scholarly journals Steroid Hormones and Ovarian Cancer

10.5772/27123 ◽  
2011 ◽  
Author(s):  
Erin R. ◽  
Kwong-Kwok Wong
Keyword(s):  
Ovarian Cancer ◽  
Steroid Hormones

scholarly journals The Importance of Growth Factors and Steroid Hormones in Ovarian Cancer

Onkologie ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. 623-624 ◽  
Author(s):  
Simon P. Langdon ◽  
Dana Faratian ◽  
David J. Harrison
Keyword(s):  
Ovarian Cancer ◽  
Growth Factors ◽  
Steroid Hormones

scholarly journals Variation of Serum Interleukin, Gonadotropins hormone and Steroid hormone levels in women with Ovarian Cancer

2020 ◽  
Vol 11 (4) ◽  
pp. 7166-7174
Author(s):  
Lana Muhammad Ali ◽  
Parween Abdulsamad Ismail
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Steroid Hormones ◽  
Tumour Progression ◽  
Steroid Hormone ◽  
Follicle Stimulating Hormone ◽  
Delayed Diagnosis ◽  
Control Group ◽  
Hormone Levels ◽  
Pro Inflammatory Cytokines

Ovarian cancer has high mortality and delayed diagnosis. Inflammation is considered as a risk for ovarian carcinoma, and it contributes to all grades of tumour progression. Inflammation involved in the development of cancer cell and can be caused by an increase in the formation of pro-inflammatory cytokines. This research was conducted to assess serum Interleukin, Gonadotropins hormone and Steroid hormone levels in ovarian cancer patients and to assess their impact in disease action. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum gonadotropins(LH, luteinizing hormone; FSH, follicle-stimulating hormone), steroid hormones (estrogen, progesterone, prolactin, testosterone) and Interleukin (IL-4, IL-6, and IL-8). The results demonstrated significantly high values of steroid hormones (p<0.01, p<0.01, p<0.05,p<0.002, p<0.01 (estrogen, progesterone, prolactin, testosterone) and significantly high ( p<0.001, p<0.002, p<0.01)values in (IL-4, IL-6, and IL-8) in ovarian cancer in comparison with control group. There were also significantly high (p<0.0001, p<0.05 values of sera LH and FSH in women ovarian cancer in comparison with the control group. p<0.01, p<0.001) respectively in ovarian cancer in comparison with the control group. An elevation of serum steroid hormone, gonadotropins, and Interleukin levels in cases of ovarian carcinoma in our study is important as a marker of the disease.

Reproductive Steroid Hormones Alter Ovarian Cancer Progression in Mouse Models.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 343-343
Author(s):  
Kendra M. Hodgkinson ◽  
Laura Laviolette ◽  
Carolina Perez-Iratxeta ◽  
Barbara C. Vanderhyden
Keyword(s):  
Ovarian Cancer ◽  
Steroid Hormones ◽  
Mouse Models ◽  
Cancer Progression

Diagnostic significance of steroid hormones in patients with ovarian cancer

1986 ◽  
Vol 9 (4) ◽  
pp. 307-314 ◽  
Author(s):  
D. Mango ◽  
P. Scirpa ◽  
F. Battaglia ◽  
E. Tartaglia ◽  
P. Manna
Keyword(s):  
Ovarian Cancer ◽  
Steroid Hormones ◽  
Diagnostic Significance

Circulating Expressions of Gonadotropin Releasing Hormones and Risk of Ovarian Cancer

2021 ◽  
Vol 15 (11) ◽  
pp. 3372-3375
Author(s):  
Gulshan Parveen ◽  
Ali Hassan ◽  
Muhammad Hassam Rehm ◽  
Awais Altaf ◽  
Nureen Zahra ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Steroid Hormones ◽  
Cancer Progression ◽  
Healthy Individuals ◽  
Blood Samples ◽  
Elisa Kit ◽  
Signaling Mechanisms ◽  
Keywords Ovarian Cancer ◽  
Steroidal Hormones ◽  
Tumor Survival

Background: Ovarian cancer (OC) is a worst type of malignancy in the field of gynecology. This is because ovarian tumors diagnosed at advanced stage of disease. The exact mechanism for its development is still unknown. Aim: The aim of this study is to measure the levels of steroidal hormones and their function in ovarian cancer progression. Methods: In the present study, fifty ovarian cancer patients and fifty control individuals were taken and serum was separated from their blood samples. The levels of steroid hormones were measured by ELISA kit methods. Results: Result of the current study determined the levels of E2, progesterone, testosterone, FSH, LH, 17-β-HSD-I, 17-β-HSD-II, cortisol and aromatase were extensively higher in patient group in comparison with healthy individuals. Conclusion: Current study concluded the Study concluded that overexpression of steroid hormones may lead to enhance tumor survival in ovarian cancer through various signaling mechanisms. Keywords: Ovarian cancer, Estradiol, FSH, LH, progesterone

scholarly journals Tumor Repressor Protein 53 and Steroid Hormones Provide a New Paradigm for Ovarian Cancer Metastases

2014 ◽  
Vol 28 (1) ◽  
pp. 127-137 ◽  
Author(s):  
Lisa K. Mullany ◽  
Zhilin Liu ◽  
Kwong-Kwok Wong ◽  
Victoria Deneke ◽  
Yi Athena Ren ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Steroid Hormones ◽  
New Paradigm ◽  
Repressor Protein ◽  
Cancer Metastases

scholarly journals 17β-Estradiol Accelerates Tumor Onset and Decreases Survival in a Transgenic Mouse Model of Ovarian Cancer

Endocrinology ◽  
2010 ◽  
Vol 151 (3) ◽  
pp. 929-938 ◽  
Author(s):  
Laura A. Laviolette ◽  
Kenneth Garson ◽  
Elizabeth A. Macdonald ◽  
Mary K. Senterman ◽  
Kerri Courville ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Hormone Replacement Therapy ◽  
Mouse Model ◽  
Replacement Therapy ◽  
Steroid Hormones ◽  
Transgenic Mouse ◽  
Hormone Replacement ◽  
Transgenic Mouse Model ◽  
Tumor Dissemination ◽  
17Β Estradiol

Epithelial ovarian cancer is thought to be derived from the ovarian surface epithelium (OSE) but often goes undetected in the early stages, and as a result, the factors that contribute to its initiation and progression remain poorly understood. Epidemiological studies have suggested that the female steroid hormones are involved in ovarian carcinogenesis and that women who use hormone replacement therapy are at increased risk of developing the disease. A novel transgenic mouse model of ovarian cancer (tgCAG-LS-TAg) was developed to examine the role of the female reproductive steroid hormones [17β-estradiol (E2) and progesterone (P4)] on the initiation, progression, and pathology of ovarian cancer. The mouse model uses the Cre-LoxP system to induce expression of the simian virus 40 large and small T antigens (SV40 TAg). After targeted induction of the oncogene in the OSE, mice develop poorly differentiated ovarian tumors, tumor dissemination to tissues within the abdominal cavity, and a subset develops hemorrhagic ascites. Treatment with P4 had no impact on the disease, but E2 altered the pathophysiology, resulting in an earlier onset of tumors, decreased overall survival time, and a distinctive papillary histology. Normal ovaries collected from mice treated with E2, but lacking expression of SV40 TAg, displayed an increase in the areas of columnar and hyperplastic OSE cells compared to placebo-treated controls. A better understanding of the mechanisms by which E2 alters the morphology of normal OSE cells and reduces survival in this mouse model may translate into improved prevention and treatment options for women using hormone replacement therapy.

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