scholarly journals Naturally Occurring Antifungal Agents and Their Modes of Action

10.5772/26553 ◽  
2012 ◽  
Author(s):  
Isao Kubo ◽  
Kuniyoshi Shimizu ◽  
Ken-ichi Fujit
Keyword(s):  
Antifungal Agents ◽  
Modes Of Action ◽  
Naturally Occurring

New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole

2011 ◽  
Vol 46 (9) ◽  
pp. 4117-4124 ◽  
Author(s):  
Hasnae Bendaha ◽  
Lisa Yu ◽  
Rachid Touzani ◽  
Rachid Souane ◽  
Guri Giaever ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Tridentate Ligands ◽  
Modes Of Action ◽  
Biological Studies

Interactions between naturally occurring antifungal agents

2013 ◽  
Vol 64 (4) ◽  
pp. 510-512 ◽  
Author(s):  
Viktória Tóth ◽  
Melinda Szilágyi ◽  
Fruzsina Anton ◽  
Éva Leiter ◽  
I. Pócsi ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Naturally Occurring

A Comprehensive Review: Bio-Potential of Barbituric Acid and its Analogues

2020 ◽  
Vol 24 (2) ◽  
pp. 129-161
Author(s):  
Nusrat Shafiq ◽  
Uzma Arshad ◽  
Gul Zarren ◽  
Shagufta Parveen ◽  
Irum Javed ◽  
...  
Keyword(s):  
Barbituric Acid ◽  
Antifungal Agents ◽  
Single Point ◽  
Building Blocks ◽  
Specific Aspect ◽  
Medicinal Uses ◽  
Naturally Occurring ◽  
Wide Range ◽  
History Of ◽  
Bioactive Agents

In our present work, we emphasized on the potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring, barbituric acid (1) is inactive but in the derivative form, it has a large number of medicinal uses and nowadays, it has a great demand in the pharmaceutical industry. Barbituric acid has a wide range of applications in the synthesis of a diverse class of compounds like heterocyclic, carbocyclic, synthetic alkaloids, and due to its broad-spectrum applications, barbituric acid acquired the position of building blocks in synthetic chemistry. Through the history of humanity, a number of bioactive agents have been applied to cure the disease related to hypnotics and sedatives, while the exact efficacy of these agents was found to be limited. Till now, review articles on barbituric acid only express their specific aspect but in present review article, all aspects are discussed in detail to provide a platform to readers and researchers so that they could obtain all information and background knowledge from a single point.

An Overview on Pyranocoumarins: Synthesis and Biological Activities

2020 ◽  
Vol 23 (24) ◽  
pp. 2679-2721 ◽  
Author(s):  
Evangelia-Eirini N. Vlachou ◽  
Konstantinos E. Litinas
Keyword(s):  
Organic Compounds ◽  
Antifungal Agents ◽  
Biological Activities ◽  
Biological Properties ◽  
Pyran Ring ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Antibacterial And Antifungal ◽  
Anti Hiv

Pyrano- and dipyranocoumarins are classes of naturally occurring organic compounds with very interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyranocoumarins and dipyranocoumarins and the biological properties of those compounds. The synthesis involves the formation of the pyran ring, at first, from a coumarin or the formation of pyranone moiety from an existing pyran. Pyranocoumarins and dipyranocoumarins present anti-HIV, anti-cancer, neuroprotective, antidiabetic, antibacterial, antifungal, anti-inflammatory activities. Especially khellactones and calanolides are usually potent and selective in anti-HIV activity. Decursin and decursinol derivatives are effective as anticancer, neuroprotective, antidiabetic, antibacterial, and antifungal agents.

scholarly journals Modifications of PARP Medium Using Fluazinam, Miconazole, and Nystatin for Detection of Pythium spp. in Soil

Plant Disease ◽  
2007 ◽  
Vol 91 (12) ◽  
pp. 1591-1599 ◽  
Author(s):  
Y. Morita ◽  
M. Tojo
Keyword(s):  
New Media ◽  
Fusarium Oxysporum ◽  
Mycelial Growth ◽  
Antifungal Agents ◽  
Selective Medium ◽  
Plating Technique ◽  
Naturally Occurring ◽  
Different Types ◽  
Soil Dilution ◽  
Better Than

The standard Pythium selective medium PARP (pimaricin + ampicillin + rifampicin + pentachloronitrobenzene [PCNB] agar), was modified by replacing PCNB and pimaricin with other antifungal agents. Several antifungal agents such as fluazinam, miconazole, 2,4,5,6-tetrachloroisophthalonitrile (TPN), iminoctadine triacetate, tolclofos-methyl, captan, and nystatin, initially were screened for effects on Pythium growth. Based on these results, the following three media were developed: PARF (pimaricin + ampicillin + rifampicin + fluazinam agar), NARF (nystatin + ampicillin + rifampicin + fluazinam agar), and NARM (nystatin + ampicillin + rifampicin + miconazole agar). New media were comparable with PARP on yield of naturally occurring Pythium spp. from two different types of soil using the soil-dilution plating technique. PARF and NARF were significantly better than PARP on inhibition of non-pythiaceous microbes on the soil-dilution plates, but were significantly lower than PARP on the rate of mycelial growth of six of eight isolates belonging to seven species of Pythium. NARM was equivalent to PARP on inhibition of non-pythiaceous microbes except for Fusarium oxysporum, and was significantly better than PARP on rate of mycelial growth of five of eight isolates of Pythium.

Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitive and multidrug-resistant cancer cell lines

Phytomedicine ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Victor Kuete ◽  
Louis P. Sandjo ◽  
Judith L. Nantchouang Ouete ◽  
Hugues Fouotsa ◽  
Benjamin Wiench ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Multidrug Resistant ◽  
Modes Of Action ◽  
Naturally Occurring
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