scholarly journals Proteases and Cartilage Degradation in Osteoarthritis

10.5772/26687 ◽  
2012 ◽  
Author(s):  
Judith Farley ◽  
Valeria C. ◽  
John S.
Keyword(s):  
Cartilage Degradation ◽  
And Cartilage

scholarly journals Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yan Zhou ◽  
Jianghua Ming ◽  
Yaming Li ◽  
Bochun Li ◽  
Ming Deng ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Apoptotic Cell ◽  
Synovial Fibroblasts ◽  
Cartilage Degeneration ◽  
Cartilage Degradation ◽  
Exosomal Mirnas ◽  
Exosomal Mirna ◽  
And Control ◽  
And Cartilage

AbstractMicroRNAs (miRNAs) encapsulated within exosomes can serve as essential regulators of intercellular communication and represent promising biomarkers of several aging-associated disorders. However, the relationship between exosomal miRNAs and osteoarthritis (OA)-related chondrocytes and synovial fibroblasts (SFCs) remain to be clarified. Herein, we profiled synovial fluid-derived exosomal miRNAs and explored the effects of exosomal miRNAs derived from SFCs on chondrocyte inflammation, proliferation, and survival, and further assessed their impact on cartilage degeneration in a surgically-induced rat OA model. We identified 19 miRNAs within synovial fluid-derived exosomes that were differentially expressed when comparing OA and control patients. We then employed a microarray-based approach to confirm that exosomal miRNA-126-3p expression was significantly reduced in OA patient-derived synovial fluid exosomes. At a functional level, miRNA-126-3p mimic treatment was sufficient to promote rat chondrocyte migration and proliferation while also suppressing apoptosis and IL-1β, IL-6, and TNF-α expression. SFC-miRNA-126-3p-Exos were able to suppress apoptotic cell death and associated inflammation in chondrocytes. Our in vivo results revealed that rat SFC-derived exosomal miRNA-126-3p was sufficient to suppress the formation of osteophytes, prevent cartilage degeneration, and exert anti-apoptotic and anti-inflammatory effects on articular cartilage. Overall, our findings indicate that SFC exosome‐delivered miRNA-126-3p can constrain chondrocyte inflammation and cartilage degeneration. As such, SFC-miRNA-126-3p-Exos may be of therapeutic value for the treatment of patients suffering from OA.

scholarly journals The Effect of a Lower Body Positive Pressure Supported Treadmill Exercise Regime on Systemic Biomarkers of Inflammation and Cartilage Degradation in Individuals with Knee Osteoarthritis: A Pilot Study

2021 ◽  
Vol 9 (3) ◽  
pp. 18
Author(s):  
Stephen Cornish ◽  
Jason Peeler
Keyword(s):  
Articular Cartilage ◽  
Knee Pain ◽  
Weight Bearing ◽  
Cartilage Degradation ◽  
Treadmill Walking ◽  
Positive Pressure ◽  
Control Group ◽  
Knee Oa ◽  
And Cartilage

Background: Knee osteoarthritis (OA) has been linked to a chronic low-grade inflammatory response and altered metabolic activity of articular cartilage. Objective: The purpose of this investigation was to evaluate the effectiveness of a 12-week (3 times/week) lower body positive pressure (LBPP) treadmill walking regime on knee pain and systemic biomarkers of inflammation and cartilage degradation. Methods: Sixteen overweight (BMI > 25 kg/m2) knee OA patients were randomized to a LBPP treadmill walking exercise group (N = 7) or non-exercise control group (N = 9). Baseline and 12-week follow-up assessments evaluated the following dependent variables: acute knee pain during full weight bearing treadmill walking; inflammatory biomarkers (C-reactive protein, interleukin-1β, interleukin-6, s100A8/A9, and tumor necrosis factor-α), and catabolic metabolism of articular cartilage (sCOMP). Results: Knee pain at baseline and follow-up remained unchanged for the non-exercise control group (P > 0.05). However, knee pain for the LBPP exercise group was significantly decreased at follow-up (P ≤ 0.05). No differences in the biomarkers of inflammation and cartilage degradation were observed for between and within group comparisons (all P > 0.05). Conclusions: Data suggested that the LBPP supported walking regime could be effectively used to promote regular weight bearing exercise without exacerbation of knee joint pain and did not increase levels of systemic inflammation or catabolic activity of articular cartilage in overweight knee OA patients. This pilot investigation offers important insight regarding the potential role that the LBPP technology could play in facilitating investigations examining the disease modifying effect of exercise on knee OA pathogenesis.

EFFECT OF EARLY FULL WEIGHT-BEARING AFTER JOINT INJURY ON INFLAMMATION AND CARTILAGE DEGRADATION

2006 ◽  
Vol 88 (10) ◽  
pp. 2201-2209 ◽  
Author(s):  
D. M. GREEN ◽  
P. C. NOBLE ◽  
J. R. BOCELL ◽  
J. S. AHUERO ◽  
B. A. POTEET ◽  
...  
Keyword(s):  
Weight Bearing ◽  
Cartilage Degradation ◽  
Full Weight Bearing ◽  
Joint Injury ◽  
And Cartilage

Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis

2018 ◽  
Vol 203 ◽  
pp. 6-14 ◽  
Author(s):  
Seung Hoon Lee ◽  
Ji Ye Kwon ◽  
JooYeon Jhun ◽  
KyungAh Jung ◽  
Sung-Hwan Park ◽  
...  
Keyword(s):  
Lactobacillus Acidophilus ◽  
Cartilage Degradation ◽  
Experimental Osteoarthritis ◽  
And Cartilage

scholarly journals AB0099 COCULTURE OF SYNOVIAL MEMBRANE AND CARTILAGE: A POTENTIAL HUMAN EX VIVO CARTILAGE DEGRADATION MODEL

2019 ◽  
Author(s):  
Johanna Mucke ◽  
Victoria Warzynski ◽  
Ellen Bleck ◽  
Thomas Pauly ◽  
Tim Claßen ◽  
...  
Keyword(s):  
Synovial Membrane ◽  
Ex Vivo ◽  
Cartilage Degradation ◽  
Degradation Model ◽  
And Cartilage
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