scholarly journals Animal Models of Colitis: Lessons Learned, and Their Relevance to the Clinic

10.5772/27431 ◽  
2011 ◽  
Author(s):  
Matthew Barnett ◽  
Alan Fraser
Keyword(s):  
Animal Models ◽  
Lessons Learned

scholarly journals Monkey Models of Tuberculosis: Lessons Learned

2014 ◽  
Vol 83 (3) ◽  
pp. 852-862 ◽  
Author(s):  
Juliet C. Peña ◽  
Wen-Zhe Ho
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Animal Models ◽  
Nonhuman Primates ◽  
Lessons Learned ◽  
Preclinical Testing ◽  
Content Type ◽  
Cynomolgus Macaques ◽  
Drug Regimens

The use of animal models has been invaluable for studying the pathogenesis ofMycobacterium tuberculosisinfection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.

scholarly journals Breathing challenges in Rett Syndrome: Lessons learned from humans and animal models

2013 ◽  
Vol 189 (2) ◽  
pp. 280-287 ◽  
Author(s):  
Jan-Marino Ramirez ◽  
Christopher Scott Ward ◽  
Jeffrey Lorenz Neul
Keyword(s):  
Animal Models ◽  
Rett Syndrome ◽  
Lessons Learned

Neuroinflammation and Alzheimer’s disease: lessons learned from 5-lipoxygenase

2014 ◽  
Vol 5 (3) ◽  
Author(s):  
Yash Joshi ◽  
Domenico Praticò
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Amyloid Beta ◽  
Neuronal Cells ◽  
Lessons Learned ◽  
Brain Inflammation ◽  
Complex Relationship ◽  
Amyloid Hypothesis

AbstractAside from the well-known amyloid beta and tau pathologies found in Alzheimer’s disease (AD), neuroinflammation is a well-established aspect described in humans and animal models of the disease. Inflammatory perturbations are evident not only in neurons, but also in non-neuronal cells and cytokines in the AD brain. Although the amyloid hypothesis implicates amyloid beta (Aβ) as the prime initiator of the AD, brain inflammation in AD has a complex relationship between Aβ and tau. Using our work with the 5-lipoxygenase protein as an example, we suggest that at least in the case of AD, there is an interdependent and not necessarily hierarchical pathological relationship between Aβ, tau and inflammation.

T cell function in the aged: Lessons learned from animal models

2006 ◽  
Vol 6 (2) ◽  
pp. 73-97 ◽  
Author(s):  
Phyllis-Jean Linton ◽  
Joseph Lustgarten ◽  
Marilyn Thoman
Keyword(s):  
T Cell ◽  
Animal Models ◽  
Cell Function ◽  
Lessons Learned ◽  
T Cell Function
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