scholarly journals Investigation of the Oxidative Stress, the Altered Function of Platelets and Neutrophils, in thePatients with Peripheral Arterial Disease

10.5772/27779 ◽  
2012 ◽  
Author(s):  
Maria Kurthy ◽  
Gabor Jancso ◽  
Endre Arato ◽  
Laszlo Sinay ◽  
Janos Lantos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease

2006 ◽  
Vol 28 (5) ◽  
pp. 608-612 ◽  
Author(s):  
L. Loffredo ◽  
A. Marcoccia ◽  
P. Pignatelli ◽  
P. Andreozzi ◽  
M.C. Borgia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Vascular ◽  
2020 ◽  
pp. 170853812094724
Author(s):  
Ufuk Turan Kursat Korkmaz ◽  
Ahmet Yuksel ◽  
Ayhan Cetinkaya ◽  
Yusuf Velioglu ◽  
Erhan Renan Ucaroglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Peripheral Arterial Disease ◽  
Laboratory Data ◽  
Arterial Disease ◽  
Control Group ◽  
Study Group ◽  
Total Thiol ◽  
Peripheral Arterial ◽  
Study Participants

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case–control study. Participants’ baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group ( p = 0.045, p = 0.000 and p = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group ( p = 0.000, p = 0.000 and p = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

scholarly journals Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: Effect of an antioxidant treatment

2006 ◽  
Vol 44 (3) ◽  
pp. 525-530 ◽  
Author(s):  
Lorenzo Loffredo ◽  
Pasquale Pignatelli ◽  
Roberto Cangemi ◽  
Paola Andreozzi ◽  
Maria Antonietta Panico ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Antioxidant Treatment ◽  
Disease Effect ◽  
Peripheral Arterial ◽  
And Oxidative Stress

PO15-398 OXIDATIVE-STRESS MEDIATED ARTERIAL DYSFUNCTION IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE

2007 ◽  
Vol 8 (1) ◽  
pp. 115
Author(s):  
L. Loffredo ◽  
A. Marcoccia ◽  
P. Pignatelli ◽  
P. Andreozzi ◽  
L. Perri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

The Role of Combined Assessment of Defense Against Oxidative Stress and Inflammation in the Evaluation of Peripheral Arterial Disease

2011 ◽  
Vol 11 (6) ◽  
pp. 453-464 ◽  
Author(s):  
A. Rull ◽  
R. Garcia ◽  
L. Fernandez-Sender ◽  
R. Beltran-Debon ◽  
G. Aragones ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

Prognostic Values of Inflammation and Oxidative Stress Biomarkers on the Risk of Peripheral Arterial Disease in Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2220-PUB
Author(s):  
MATHILDE NATIVEL ◽  
FABRICE SCHNEIDER ◽  
PIERRE SAULNIER ◽  
OLIVIER MEILHAC ◽  
PHILIPPE RONDEAU ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Peripheral Arterial ◽  
And Oxidative Stress

scholarly journals Effects of drinking hydrogen-rich water in men at risk of peripheral arterial disease: a randomized placebo-controlled trial

2021 ◽  
Author(s):  
Qianqian Gu ◽  
Boyan Liu ◽  
Junli Xue ◽  
Min Zhao ◽  
Xiaoyi Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
At Risk ◽  
Placebo Group ◽  
Peripheral Arterial Disease ◽  
Cell Function ◽  
Pure Water ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Hdl Function ◽  
Peripheral Arterial

Abstract Aims Smoking, hypertension, hyperlipidemia, and diabetes are considered to increase the incidence of peripheral arterial disease (PAD). They can activate endogenous free radicals, cause inflammation and oxidative stress, and lead to endothelial cell dysfunction. Hydrogen (H2) has been proven to decrease oxidative stress, improve cell function, and reduce chronic inflammation. The purpose of this research was to validate the role of H2 in individuals who are at risk of PAD.Methods Sixty subjects were randomly assigned to placebo (PBO) group or H2-rich water (HRW) group and drank either bottled pure water or H2-rich water (245 mL/time, 3 times/d) for ten weeks.Results The pulse wave velocity was ameliorated in the HRW group with no significant change in the ankle-brachial index. The serum total cholesterol of the HRW group was significantly reduced compared to the placebo group. In addition, compared to baseline, the levels of lipoprotein(a) was decreased, the malondialdehyde content was reduced, the superoxide dismutase activity was increased, and the expression of intercellular cell adhesion molecule-1 was decreased significantly in the HRW group. The oxidized phospholipid of 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphatidylcholine level in the HRW group were significantly reduced compared to the placebo group. Finally, H2 significantly improved the antioxidant, antiinflammatory, and antiapoptotic abilities of high-density lipoprotein (HDL).Conclusions Drinking HRW can improve vascular sclerosis indicators, improve dyslipidemia, reduce vascular oxidative stress and inflammation, and improve HDL function. H2 may be used to prevent and relieve PAD caused by major risk factors such as smoking, hypertension, hyperlipidemia, and diabetes.

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