scholarly journals Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: Effect of an antioxidant treatment

2006 ◽  
Vol 44 (3) ◽  
pp. 525-530 ◽  
Author(s):  
Lorenzo Loffredo ◽  
Pasquale Pignatelli ◽  
Roberto Cangemi ◽  
Paola Andreozzi ◽  
Maria Antonietta Panico ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Antioxidant Treatment ◽  
Disease Effect ◽  
Peripheral Arterial ◽  
And Oxidative Stress

Prognostic Values of Inflammation and Oxidative Stress Biomarkers on the Risk of Peripheral Arterial Disease in Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2220-PUB
Author(s):  
MATHILDE NATIVEL ◽  
FABRICE SCHNEIDER ◽  
PIERRE SAULNIER ◽  
OLIVIER MEILHAC ◽  
PHILIPPE RONDEAU ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Peripheral Arterial ◽  
And Oxidative Stress

scholarly journals Pathophysiology of chronic peripheral ischemia: new perspectives

2020 ◽  
Vol 11 ◽  
pp. 204062231989446
Author(s):  
Salvatore Santo Signorelli ◽  
Luca Vanella ◽  
Nader G. Abraham ◽  
Salvatore Scuto ◽  
Elisa Marino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
New Drugs ◽  
Peripheral Arteries ◽  
Chronic Ischemia ◽  
Peripheral Ischemia ◽  
Oxidative Markers ◽  
Peripheral Arterial ◽  
And Oxidative Stress

Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.

scholarly journals Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease

2006 ◽  
Vol 28 (5) ◽  
pp. 608-612 ◽  
Author(s):  
L. Loffredo ◽  
A. Marcoccia ◽  
P. Pignatelli ◽  
P. Andreozzi ◽  
M.C. Borgia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Association of Carboxyhemoglobin Levels with Peripheral Arterial Disease in Chronic Smokers Managed at Dr George Mukhari Academic Hospital

2020 ◽  
Vol 17 (15) ◽  
pp. 5581
Author(s):  
Mashudu Nemukula ◽  
Motetelo Alfred Mogale ◽  
Honey Bridget Mkhondo ◽  
Lizette Bekker
Keyword(s):  
Nitric Oxide ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Academic Hospital ◽  
Convenience Sample ◽  
Logistic Analysis ◽  
Arterial Dilation ◽  
Peripheral Arterial ◽  
Arterial Damage ◽  
Multivariate Logistic Analysis

Chronic cigarette smokers (CCS) are known to have elevated levels of carboxyhemoglobin (COHb). However, it is not known whether increased levels of COHb are associated with endothelial dysfunction (ED), and therefore the development of peripheral arterial disease (PAD). The aim of the study was to investigate the association of blood COHb and plasma nitric oxide (NO) levels, and whether it is an independent risk factor in the development of PAD among CCS at Dr George Mukhari Academic Hospital (DGMAH). A sample of 120 CCS with PAD and a convenience sample of 100 CCS without PAD were recruited into the study. Blood COHb levels were measured using the ABL 90 FLEX CO-oximeter automated spectroscopy. Plasma nitric oxide (NO) levels were measure using ELISA. Logistic regression analysis was used to investigate the association of blood COHb and plasma NO with PAD. Blood COHb levels of CCS with PAD were significantly higher than those of CCS without PAD, and the NO levels of CCS with PAD were significantly lower than those of CCS without PAD. Although both the blood COHb and plasma NO in CCS were significantly associated with PAD in bivariate logistic analysis, only plasma NO was independently associated with PAD in multivariate logistic analysis. This finding is consistent with the hypothesis that COHb is a cause of arterial damage in PAD, leading to reduced NO, and therefore reduced arterial dilation.

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Vascular ◽  
2020 ◽  
pp. 170853812094724
Author(s):  
Ufuk Turan Kursat Korkmaz ◽  
Ahmet Yuksel ◽  
Ayhan Cetinkaya ◽  
Yusuf Velioglu ◽  
Erhan Renan Ucaroglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Peripheral Arterial Disease ◽  
Laboratory Data ◽  
Arterial Disease ◽  
Control Group ◽  
Study Group ◽  
Total Thiol ◽  
Peripheral Arterial ◽  
Study Participants

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case–control study. Participants’ baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group ( p = 0.045, p = 0.000 and p = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group ( p = 0.000, p = 0.000 and p = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

PO15-398 OXIDATIVE-STRESS MEDIATED ARTERIAL DYSFUNCTION IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE

2007 ◽  
Vol 8 (1) ◽  
pp. 115
Author(s):  
L. Loffredo ◽  
A. Marcoccia ◽  
P. Pignatelli ◽  
P. Andreozzi ◽  
L. Perri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial
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