scholarly journals Role of Nitric Oxide in Extracellular Matrix Metabolism and Inflammation in Diabetic Wound Healing

10.5772/28147 ◽  
2011 ◽  
Author(s):  
Victor L. ◽  
Audra D. ◽  
Brandon M. ◽  
Eric M. ◽  
Michael A. ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Matrix Metabolism

scholarly journals Therapeutic Role of Nitric Oxide in Diabetic Wound Healing: A Systematic Review

2021 ◽  
pp. 68-80
Author(s):  
Mayur Meghashyam Chavhan ◽  
Ranjit Vinayak Gadhave ◽  
Yogita Sachin Ozarde ◽  
Ganesh Bhaurao Choudhari
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Bacterial Infections ◽  
The Body ◽  
Low Level Laser Therapy ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Post injury, healing of wound is essential for recovery of uprightness of the body, which is one of the complex, continuous and unanticipated chains of events in case of diabetic patients. Nitric oxide represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Impaired wound healing is a prominent diabetic complication which may lead to amputations also. In addition to modern medicines we can use nitric oxide therapy prominently for diabetic wound healing. Prominent and proven role of nitric oxide as well as conventional materials (like metformin and hydrogen sulphide, whey proteins, acidified nitrile etc), therapies (like low level laser therapy, hyperbaric oxygen therapy etc) and techniques (like in vivo implants with biosensors) can be taken into consideration. Many plant extracts showed promising results for wound healing activity by increasing nitric oxide levels. Use of modern technologies such as implant with biosensor and technique like sonic head hog gene are available for diabetic wound healing using Nitric oxide. In this review, an attempt has been made to compile comprehensive updated information of role of nitric oxide in diabetic wound healing, which may be exploited by focusing more on development of effective strategies to treat diabetes-associated wound.

scholarly journals Nitric Oxide Therapy for Diabetic Wound Healing

2019 ◽  
Vol 8 (12) ◽  
pp. 1801210 ◽  
Author(s):  
Maggie J. Malone‐Povolny ◽  
Sara E. Maloney ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Nitric Oxide Therapy

scholarly journals Abnormal Cell Responses and Role of TNF-αin Impaired Diabetic Wound Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fanxing Xu ◽  
Chenying Zhang ◽  
Dana T. Graves
Keyword(s):  
Wound Healing ◽  
Macrophage Polarization ◽  
Diabetic Wound ◽  
Major Health Problem ◽  
Abnormal Cell ◽  
Fibroblast Migration ◽  
Cell Responses ◽  
Impaired Healing ◽  
Diabetic Wound Healing

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-αalso contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.

A Mussel-Inspired Extracellular Matrix-Mimicking Composite Scaffold for Diabetic Wound Healing

2020 ◽  
Vol 3 (7) ◽  
pp. 4052-4061 ◽  
Author(s):  
Yuqi Jiang ◽  
You Li ◽  
Jiankai Li ◽  
Yiming Han ◽  
Pengju Zhang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Composite Scaffold ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals An Essential Role of NRF2 in Diabetic Wound Healing

Diabetes ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 780-793 ◽  
Author(s):  
Min Long ◽  
Montserrat Rojo de la Vega ◽  
Qing Wen ◽  
Manish Bharara ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Role ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration

2011 ◽  
Vol 9 (4) ◽  
pp. 355-361 ◽  
Author(s):  
R Madhyastha ◽  
H Madhyastha ◽  
Y Nakajima ◽  
S Omura ◽  
M Maruyama
Keyword(s):  
Wound Healing ◽  
Diabetic Wound ◽  
Fibroblast Migration ◽  
Diabetic Wound Healing
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