scholarly journals Improvement of Atopic Dermatitis by Human Sebaceous Fatty Acids and Related Lipids

10.5772/26861 ◽  
2012 ◽  
Author(s):  
Hiroyuki Araki ◽  
Yoshiya Sugai ◽  
Hirofumi Takigaw
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis

scholarly journals Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Weng Sheng Kong ◽  
Naohiro Tsuyama ◽  
Hiroko Inoue ◽  
Yun Guo ◽  
Sho Mokuda ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Breast Milk ◽  
Saturated Fatty Acids ◽  
Lymphoid Cells ◽  
Interleukin 17 ◽  
Immune System Development ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns ◽  
Long Chain

AbstractBreastfeeding influences the immune system development in infants and may even affect various immunological responses later in life. Breast milk provides a rich source of early nutrition for infant growth and development. However, the presence of certain compounds in breast milk, related to an unhealthy lifestyle or the diet of lactating mothers, may negatively impact infants. Based on a cohort study of atopic dermatitis (AD), we find the presence of damage-associated molecular patterns (DAMPs) activity in the mother’s milk. By non-targeted metabolomic analysis, we identify the long-chain saturated fatty acids (LCSFA) as a biomarker DAMPs (+) breast milk samples. Similarly, a mouse model in which breastfed offspring are fed milk high in LCSFA show AD onset later in life. We prove that LCSFA are a type of damage-associated molecular patterns, which initiate a series of inflammatory events in the gut involving type 3 innate lymphoid cells (ILC3s). A remarkable increase in inflammatory ILC3s is observed in the gut, and the migration of these ILC3s to the skin may be potential triggers of AD. Gene expression analysis of ILC3s isolated from the gut reveal upregulation of genes that increase ILC3s and chemokines/chemokine receptors, which may play a role in ILC migration to the skin. Even in the absence of adaptive immunity, Rag1 knockout mice fed a high-LCSFA milk diet develop eczema, accompanied by increased gut ILC3s. We also present that gut microbiota of AD-prone PA milk-fed mice is different from non-AD OA/ND milk-fed mice. Here, we propose that early exposure to LCSFAs in infants may affect the balance of intestinal innate immunity, inducing a highly inflammatory environment with the proliferation of ILC3s and production of interleukin-17 and interleukin-22, these factors may be potential triggers or worsening factors of AD.

Comparative Analysis of Fecal Short Chain Fatty Acids Profiles in Atopic Dermatitis And Healthy Infants

2018 ◽  
Vol 141 (2) ◽  
pp. AB131 ◽  
Author(s):  
Le Duc Huy Ta ◽  
James Chun Yip Chan ◽  
Chiung-Hui Huang ◽  
Gaik Chin Yap ◽  
Lynette Pei-Chi Shek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Comparative Analysis ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Healthy Infants ◽  
Chain Fatty Acids

Supplementary therapy in canine atopic dermatitis

2019 ◽  
Vol 24 (8) ◽  
pp. 400-407
Author(s):  
Sue Paterson
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Specific Immunotherapy ◽  
Essential Fatty Acids ◽  
Topical Therapy ◽  
Allergen Specific Immunotherapy ◽  
Canine Atopic Dermatitis ◽  
Adequate Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Therapy for canine atopic dermatitis can be described as foundation or supplementary. Foundation therapy, which refers to allergen-specific immunotherapy, ciclosporin, glucocorticoids, lokivetmab and oclacitinib, is needed in all but the mildest of cases of canine atopic dermatitis. Supplementary therapies include drugs such as antihistamines, essential fatty acids, topical therapy and other systemic anti-inflammatory drugs. While it is uncommon for any of these supplementary drugs to provide adequate control of many cases of canine atopic dermatitis, they can reduce the frequency of relapse and reduce the amount of foundation therapy that is required when used in combination with them.

Effect of omega-3 fatty acids on canine atopic dermatitis

2004 ◽  
Vol 45 (6) ◽  
pp. 293-297 ◽  
Author(s):  
R. S. Mueller ◽  
K. V. Fieseler ◽  
M. J. Fettman ◽  
S. Zabel ◽  
R. A. W. Rosychuk ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Canine Atopic Dermatitis

PRENATAL ENVIRONMENTAL EXPOSURE, SUPPLEMENTATION WITH OMEGA-3 FATTY ACIDS DURING PREGNANCY AND RISK OF ATOPIC DERMATITIS IN MEXICAN INFANTS

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Albino Barraza-Villarreal ◽  
Consuelo Escamilla-Nuñez ◽  
Leticia Hernandez-Cadena ◽  
Peter Sly ◽  
Juan A. Rivera ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Environmental Exposure ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice

2013 ◽  
Vol 22 (4) ◽  
pp. 272-277 ◽  
Author(s):  
Masanori Fujii ◽  
Hiroyuki Nakashima ◽  
Junko Tomozawa ◽  
Yuki Shimazaki ◽  
Chie Ohyanagi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Polyunsaturated Fatty Acids ◽  
Skin Inflammation ◽  
Hairless Mice ◽  
Special Diet ◽  
Pruritic Skin

scholarly journals Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History

2010 ◽  
Vol 3 (4) ◽  
pp. 407-417
Author(s):  
Tereshchenko Sergey Yu.; ◽  
◽  
Prahin Efim I. ◽  
Novitzkiy Ivan A. ◽  
Tzhai Vitaly B. ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Atopic Dermatitis ◽  
Polyunsaturated Fatty Acids ◽  
Cord Blood ◽  
Total Ige
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