9 ◽  
Author(s):  
Michal Mielcarek ◽  
Daniel Zielonka ◽  
Alisia Carnemolla ◽  
Jerzy T. Marcinkowski ◽  
Fabien Guidez
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals mTOR controls neurotoxic lysosome exocytosis in inflammatory reactive astrocytes

2021 ◽  
Author(s):  
Brendan Rooney ◽  
Kun Leng ◽  
Frank McCarthy ◽  
Indigo V. L. Rose ◽  
Kari A Herrington ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Reactive Astrocytes ◽  
Biological Mechanisms ◽  
Potential Therapeutic Target

Inflammatory reactive astrocytes lose homeostatic functions and can be neurotoxic, potentially contributing to neurodegenerative diseases. However, the underlying cell biological mechanisms are not fully understood. Here, we demonstrate that lysosomes are remodeled and alkalinized in inflammatory reactive astrocytes, and that lysosome exocytosis drives astrocyte-mediated neurotoxicity. CRISPRi screens uncover mTOR as a regulator of neurotoxic lysosome exocytosis. These results pinpoint lysosome remodeling and exocytosis in inflammatory reactive astrocytes as a potential therapeutic target.

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