Ovarian cancer has high mortality and delayed diagnosis. Inflammation is considered as a risk for ovarian carcinoma, and it contributes to all grades of tumour progression. Inflammation involved in the development of cancer cell and can be caused by an increase in the formation of pro-inflammatory cytokines. This research was conducted to assess serum Interleukin, Gonadotropins hormone and Steroid hormone levels in ovarian cancer patients and to assess their impact in disease action. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum gonadotropins(LH, luteinizing hormone; FSH, follicle-stimulating hormone), steroid hormones (estrogen, progesterone, prolactin, testosterone) and Interleukin (IL-4, IL-6, and IL-8). The results demonstrated significantly high values of steroid hormones (p<0.01, p<0.01, p<0.05,p<0.002, p<0.01 (estrogen, progesterone, prolactin, testosterone) and significantly high ( p<0.001, p<0.002, p<0.01)values in (IL-4, IL-6, and IL-8) in ovarian cancer in comparison with control group. There were also significantly high (p<0.0001, p<0.05 values of sera LH and FSH in women ovarian cancer in comparison with the control group. p<0.01, p<0.001) respectively in ovarian cancer in comparison with the control group. An elevation of serum steroid hormone, gonadotropins, and Interleukin levels in cases of ovarian carcinoma in our study is important as a marker of the disease.
The Importance of Growth Factors and Steroid Hormones in Ovarian Cancer